US5353792A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sensing device
Assignee: AVL Medical Instruments AG
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Filing: 1993-07-26
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Granted: 1994-10-11
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Expires: 2013-07-26
Abstract
Abstract In order to simultaneously determine the concentrations of different analytes in several places in a tissue by means of a thin, biocompatible tube or cannula which is inserted into the tissue, the tube is provided with several areas along its length which contain either identical or different optically excitable and readable, preferably luminescence-optical, indicating substances for measuring the local distribution of one parameter, such as O 2 concentration or O 2 partial pressure, or for simultaneous measurement of at least two different parameters, e.g., pO 2 , pCO 2 or pH.
Inventors
- 👤 Dietrich W. Lubbers
- 👤 Hellfried Karpf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:35
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14525; A61B5/14528; A61B5/1455; A61B5/1459; A61B5/68; A61B5/6846; A61B5/6847; A61B5/686
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
62 words
An optical sensing device comprising a thin biocompatible tube having a tube wall and a longitudinal axis, said tube being insertable into human or animal tissue, wherein said biocompatible tube operates as a single light guide and has several areas axially displaced which contain different optically excitable and readable indicating substances, and further comprising means for exciting and reading said indicating substances.
Claim 2
Dependent Claim
62 words
An optical sensing device comprising a thin biocompatible tube having a tube wall and a longitudinal axis, said tube being insertable into human or animal tissue, wherein said biocompatible tube operates as a single light guide and has several areas axially displaced which contain different optically excitable and readable indicating substances, and further comprising means for exciting and reading said indicating substances.
Claim 3
Dependent Claim
97 words
An optical sensing device comprising a thin biocompatible tube having a tube wall and a longitudinal axis, said tube being insertable into human or animal tissue, wherein said tube is provided with a liquid, gel-like or solid tube filling, wherein the refractive index of said tube wall is lower than the refractive index of said tube filling, so that said tube filling operates as a single light guide and wherein said tube has several areas axially displaced which contain different, optically excitable and readable indicating substances, and further comprising means for exciting and reading said indicating substances.
Claim 4
Dependent Claim
97 words
An optical sensing device comprising a thin biocompatible tube having a tube wall and a longitudinal axis, said tube being insertable into human or animal tissue, wherein said tube is provided with a liquid, gel-like or solid tube filling, wherein the refractive index of said tube wall is lower than the refractive index of said tube filling, so that said tube filling operates as a single light guide and wherein said tube has several areas axially displaced which contain different, optically excitable and readable indicating substances, and further comprising means for exciting and reading said indicating substances.
Claim 5
Dependent Claim
24 words
A sensing device according to claims 1 or 2, wherein said tissue parameter is the O 2 concentration or the O 2 partial pressure.
Claim 6
Dependent Claim
27 words
A sensing device according to claims 1 or 2, wherein said at least two tissue parameters belong to the pO 2 , PCO 2 , pH group.
Claim 7
Dependent Claim
17 words
A sensing device according to claims 1 or 2, wherein said biocompatible tube is a microdialysis tube.
Claim 8
Dependent Claim
16 words
A sensing device according to claims 1 or 2, wherein said indicating substances are luminescence-optical substances.
Claim 9
Dependent Claim
31 words
A sensing device according to claims 1 or 2, wherein said tube is surrounded by a hollow needle, which is removable after said tube is inserted into human or animal tissue.
Claim 10
Dependent Claim
38 words
A sensing device according to claims 1 or 2, wherein one end of said biocompatible tube located in said tissue is mirror-faced and the other end is used for feeding in excitation radiation and picking up measurement radiation.
Claim 11
Dependent Claim
50 words
A sensing device according to claims 1 or 2, wherein said biocompatible tube is threadable through said tissue having both ends of said tube projecting from a tissue surface, one end of said tube being available for feeding in excitation radiation and the other end for picking up measurement radiation.
Claim 12
Dependent Claim
39 words
A sensing device according to claims 1 or 2, wherein at least one free end of said tube is provided with an optode foil in contact with said tissue surface for measuring the surface concentration of a given species.
Claim 13
Dependent Claim
40 words
A sensing device according to claims 1 or 2 comprising a probe with at least one mirror face inclined towards said longitudinal axis of said tube by about 45°, wherein said probe is insertable into said tube in axial direction.
Claim 14
Dependent Claim
16 words
A sensing device according to claim 11, wherein each said mirror face is a dichroitic mirror.
Claim 15
Dependent Claim
20 words
A sensing device according to claims 1 or 2, wherein said biocompatible tube is transparent in at least one area.
Claim 16
Dependent Claim
32 words
A sensing device according to claims 1 or 2, comprising means for contact-free feeding in excitation radiation and pick-up measurement radiation to said biocompatible tube, wherein said means includes an evaluation unit.
Claim 17
Dependent Claim
24 words
A sensing device according to claims 1 or 2, comprising indicating substances with an excitation and emission wavelength of about 600 to 1200 nm.
Claim 18
Dependent Claim
28 words
A sensing device according to claims 1 or 2, wherein at least parts of said biocompatible tube are made of material accumulating a sample substance to be measured.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-10 | 1998-04-11 | 1998-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-10 | 2002-04-11 | 2002-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-10 | 2006-04-11 | 2006-10-11 | $7700.00 | Window Closed / Lapsed |