US5370860A
Expired / Lapsed
US
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Lipophilic contrast agents for diagnostic image analysis
Assignee: Research Corp Technologies Inc
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Filing: 1993-07-29
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Granted: 1994-12-06
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Expires: 2013-07-29
Abstract
Abstract The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.
Inventors
- 👤 Gabriel A. Elgavish
- 👤 Sung K. Kim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:32
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/0002; A61K49/04; A61K49/06; A61K49/08; A61K49/085; A61K49/10; A61K49/101; A61K49/103; A61K49/18; A61K49/1806; A61K49/1812; A61K49/22; A61K49/221; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
200 words
A method for diagnostic image analysis comprising administering to a host a contrast enhancing amount of a contrast enhancing agent which comprises a complexing acid or a salt thereof and at least one metal ion of an element with an atomic number 21 to 29, 42 to 44 or 57 to 83, wherein said acid has the formula ##STR17## wherein a is 0 to 5; b is 1 to 5; each of a and b can be the same or different; each R is hydrogen, lower alkyl, hydroxy, halo, lower alkyoxy, aryl, or lower aralkyl; at least one of R 1 , R 2 , R 3 , R 4 or X has the formula ##STR18## wherein R 5 is a saturated or unsaturated hydrocarbon chain having 6 to 30 carbon atoms; and the others of R 1 , R 2 , R 3 , R 4 , or X are hydrogen, hydroxyl, --COOR 6 , --CONR 7 R 8 or a chelating moiety wherein R 6 , R 7 , and R 8 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, lower carboxyalkylene, or a chelating moiety; and subjecting said host to diagnostic image analysis.
Claim 2
Independent Claim
200 words
A method for diagnostic image analysis comprising administering to a host a contrast enhancing amount of a contrast enhancing agent which comprises a complexing acid or a salt thereof and at least one metal ion of an element with an atomic number 21 to 29, 42 to 44 or 57 to 83, wherein said acid has the formula ##STR17## wherein a is 0 to 5; b is 1 to 5; each of a and b can be the same or different; each R is hydrogen, lower alkyl, hydroxy, halo, lower alkyoxy, aryl, or lower aralkyl; at least one of R 1 , R 2 , R 3 , R 4 or X has the formula ##STR18## wherein R 5 is a saturated or unsaturated hydrocarbon chain having 6 to 30 carbon atoms; and the others of R 1 , R 2 , R 3 , R 4 , or X are hydrogen, hydroxyl, --COOR 6 , --CONR 7 R 8 or a chelating moiety wherein R 6 , R 7 , and R 8 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, lower carboxyalkylene, or a chelating moiety; and subjecting said host to diagnostic image analysis.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said host is a mammal.
Claim 4
Dependent Claim
23 words
The method of claim 1, wherein R 5 is a hydrocarbon chain substituted with a lower alkyl, hydroxyl, lower alkoxy or halogen moiety.
Claim 5
Dependent Claim
19 words
The method of claim 1, wherein R 5 is a saturated alkyl chain having 6 to 30 carbon atoms.
Claim 6
Dependent Claim
15 words
The method of claim 4, wherein said alkyl chain has 8 to 24 carbon atoms.
Claim 7
Dependent Claim
11 words
The method of claim 1, wherein R 1 is ##STR19## .
Claim 8
Dependent Claim
28 words
The method of claim 6, wherein R is hydrogen, R 2 , R 3 , R 4 and X are COOR 6 , and R 6 is hydrogen.
Claim 9
Dependent Claim
10 words
The method of claim 1 wherein X is ##STR20## .
Claim 10
Dependent Claim
29 words
The method of claim 8 wherein R is hydrogen, R 1 , R 2 , R 3 and R 4 are COOR 6 , and R 6 is hydrogen.
Claim 11
Dependent Claim
33 words
The method of claim 6 wherein R is hydrogen, R 2 and R 4 are --CONR 7 R 8 , R 3 is hydroxyl, and R 7 and R 8 are lower carboxyalkylene.
Claim 12
Dependent Claim
9 words
The method of claim 10, wherein a is 0.
Claim 13
Dependent Claim
13 words
The method of claim 1 wherein R 1 and R 3 are ##STR21##
Claim 14
Dependent Claim
23 words
The method of claim 12 wherein R is hydrogen, R 2 and R 4 are COOR 6 , and R 6 is hydrogen.
Claim 15
Dependent Claim
9 words
The method of claim 13 wherein a is 0.
Claim 16
Dependent Claim
28 words
The method of claim 12 wherein R is hydrogen, R 2 and R 4 are --CONR 7 R 8 and R 7 and R 8 are lower carboxyalkylene.
Claim 17
Dependent Claim
9 words
The method of claim 15 wherein a is 0.
Claim 18
Dependent Claim
11 words
The method of claim 1 wherein said complexing acid is N-(2-myristoyloxyethyl)-N'-(2-hydroxyethyl)-N,N'-bis[N",N"-bis(carboxymethyl)acetamido]-1,2-ethanediamine.
Claim 19
Dependent Claim
11 words
The method of claim 1 wherein said complexing acid is N,N'-bis(2-myristoyloxyethyl)N,N'-bis[N",N"-bis(carboxymethyl)acetamido]-1,2-ethanediamine.
Claim 20
Dependent Claim
12 words
The method of claim 1 wherein said complexing acid is N-(3-myristoyloxypropyl)diethylenetriamine-N,N',N",N"-tetraacetic acid.
Claim 21
Dependent Claim
11 words
The method of claim 1 wherein said complexing acid is N-(3-myristoyloxypropyl)-N,N-bis[2-[N',N'-bis(carboxymethyl)nitrilo]ethyl]amine.
Claim 22
Dependent Claim
26 words
The method of claim 1 wherein said contrast enhancing amount is about 0.001 mole to about 5 mmole of said agent per kilogram of said host.
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| 3.5 Years (Year 4) | 1997-12-05 | 1998-06-06 | 1998-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-12-05 | 2002-06-06 | 2002-12-06 | $3760.00 | Window Closed / Lapsed |
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