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US5380904A
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Process for rendering a surface biocompatible, and articles containing the same
Assignee: Abbott Vascular Devices Ltd
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Filing: 1993-12-20
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Granted: 1995-01-10
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Expires: 2013-12-20
Abstract
Abstract A compound of formula: ##STR1## in which X 1 is a reactive group that can react to form a covalent bond with a reactive group on the surface of a material to be rendered biocompatible, X 2 is a group --O.sup.⊖ or a precursor of such a group, n is 2, 3 or 4, Y is a group --N.sup.⊕ R 3 A.sup.⊖ wherein each R, which may be the same or different, is a C 1 -C 4 alkyl group and A.sup.⊖ is an anion present when X 2 is an electrically neutral group or Y is ##STR2## wherein R 1 together with X 2 forms a direct bond between the nitrogen and the phosphorus atoms.
Inventors
- 👤 Dennis Chapman
- 👤 Aziz A. Durrani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 01:39
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6564; C07F9/6581; C07F9/6584; C07F9/65842; C07F9/65844; A; A61; A61L; A61L33/00; A61L33/0076; A61L33/0082; C07C; C07C43/00; C07C43/30; C07C43/315; C07F5/00; C07F5/003; C07F9/06; C07F9/08; C07F9/09; C07F9/091; Y; Y10; Y10S; Y10S128/00; Y10S128/912
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
109 words
A method for rendering a surface of a material biocompatible comprising the steps of (1) applying to said surface a compound of the formula ##STR25## wherein X 1 is a reactive group which forms a covalent bond with a reactive group on said surface of said material to be rendered biocompatible, each R, which may be the same or different, is C 1 -C 4 alkyl and n is 2, 3 or 4; and (2) reacting said compound and said reactive group on said surface under conditions such that the group X 1 forms a covalent linkage with said reactive group on said surface thereby rendering said surface biocompatible.
Claim 2
Independent Claim
109 words
A method for rendering a surface of a material biocompatible comprising the steps of (1) applying to said surface a compound of the formula ##STR25## wherein X 1 is a reactive group which forms a covalent bond with a reactive group on said surface of said material to be rendered biocompatible, each R, which may be the same or different, is C 1 -C 4 alkyl and n is 2, 3 or 4; and (2) reacting said compound and said reactive group on said surface under conditions such that the group X 1 forms a covalent linkage with said reactive group on said surface thereby rendering said surface biocompatible.
Claim 3
Dependent Claim
11 words
The method according to claim 1, wherein each R is methyl.
Claim 4
Dependent Claim
10 words
The method according to claim 1, wherein n is 2.
Claim 5
Dependent Claim
10 words
The method according to claim 2, wherein n is 2.
Claim 6
Dependent Claim
82 words
An article having a surface which is to be brought into contact with body fluids, cells, tissues or a human or animal body, wherein said surface has been rendered biocompatible by treatment with a compound of the formula ##STR26## wherein X 1 is a reactive group which forms a covalent bond with a reactive group on said surface, and wherein each R, which may be the same or different, is C 1 -C 4 alkyl and n is 2, 3 or 4.
Claim 7
Dependent Claim
82 words
An article having a surface which is to be brought into contact with body fluids, cells, tissues or a human or animal body, wherein said surface has been rendered biocompatible by treatment with a compound of the formula ##STR26## wherein X 1 is a reactive group which forms a covalent bond with a reactive group on said surface, and wherein each R, which may be the same or different, is C 1 -C 4 alkyl and n is 2, 3 or 4.
Claim 8
Dependent Claim
11 words
The article according to claim 5, wherein each R is methyl.
Claim 9
Dependent Claim
10 words
The article according to claim 5, wherein n is 2.
Claim 10
Dependent Claim
10 words
The article according to claim 6, wherein n is 2.
Claim 11
Dependent Claim
17 words
Ethylene glycol phosphatidylcholine of the formula ##STR27## wherein each R is methyl and wherein n is 2.
Claim 12
Dependent Claim
17 words
Ethylene glycol phosphatidylcholine of the formula ##STR27## wherein each R is methyl and wherein n is 2.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-01-09 | 1998-07-11 | 1999-01-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-01-09 | 2002-07-11 | 2003-01-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-01-09 | 2006-07-11 | 2007-01-10 | $7700.00 | Window Closed / Lapsed |