US5405317A
Expired / Lapsed
US
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Iontophoretic delivery device
Assignee: Alza Corp
•
Filing: 1991-05-07
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Granted: 1995-04-11
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Expires: 2011-05-07
Abstract
Abstract An electrically powered iontophoretic delivery device is provided. The device utilizes electrodes composed of a preferably hydrophobic polymeric matrix. The matrix contains about 10 to 50 vol % of a material capable of absorbing a liquid solvent, typically water, to provide a plurality of ion conducting pathways through the matrix. The matrix also contains about 5 to 40 vol % of a chemical species which is able to undergo either oxidation or reduction during operation of the device. Preferably, the solvent absorbing material is a hydrophilic polymer such as polyvinylpyrrolidone. For the anodic electrode, the chemical species should be able to undergo oxidation and is preferably either silver or zinc. For the cathodic electrode, the chemical species should be able to undergo reduction and is preferably silver chloride or a reducible metal.
Inventors
- 👤 Robert M. Myers
- 👤 Mark G. Stahl
- 👤 Felix A. Landrau
- 👤 J. Richard Gyory
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 11:25
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61N1/0432; A61N1/0436; A61N1/0448
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
139 words
An electrically powered iontophoretic delivery device including a donor electrode assembly, a counter electrode assembly and a source of electrical power adapted to be electrically connected to the donor electrode assembly and the counter electrode assembly, at least one of the electrode assemblies including an agent reservoir containing an agent, the agent reservoir adapted to be placed in agent transmitting relation with a body surface; and an electrode adapted to be electrically connected to the source of electrical power and to the agent reservoir; wherein the electrode comprises: a hydrophobic polymeric matrix; about 10 to 50 vol % of an agent which can absorb a liquid solvent thereby forming a plurality of ion-conducting pathways through the matrix; and about 5 to 40 vol % of a chemical species able to undergo oxidation or reduction during operation of the device.
Claim 2
Dependent Claim
139 words
An electrically powered iontophoretic delivery device including a donor electrode assembly, a counter electrode assembly and a source of electrical power adapted to be electrically connected to the donor electrode assembly and the counter electrode assembly, at least one of the electrode assemblies including an agent reservoir containing an agent, the agent reservoir adapted to be placed in agent transmitting relation with a body surface; and an electrode adapted to be electrically connected to the source of electrical power and to the agent reservoir; wherein the electrode comprises: a hydrophobic polymeric matrix; about 10 to 50 vol % of an agent which can absorb a liquid solvent thereby forming a plurality of ion-conducting pathways through the matrix; and about 5 to 40 vol % of a chemical species able to undergo oxidation or reduction during operation of the device.
Claim 3
Dependent Claim
29 words
The device of claim 1, wherein the electrode is an anode and the chemical species is an electrically conductive metal able to undergo oxidation during operation of the device.
Claim 4
Dependent Claim
18 words
The device of claim 2, wherein the metal is selected from the group consisting of silver and zinc.
Claim 5
Dependent Claim
25 words
The device of claim 1, wherein the electrode is a cathode and the chemical species is able to undergo reduction during operation of the device.
Claim 6
Dependent Claim
32 words
The device of claim 4, wherein the chemical species able to undergo reduction is an electrically conductive salt selected from the group consisting of AgCl, AgBr, and Ag 4 Fe(CN) 6 .
Claim 7
Dependent Claim
25 words
The device of claim 4, wherein the chemical species able to undergo reduction is electrically non-conductive and the matrix also contains an electrically conductive filler.
Claim 8
Dependent Claim
34 words
The device of claim 6, wherein the electrically nonconductive reducible species is selected from the group consisting of CuCl 2 and CuSO 4 and the conductive filler is comprised of a metal or carbon.
Claim 9
Dependent Claim
15 words
The device of claim 1, wherein the solvent-absorbing agent is substantially insoluble in the solvent.
Claim 10
Dependent Claim
15 words
The device of claim 1, wherein the solvent absorbing agent comprises a water-insoluble hydrophilic polymer.
Claim 11
Dependent Claim
30 words
The device of claim 9, wherein the hydrophilic polymer is selected from the group consisting of polyvinylpyrrolidones, polyethylene oxides, polyvinyl alcohols, cellulose derivatives, insoluble starch derivatives, hydrogels and mixtures thereof.
Claim 12
Dependent Claim
35 words
The device of claim 1, wherein the hydrophobic polymeric matrix is selected from the group consisting of ethylene vinyl acetate copolymers, polyalkylenes, polyisoprenes, rubbers including polyisobutylenes, polyamides, polyurethanes, polyvinylchlorides, modified cellulosic polymers and mixtures thereof.
Claim 13
Dependent Claim
17 words
The device of claim 1, wherein the hydrophobic polymer matrix is in the form of a film.
Claim 14
Dependent Claim
108 words
The device of claim 1, wherein the counter electrode assembly includes a counter electrode adapted to be electrically connected to the source of electrical power and an electrolyte reservoir adapted to be placed in electrolyte transmitting relation with the body surface, the counter electrode being in electrical contact with the electrolyte reservoir; wherein the counter electrode comprises: a hydrophobic polymeric matrix; about 10 to 50 vol % of an agent which can absorb a liquid solvent thereby forming a plurality of ion-conducting pathways through the matrix; and about 5 to 40 vol % of a chemical species able to undergo oxidation or reduction during operation of the device.
Claim 15
Dependent Claim
45 words
The device of claim 13, wherein the electrolyte reservoir is a polymeric matrix comprised of about 10 to 60 wt % of a hydrophilic polymer about 10 to 60 wt % of a hydrophobic polymer and up to about 50 wt % of the electrolyte.
Claim 16
Dependent Claim
55 words
The device of claim 1, wherein the donor electrode assembly includes a donor electrode adapted to be electrically connected to the source of electrical power and a drug reservoir adapted to be placed in drug transmitting relation with the body surface, the donor electrode having a surface which is in contact with the drug reservoir.
Claim 17
Dependent Claim
45 words
The device of claim 15, wherein the drug reservoir is a polymeric matrix comprised of about 10 to 60 wt % of a hydrophilic polymer, about 10 to 60 wt % of a hydrophobic polymer and up to about 50 wt % of the drug.
Claim 18
Dependent Claim
12 words
The device of claim 1, wherein the power source comprises a battery.
Claim 19
Dependent Claim
11 words
The device of claim 1, wherein the agent comprises a drug.
Claim 20
Dependent Claim
14 words
The device of claim 18, wherein the drug is a water soluble drug salt.
Claim 21
Dependent Claim
11 words
The device of claim 1, wherein the agent comprises an electrolyte.
Claim 22
Dependent Claim
14 words
The device of claim 20, wherein the electrolyte comprises a water soluble electrolyte salt.
Claim 23
Dependent Claim
27 words
The device of claim 1, wherein the liquid solvent absorbing agent and the chemical species able to undergo oxidation or reduction are one and the same material.
Claim 24
Dependent Claim
11 words
The device of claim 22, wherein said material comprises silver chloride.
Claim 25
Dependent Claim
11 words
The device of claim 22, wherein said material comprises silver/silver chloride.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-04-10 | 1998-10-10 | 1999-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-10 | 2002-10-10 | 2003-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-10 | 2006-10-10 | 2007-04-11 | $7700.00 | Window Closed / Lapsed |