US5405919A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
Assignee: United States Department of Health and Human Services
•
Filing: 1992-08-24
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Granted: 1995-04-11
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Expires: 2012-08-24
Abstract
Abstract A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.
Inventors
- 👤 Larry K. Keefer
- 👤 Joseph A. Hrabie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 18:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/655; A61K31/74; A61K31/785; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/59; A61K47/61; A61K47/62; A61K47/64; C; C08; C08F; C08F8/00; C08F8/30; C08F8/32
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
100 words
A polymer capable of releasing nitric oxide, said polymer comprising a polymeric backbone, wherein said polymeric backbone is of a polymer selected from the group consisting of a polyolefin, a polyether, a polyester, a polyamide, a polyurethane, a peptide, and a starburst dendrimer, and at least one nitric oxide-releasing [N 2 O 2 ] functional group selected from the group consisting of X--N(O)NO] or [N(O)NO--X, wherein X is an organic moiety covalently bonded to said [N 2 O 2 ], and wherein the [N 2 O 2 ] group is covalently bonded in said polymer through said organic moiety X.
Claim 2
Dependent Claim
100 words
A polymer capable of releasing nitric oxide, said polymer comprising a polymeric backbone, wherein said polymeric backbone is of a polymer selected from the group consisting of a polyolefin, a polyether, a polyester, a polyamide, a polyurethane, a peptide, and a starburst dendrimer, and at least one nitric oxide-releasing [N 2 O 2 ] functional group selected from the group consisting of X--N(O)NO] or [N(O)NO--X, wherein X is an organic moiety covalently bonded to said [N 2 O 2 ], and wherein the [N 2 O 2 ] group is covalently bonded in said polymer through said organic moiety X.
Claim 3
Dependent Claim
20 words
The polymer of claim 1 wherein the organic moiety X of said functional group is part of the polymer backbone.
Claim 4
Dependent Claim
24 words
The polymer of claim 1 wherein the organic moiety X of said functional group is part of a group pendant to said polymer backbone.
Claim 5
Dependent Claim
13 words
The polymer of claim 1, wherein said polymeric backbone is of a polyolefin.
Claim 6
Dependent Claim
10 words
The polymer of claim 4 wherein said polyolefin is polystyrene.
Claim 7
Dependent Claim
10 words
The polymer of claim 4 wherein said polyolefin is polyethylene.
Claim 8
Dependent Claim
10 words
The polymer of claim 4 wherein said polyolefin is polytetrafluoroethylene.
Claim 9
Dependent Claim
11 words
The polymer of claim 4 wherein said polyolefin is polyvinylidene difluoride.
Claim 10
Dependent Claim
10 words
The polymer of claim 4 wherein said polyolefin is polyvinylchloride.
Claim 11
Dependent Claim
10 words
The polymer of claim 4 wherein said polyolefin is polypropylene.
Claim 12
Dependent Claim
10 words
The polymer of claim 4, wherein said polyolefin is polyethyleneimine.
Claim 13
Dependent Claim
13 words
The polymer of claim 1 wherein said polymeric backbone is of a polyether.
Claim 14
Dependent Claim
13 words
The polymer of claim 1 wherein said polymeric backbone is of a polyester.
Claim 15
Dependent Claim
13 words
The polymer of claim 1 wherein said polymeric backbone is of a polyurethane.
Claim 16
Dependent Claim
13 words
The polymer of claim 1 wherein said polymeric backbone is of a peptide.
Claim 17
Dependent Claim
14 words
The polymer of claim 1 wherein said polymeric backbone is of a starburst dendrimer.
Claim 18
Dependent Claim
13 words
The polymer of claim 1 wherein said polymeric backbone is of a polyamide.
Claim 19
Dependent Claim
10 words
The polymer of claim 17 wherein said polyamide is nylon.
Claim 20
Dependent Claim
35 words
The polymer of claim 1 wherein said organic moiety X of the group X--N(O)NO] is of an amine selected from the group consisting of a primary amine, a secondary amine, a polyamine and derivatives thereof.
Claim 21
Dependent Claim
35 words
The polymer of claim 2 wherein said organic moiety X of the group X--N(O)NO] is of an amine selected from the group consisting of a primary amine, a secondary amine, a polyamine and derivatives thereof.
Claim 22
Dependent Claim
35 words
The polymer of claim 3 wherein said organic moiety X of the group X--N(O)NO] is of an amine selected from the group consisting of a primary amine, a secondary amine, a polyamine and derivatives thereof.
Claim 23
Dependent Claim
32 words
A polymer capable of releasing nitric oxide, said polymer comprising a polymeric backbone of polyethyleneimine and at least one nitric oxide releasing group having the formula [N2O 2 ] covalently bonded thereto.
Claim 24
Dependent Claim
32 words
A polymer capable of releasing nitric oxide, said polymer comprising a polymeric backbone of polyethyleneimine and at least one nitric oxide releasing group having the formula [N2O 2 ] covalently bonded thereto.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-04-10 | 1998-10-10 | 1999-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-10 | 2002-10-10 | 2003-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-10 | 2006-10-10 | 2007-04-11 | $7700.00 | Window Closed / Lapsed |