US5455329A
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DNA sequences coding for PTH variants, PTH variants, expression vector, bacterial host, use and therapeutic composition
Assignee: Helmholtz Centre for Infection Research
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Filing: 1992-10-29
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Granted: 1995-10-03
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Expires: 2012-10-29
Abstract
Abstract The invention relates to DNA sequences coding for PTH variants, to PTH variants, expression vectors, bacterial hosts, uses and therapeutic compositions.
Inventors
- 👤 Edgar Wingender
- 👤 Heiko Mielke
- 👤 Gisela Bercz-Timm
- 👤 Klaus-Dieter Schluter
- 👤 Hubert Mayer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 20:25
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/635; A; A61; A61P; A61P3/00; A61P43/00; A61K; A61K38/00; C07K2319/00; C07K2319/61; C07K2319/70; C07K2319/74; C07K2319/75
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
61 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 1 to 27, and which is lengthened N-terminally (position +1) by one or two amino acids, the amino acids coded by the DNA sequence not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 2
Dependent Claim
61 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 1 to 27, and which is lengthened N-terminally (position +1) by one or two amino acids, the amino acids coded by the DNA sequence not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 3
Dependent Claim
56 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 28 to 31, and which is lengthened N-terminally (position +1) by one or two amino acids, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 4
Dependent Claim
56 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 28 to 31, and which is lengthened N-terminally (position +1) by one or two amino acids, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 5
Dependent Claim
67 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 30 to 34, except that tyrosine may not appear at position 34, and, further which is optionally lengthened N-terminally (position +1) by one or two amino acids, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 6
Dependent Claim
67 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 30 to 34, except that tyrosine may not appear at position 34, and, further which is optionally lengthened N-terminally (position +1) by one or two amino acids, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 7
Dependent Claim
29 words
A variant of PTH(1-84) according to claim 3, in which one or two amino acids are exchanged for another amino acid in the region of positions 32 to 34.
Claim 8
Dependent Claim
18 words
A variant according to any one of claims 1, 2, 3, 4 which is lengthened N-terminally by proline.
Claim 9
Dependent Claim
54 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 1 to 27, and which is shortened C-terminally (position +84) by one amino acid, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 10
Dependent Claim
54 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 1 to 27, and which is shortened C-terminally (position +84) by one amino acid, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 11
Dependent Claim
54 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 28 to 31, and which is shortened C-terminally (position +84) by one amino acid, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 12
Dependent Claim
54 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 28 to 31, and which is shortened C-terminally (position +84) by one amino acid, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 13
Dependent Claim
64 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 30 to 34, except that tyrosine may not appear at position 34, and, further which is shortened C-terminally (position +84) by one amino acid, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 14
Dependent Claim
64 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 30 to 34, except that tyrosine may not appear at position 34, and, further which is shortened C-terminally (position +84) by one amino acid, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 15
Dependent Claim
29 words
A variant of PTH(1-84) according to claim 8, in which one or two amino acids are exchanged for another amino acid in the region of positions 32 to 34.
Claim 16
Dependent Claim
90 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 28 to 34 except that tyrosine may not appear at position 34 and, in addition one or two amino acids are exchanged for another amino acid outside the region of positions 28 to 34 and which is optionally shortened N-terminally (position +1) and C-terminally (position +84) by one amino acid, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 17
Dependent Claim
90 words
A variant of PTH(1-84), in which one or two amino acids are exchanged for another amino acid in the region of positions 28 to 34 except that tyrosine may not appear at position 34 and, in addition one or two amino acids are exchanged for another amino acid outside the region of positions 28 to 34 and which is optionally shortened N-terminally (position +1) and C-terminally (position +84) by one amino acid, the amino acids not being arranged in a sequence that occurs in bPTH, pPTH, rPTH, cPTH or hPTH.
Claim 18
Dependent Claim
19 words
A variant of PTH (1-84) according to claim 10 wherein said region is of positions of 30 to 34.
References Cited (Backward Citations)
No citation records indexed.
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| 3.5 Years (Year 4) | 1998-10-02 | 1999-04-03 | 1999-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-02 | 2003-04-03 | 2003-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-02 | 2007-04-03 | 2007-10-03 | $7700.00 | Window Closed / Lapsed |