US5456835A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device and process for removing free hemoglobin from blood
Assignee: Pall Corp
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Filing: 1993-11-08
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Granted: 1995-10-10
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Expires: 2013-11-08
Abstract
Abstract A filter and a hollow-fiber or flat-sheet membrane for removing hemoglobin from whole blood or blood fractions are disclosed. The filter comprises a laid textile web which has been modified to attach a ligand for hemoglobin. The membrane comprises a polyethersulfone membrane that has been similarly modified. Methods for removing hemoglobin, cellular components and debris from blood are also disclosed.
Inventors
- 👤 Franco Castino
- 👤 Abdul R. M. Azad
- 👤 Eric K. Lee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 14:17
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0093; B01D67/00931; B01D39/00; B01D39/14; B01D39/16; B01D39/1607; B01D39/1623; B01D69/00; B01D69/08; B01D71/00; B01D71/06; B01D71/66; B01D71/68; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/261; B01J20/262; B01J20/264; B01J20/28; B01J20/28014; B01J20/28023; B01J20/28028; B01J20/28033; B01J20/30; B01J20/32; B01J20/3202; B01J20/3206; B01J20/3208; B01J20/3212; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3248; B01J20/3251; B01J20/3255; B01J20/3291; B01J20/3293; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5002; A; A61; A61M; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/813; Y10S530/814; Y10S530/815; Y10S530/816; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
204 words
A filter for removing hemoglobin from whole blood or a blood fraction, comprising a shape-sustaining laid textile web having a thickness of 1 to 8 mm and a bulk density of 0.05 to 0.4 g/cm 3 , said web comprising: (a) a plurality of interlocked textile fibers with average deniers between 0.05 and 0.75 and average lengths between 3 mm and 15 mm, said textile fibers being substantially uniformly distributed in said web so as to form a matrix of the textile fibers with spaces between adjacent interstices of interlocked fibers; and (b) a plurality of fibrillated particles of surface-modified polymeric material having a surface area of 5 to 60 square meters per gram substantially disposed within said spaces of the matrix, said fibrillated particles having a plurality of fine fibrils which are interlocked with adjacent textile fibers of said spaces such that the fibrillated particles are not substantially displaceable from said web during filtration of said blood; wherein the weight ratio of the fibrillated particles to the textile fibers is between 1:99 and 40:60; and wherein said surface-modified polymeric material is cellulose acetate covalently linked to a ligand for hemoglobin; and wherein said textile fibers are hemolytically inert and stable to alkaline hydrolysis.
Claim 2
Dependent Claim
204 words
A filter for removing hemoglobin from whole blood or a blood fraction, comprising a shape-sustaining laid textile web having a thickness of 1 to 8 mm and a bulk density of 0.05 to 0.4 g/cm 3 , said web comprising: (a) a plurality of interlocked textile fibers with average deniers between 0.05 and 0.75 and average lengths between 3 mm and 15 mm, said textile fibers being substantially uniformly distributed in said web so as to form a matrix of the textile fibers with spaces between adjacent interstices of interlocked fibers; and (b) a plurality of fibrillated particles of surface-modified polymeric material having a surface area of 5 to 60 square meters per gram substantially disposed within said spaces of the matrix, said fibrillated particles having a plurality of fine fibrils which are interlocked with adjacent textile fibers of said spaces such that the fibrillated particles are not substantially displaceable from said web during filtration of said blood; wherein the weight ratio of the fibrillated particles to the textile fibers is between 1:99 and 40:60; and wherein said surface-modified polymeric material is cellulose acetate covalently linked to a ligand for hemoglobin; and wherein said textile fibers are hemolytically inert and stable to alkaline hydrolysis.
Claim 3
Dependent Claim
33 words
A filter according to claim 1 wherein said ligand for hemoglobin is selected from the group consisting of inositol hexaphosphate, adenosine triphosphate (ATP), pyridoxal phosphate, 2,3-diphosphoglycerate (DPG), adenosine diphosphate (ADP), and adenosine phosphate.
Claim 4
Dependent Claim
13 words
A filter according to claim 2 wherein said ligand is ATP or DPG.
Claim 5
Dependent Claim
21 words
A filter according to claim 1 wherein said ligand is attached to said cellulose acetate via a dihydrazide or diamine linker.
Claim 6
Dependent Claim
12 words
A filter according to claim 4 wherein said linker is adipic dihydrazide.
Claim 7
Dependent Claim
26 words
A filter according to claim 1 wherein said textile fibers are one or more of polyolefin, polyamide, polysulfone, polyester, polyvinyl alcohol, and poly(ethylene-vinyl alcohol) copolymer fibers.
Claim 8
Dependent Claim
13 words
A filter according to claim 6 wherein said textile fibers are polyolefin fibers.
Claim 9
Dependent Claim
23 words
A method for removing hemoglobin from whole blood or a blood fraction comprising passing said blood through a filter according to claim 3.
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