US5496360A — Implantable cardiac electrode with rate controlle…

Claim 1

Independent Claim 98 words

An implantable device, comprising: an electrode for implantation in a patient, said electrode having a reservoir located within said electrode; an insulated conductor having a distal end and a proximal end and coupled to said electrode at said distal end of said conductor and having a connector at said proximal end of said conductor; at least one therapeutic drug carried in said reservoir; and at least one drawing agent contained in said reservoir, having an ability to draw body fluid into said reservoir for modulating drug delivery rate of said at least one therapeutic drug to body tissue.

Claim 2

Dependent Claim 98 words

An implantable device, comprising: an electrode for implantation in a patient, said electrode having a reservoir located within said electrode; an insulated conductor having a distal end and a proximal end and coupled to said electrode at said distal end of said conductor and having a connector at said proximal end of said conductor; at least one therapeutic drug carried in said reservoir; and at least one drawing agent contained in said reservoir, having an ability to draw body fluid into said reservoir for modulating drug delivery rate of said at least one therapeutic drug to body tissue.

Claim 3

Dependent Claim 11 words

The implantable device of claim 1, wherein said agent is hydrophilic.

Claim 4

Dependent Claim 11 words

The implantable device of claim 1, wherein said agent is lipophilic.

Claim 5

Dependent Claim 22 words

The implantable device of claim 1, wherein more than one said agent is contained in said reservoir to provide different pumping effects.

Claim 6

Dependent Claim 13 words

The implantable device of claim 2 wherein said hydrophilic agent is a salt.

Claim 7

Dependent Claim 13 words

The implantable device of claim 2 wherein said hydrophilic agent is a protein.

Claim 8

Dependent Claim 25 words

The implantable device of claim 1 and further including a polymeric matrix within said reservoir, wherein said drawing agent is impregnated in said polymeric matrix.

Claim 9

Dependent Claim 12 words

The implantable device of claim 7 wherein said polymeric matrix is biodegradable.

Claim 10

Dependent Claim 29 words

The implantable device of claim 2 and further including a polymeric matrix within said reservoir, wherein said hydrophilic agent comprises a hydrophilic species chemically attached to said polymeric matrix.

Claim 11

Dependent Claim 25 words

The implantable device of claim 1 and further including a polymeric matrix within said reservoir, wherein said therapeutic drug is impregnated in said polymeric matrix.

Claim 12

Dependent Claim 12 words

The implantable device of claim 9 wherein said polymeric matrix is biodegradable.

Claim 13

Dependent Claim 14 words

The implantable device of claim 1 wherein said therapeutic drug is in liquid form.

Claim 14

Dependent Claim 72 words

The implantable device of claim 1, wherein said drawing agent is impregnated in a first polymeric matrix, and said therapeutic drug is impregnated in a second polymeric matrix, and said drug and said drawing agent are separated by an impermeable membrane, said first polymeric matrix expanding upon solvation of said drawing agent to press on said drug and said second polymeric matrix with said impermeable membrane, causing said drug to be dispensed.

Claim 15

Dependent Claim 20 words

The implantable device of claim 1 wherein said drug and said drawing agent are mixed together into a polymeric matrix.

Claim 16

Dependent Claim 29 words

The implantable device of claim 1, and further comprising a barrier layer containing a drawing agent which must be dissolved before said drug can be dissolved to begin elution.

Claim 17

Dependent Claim 56 words

A pump for dispensing a therapeutic drug to a patient's body, comprising: a chamber containing a polymeric matrix, a therapeutic drug, and a hydrophilic agent, wherein said hydrophilic agent is embedded in said polymeric matrix; an electrically insulating material forming an outer wall of said chamber; and an electrode forming an inner wall of said chamber.

Claim 18

Dependent Claim 56 words

A pump for dispensing a therapeutic drug to a patient's body, comprising: a chamber containing a polymeric matrix, a therapeutic drug, and a hydrophilic agent, wherein said hydrophilic agent is embedded in said polymeric matrix; an electrically insulating material forming an outer wall of said chamber; and an electrode forming an inner wall of said chamber.

Claim 19

Dependent Claim 18 words

The pump of claim 16 wherein said electrode has a channel from said chamber to said patient's body.

Claim 20

Dependent Claim 88 words

A body implantable lead comprising: an electrode for sensing or stimulation for implantation in a patient's body; an insulated conductor having a distal end and a proximal end and coupled to said electrode at said distal end of said conductor and having a connector at said proximal end of said conductor; and a drug eluting system located within said electrode having at least one therapeutic drug and at least one fluid drawing agent for use as a pump for delivering said at least one therapeutic drug to tissue.

Claim 21

Dependent Claim 88 words

A body implantable lead comprising: an electrode for sensing or stimulation for implantation in a patient's body; an insulated conductor having a distal end and a proximal end and coupled to said electrode at said distal end of said conductor and having a connector at said proximal end of said conductor; and a drug eluting system located within said electrode having at least one therapeutic drug and at least one fluid drawing agent for use as a pump for delivering said at least one therapeutic drug to tissue.

Claim 22

Dependent Claim 22 words

The lead of claim 18, wherein said drug eluting system has a plurality of fluid drawing agents to provide different pumping effects.

Claim 23

Dependent Claim 12 words

The lead of claim 18 wherein said fluid drawing agent is lipophilic.

Claim 24

Dependent Claim 27 words

The body implantable lead of claim 18 and further comprising a polymeric matrix within said electrode, wherein said fluid drawing agent is impregnated in said polymeric matrix.

Claim 25

Dependent Claim 24 words

The lead of claim 18 and further comprising a polymeric matrix within said electrode, wherein said therapeutic drug is impregnated in said polymeric matrix.

Claim 26

Dependent Claim 11 words

The lead of claim 22 wherein said polymeric matrix is biodegradable.

Claim 27

Dependent Claim 44 words

The lead of claim 18 wherein said therapeutic drug and said fluid drawing agent are separated by an impermeable membrane, said fluid drawing agent expanding upon drawing of fluid to press on said drug with said impermeable membrane, causing said drug to be dispensed.

Claim 28

Dependent Claim 43 words

The lead of claim 18, and further comprising a chamber containing said drug and a fluid drawing agent which is embedded in a polymeric matrix, said chamber having an electrically insulating material forming an outer wall and said electrode forming an inner wall.

Claim 29

Dependent Claim 18 words

The lead of claim 25 wherein said electrode has a channel from said chamber to the patient's body,.

Claim 30

Dependent Claim 12 words

The lead of claim 25 wherein said electrically insulating material is semipermeable.

Claim 31

Dependent Claim 116 words

A drug eluting system for use in an implantable electrode comprising: a porous electrode; an outer chamber formed by a semipermeable electrically insulating material and containing at least one therapeutic drug; an inner chamber formed by a semipermeable membrane and containing a hydrophilic agent for use as an osmotic pump for delivering said at least one therapeutic drug to tissue; an impermeable membrane separating said outer chamber from said inner chamber, said semipermeable membrane allowing body fluid to pass through to said inner chamber, said hydrophilic agent expanding upon hydration to press on said drug with said impermeable membrane, causing said drug to be dispensed through said semipermeable electrically insulating material and through said porous electrode.

Claim 32

Dependent Claim 116 words

A drug eluting system for use in an implantable electrode comprising: a porous electrode; an outer chamber formed by a semipermeable electrically insulating material and containing at least one therapeutic drug; an inner chamber formed by a semipermeable membrane and containing a hydrophilic agent for use as an osmotic pump for delivering said at least one therapeutic drug to tissue; an impermeable membrane separating said outer chamber from said inner chamber, said semipermeable membrane allowing body fluid to pass through to said inner chamber, said hydrophilic agent expanding upon hydration to press on said drug with said impermeable membrane, causing said drug to be dispensed through said semipermeable electrically insulating material and through said porous electrode.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1999-03-05	1999-09-04	2000-03-05	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2003-03-05	2003-09-04	2004-03-05	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2007-03-05	2007-09-04	2008-03-05	$7700.00	Window Closed / Lapsed

Implantable cardiac electrode with rate controlled drug delivery

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