US5518623A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hemodialysis monitoring system for hemodialysis machines
Assignee: Baxter International Inc
•
Filing: 1994-05-09
•
Granted: 1996-05-21
•
Expires: 2014-05-09
Abstract
Abstract An improved on-line real time hemodialysis monitoring system for hemodialysis treatment. The hemodialysis monitoring system quantitates the rate and amount of a constituent, such as urea, removed during the hemodialysis treatment by measuring the constituent concentrations as a function of time in the spent dialysate effluent from a hemodialysis machine. A quantity of the spent dialysate effluent is removed from the dialysate effluent waste line periodically for testing. A urea concentration time profile can be analyzed to determined the urea removal, KT/V, URR, SRI and normalized protein catabolic rate (nPCR) indices. The hemodialysis monitoring system preferably can obtain a dialysate sample equilibrated with the blood prior to the start of a hemodialysis treatment. The hemodialysis monitoring system includes a two pool analysis for taking into account the constituent concentration differences in the extracellular and intracellular spaces in the hemodialysis patient during the hemodialysis treatment.
Inventors
- 👤 Prakash Keshaviah
- 👤 James P. Ebben
- 👤 Paul F. Emerson
- 👤 David A. Luhring
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:09
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1601; A61M1/1603; A61M1/1605; A61M1/1609; A61M1/1613; A61M1/1615; A61M1/1619; A61M1/1621; A61M1/165; A61M1/36; A61M1/3607; A61M1/3609; A61M2202/00; A61M2202/04; A61M2202/0496; A61M2202/0498; A61M2205/00; A61M2205/15; A61M2205/33; A61M2205/3331; A61M2205/3334; Y; Y10; Y10T; Y10T436/00; Y10T436/17; Y10T436/171538
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
129 words
A method of monitoring a hemodialysis treatment in real time for utilization with a hemodialysis machine including a dialyzer and with dialysate waste effluent removed from the dialyzer, comprising: providing a dialysate effluent constituent sensor and separately coupling a plurality of separate fluid portions of the dialysate effluent to said constituent sensor during a dialysis treatment; detecting and measuring concentrations of said constituent in each of said dialysate effluent portions; determining a dialysate constituent concentration-time profile from said dialysate constituent concentration measurements; forming at least a two pool analysis to account for the differences in the constituent concentration in the extracellular and the intracellular spaces in a patient during the dialysis treatment; and directly determining an indication of adequacy of said dialysis treatment from said dialysate constituent concentration-time profile.
Claim 2
Independent Claim
129 words
A method of monitoring a hemodialysis treatment in real time for utilization with a hemodialysis machine including a dialyzer and with dialysate waste effluent removed from the dialyzer, comprising: providing a dialysate effluent constituent sensor and separately coupling a plurality of separate fluid portions of the dialysate effluent to said constituent sensor during a dialysis treatment; detecting and measuring concentrations of said constituent in each of said dialysate effluent portions; determining a dialysate constituent concentration-time profile from said dialysate constituent concentration measurements; forming at least a two pool analysis to account for the differences in the constituent concentration in the extracellular and the intracellular spaces in a patient during the dialysis treatment; and directly determining an indication of adequacy of said dialysis treatment from said dialysate constituent concentration-time profile.
Claim 3
Dependent Claim
42 words
The method as defined in claim 1 including said constituent being related to urea and providing a urea sensor to determine a urea concentration-time profile and determining at least one of urea removal, KT/V, PCR and URR from said urea concentration-time profile.
Claim 4
Dependent Claim
37 words
The method as defined in claim 2 including obtaining an equilibrated urea concentration measurement prior to starting the dialysis treatment and determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 5
Dependent Claim
36 words
The method as defined in claim 2 including obtaining an equilibrated urea concentration measurement after completing the dialysis treatment and determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 6
Dependent Claim
62 words
The method as defined in claim 2 including projecting a final urea concentration value for the completion of the dialysis treatment from said urea concentration-time profile at a point in time significantly prior to completing said dialysis treatment and projecting at least one of urea removal, KT/V, URR, PCR and a solute removal index (SRI) from said projected final urea concentration value.
Claim 7
Dependent Claim
22 words
The method as defined in claim 2 including calculating at least one of KT/V, PCR and URR from said two pool analysis.
Claim 8
Dependent Claim
24 words
The method as defined in claim 6 including forming two separate exponential fits of said urea concentration measurements to determine said urea concentration-time profile.
Claim 9
Dependent Claim
23 words
The method as defined in claim 6 including fitting said urea concentration measurements to a nonlinear function to describe said urea concentration-time profile.
Claim 10
Dependent Claim
37 words
The method as defined in claim 6 including obtaining an equilibrated urea concentration measurement prior to starting the dialysis treatment and determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 11
Dependent Claim
36 words
The method as defined in claim 6 including obtaining an equilibrated urea concentration measurement after completing the dialysis treatment and determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 12
Dependent Claim
58 words
The method as defined in claim 6 including projecting at least one of a final urea concentration value, final urea removal, final KT/V, final PCR, final URR and a final solute removal index (SRI) for the completion of the dialysis treatment from said urea concentration-time profile at a point in time significantly prior to completing said dialysis treatment.
Claim 13
Dependent Claim
21 words
The method as defined in claim 1 wherein said dialysate constituent time concentration profile is utilized for conducting a protein assessment.
Claim 14
Independent Claim
138 words
An apparatus adapted for monitoring a hemodialysis treatment in real time for utilization with a hemodialysis machine including a dialyzer and with dialysate waste effluent removed from the dialyzer, comprising: a dialysate effluent constituent sensor and means for separately coupling a plurality of separate fluid portions of the dialysate effluent to said constituent sensor during a dialysis treatment; means for detecting and measuring concentrations of said constituent in each of said dialysate effluent portions; means for determining a constituent concentration-time profile from said dialysate constituent concentration measurements; means for forming at least a two pool analysis to account for the differences in the constituent concentration in the extracellular and the intracellular spaces in a patient during the dialysis treatment; and means for directly determining an indication of adequacy of said dialysis treatment from said dialysate constituent concentration-time profile.
Claim 15
Independent Claim
138 words
An apparatus adapted for monitoring a hemodialysis treatment in real time for utilization with a hemodialysis machine including a dialyzer and with dialysate waste effluent removed from the dialyzer, comprising: a dialysate effluent constituent sensor and means for separately coupling a plurality of separate fluid portions of the dialysate effluent to said constituent sensor during a dialysis treatment; means for detecting and measuring concentrations of said constituent in each of said dialysate effluent portions; means for determining a constituent concentration-time profile from said dialysate constituent concentration measurements; means for forming at least a two pool analysis to account for the differences in the constituent concentration in the extracellular and the intracellular spaces in a patient during the dialysis treatment; and means for directly determining an indication of adequacy of said dialysis treatment from said dialysate constituent concentration-time profile.
Claim 16
Dependent Claim
44 words
The apparatus as defined in claim 13 including said constituent being related to urea and including a urea sensor to determine a urea concentration-time profile and means for determining at least one of urea removal, KT/V, PCR and URR from said urea concentration-time profile.
Claim 17
Dependent Claim
41 words
The apparatus as defined in claim 14 including means for obtaining an equilibrated urea concentration measurement prior to starting the dialysis treatment and means for determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 18
Dependent Claim
40 words
The apparatus as defined in claim 14 including means for obtaining an equilibrated urea concentration measurement after completing the dialysis treatment and means for determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 19
Dependent Claim
64 words
The apparatus as defined in claim 14 including means for projecting a final urea concentration measurement for the completion of the dialysis treatment from said urea concentration-time profile at a point in time significantly prior to completing said dialysis treatment and projecting at least one of urea removal, KT/V, URR, PCR and a solute removal index (SRI) from said projected final urea concentration value.
Claim 20
Dependent Claim
24 words
The apparatus as defined in claim 14 including means for calculating at least one of KT/V, PCR and URR from said two pool analysis.
Claim 21
Dependent Claim
26 words
The apparatus as defined in claim 18 including means for forming two separate exponential fits of said urea concentration measurements to determine said urea concentration-time profile.
Claim 22
Dependent Claim
25 words
The apparatus as defined in claim 18 including means for fitting said urea concentration measurements to a nonlinear function to describe said urea concentration-time profile.
Claim 23
Dependent Claim
41 words
The apparatus as defined in claim 18 including means for obtaining an equilibrated urea concentration measurement prior to starting the dialysis treatment and means for determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 24
Dependent Claim
40 words
The apparatus as defined in claim 18 including means for obtaining an equilibrated urea concentration measurement after completing the dialysis treatment and means for determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 25
Dependent Claim
60 words
The apparatus as defined in claim 18 including means for projecting at least one of a final urea concentration value, final urea removal, final KT/V, final PCR, final URR and a final solute removal index (SRI) for the completion of the dialysis treatment from said urea concentration-time profile at a point in time significantly prior to completing said dialysis treatment.
Claim 26
Dependent Claim
21 words
The apparatus as defined in claim 13 further comprising means for conducting protein assessment from the dialysate constituent time concentration profile.
Claim 27
Independent Claim
129 words
A method of monitoring a hemodialysis treatment in real time for utilization with a hemodialysis machine including a dialyzer and with dialysate waste effluent removed from the dialyzer, comprising: providing a dialysate effluent urea sensor and separately coupling a plurality of separate fluid portions of the dialysate effluent to said urea sensor during a dialysis treatment; detecting and measuring concentrations of said urea in each of said dialysate effluent portions; determining a dialysate urea concentration-time profile from said dialysate urea concentration measurements; forming at least a two pool analysis to account for the differences in the urea concentration in the extracellular and the intracellular spaces in a patient during the dialysis treatment; and directly determining an indication of adequacy of said dialysis treatment from said dialysate urea concentration-time profile.
Claim 28
Independent Claim
129 words
A method of monitoring a hemodialysis treatment in real time for utilization with a hemodialysis machine including a dialyzer and with dialysate waste effluent removed from the dialyzer, comprising: providing a dialysate effluent urea sensor and separately coupling a plurality of separate fluid portions of the dialysate effluent to said urea sensor during a dialysis treatment; detecting and measuring concentrations of said urea in each of said dialysate effluent portions; determining a dialysate urea concentration-time profile from said dialysate urea concentration measurements; forming at least a two pool analysis to account for the differences in the urea concentration in the extracellular and the intracellular spaces in a patient during the dialysis treatment; and directly determining an indication of adequacy of said dialysis treatment from said dialysate urea concentration-time profile.
Claim 29
Dependent Claim
24 words
The method as defined in claim 25 including determining at least one of urea removal, KT/V, URR and PCR from said urea concentration-time profile.
Claim 30
Dependent Claim
37 words
The method as defined in claim 25 including obtaining an equilibrated urea concentration measurement prior to starting the dialysis treatment and determining a solute removal index (SRD from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 31
Dependent Claim
36 words
The method as defined in claim 25 including obtaining an equilibrated urea concentration measurement after completing the dialysis treatment and determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 32
Dependent Claim
62 words
The method as defined in claim 25 including projecting a final urea concentration value for the completion of the dialysis treatment from said urea concentration-time profile at a point in time significantly prior to completing said dialysis treatment and projecting at least one of urea removal, KT/V, URR, PCR and a solute removal index (SRI) from said projected final urea concentration value.
Claim 33
Dependent Claim
22 words
The method as defined in claim 25 including calculating at least one of KT/V, PCR and URR from said two pool analysis.
Claim 34
Dependent Claim
24 words
The method as defined in claim 30 including forming two separate exponential fits of said urea concentration measurements to determine said urea concentration-time profile.
Claim 35
Dependent Claim
23 words
The method as defined in claim 30 including fitting said urea concentration measurements to a nonlinear function to describe said urea concentration-time profile.
Claim 36
Dependent Claim
37 words
The method as defined in claim 30 including obtaining an equilibrated urea concentration measurement prior to starting the dialysis treatment and determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 37
Dependent Claim
36 words
The method as defined in claim 30 including obtaining an equilibrated urea concentration measurement after completing the dialysis treatment and determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 38
Dependent Claim
58 words
The method as defined in claim 30 including projecting at least one of a final urea concentration value, final urea removal, final KT/V, final PCR, final URR and a final solute removal index (SRI) for the completion of the dialysis treatment from said urea concentration-time profile at a point in time significantly prior to completing said dialysis treatment.
Claim 39
Dependent Claim
21 words
The method as defined in claim 25 wherein said dialysate urea time concentration profile is utilized for conducting a protein assessment.
Claim 40
Independent Claim
138 words
An apparatus adapted for monitoring a hemodialysis treatment in real time for utilization with a hemodialysis machine including a dialyzer and with dialysate waste effluent removed from the dialyzer, comprising: a dialysate effluent urea sensor and means for separately coupling a plurality of separate fluid portions of the dialysate effluent to said urea sensor during a dialysis treatment; means for detecting and measuring concentrations of said urea in each of said dialysate effluent portions; means for determining a urea concentration-time profile from said dialysate urea concentration measurements; means for forming at least a two pool analysis to account for the differences in the urea concentration in the extracellular and the intracellular spaces in a patient during the dialysis treatment; and means for directly determining an indication of adequacy of said dialysis treatment from said urea dialysate concentration-time profile.
Claim 41
Independent Claim
138 words
An apparatus adapted for monitoring a hemodialysis treatment in real time for utilization with a hemodialysis machine including a dialyzer and with dialysate waste effluent removed from the dialyzer, comprising: a dialysate effluent urea sensor and means for separately coupling a plurality of separate fluid portions of the dialysate effluent to said urea sensor during a dialysis treatment; means for detecting and measuring concentrations of said urea in each of said dialysate effluent portions; means for determining a urea concentration-time profile from said dialysate urea concentration measurements; means for forming at least a two pool analysis to account for the differences in the urea concentration in the extracellular and the intracellular spaces in a patient during the dialysis treatment; and means for directly determining an indication of adequacy of said dialysis treatment from said urea dialysate concentration-time profile.
Claim 42
Dependent Claim
44 words
The apparatus as defined in claim 37 including said constituent being related to urea and including a urea sensor to determine a urea concentration-time profile and means for determining at least one of urea removal, KT/V, PCR and URR from said urea concentration-time profile.
Claim 43
Dependent Claim
41 words
The apparatus as defined in claim 37 including means for obtaining an equilibrated urea concentration measurement prior to starting the dialysis treatment and means for determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 44
Dependent Claim
40 words
The apparatus as defined in claim 37 including means for obtaining an equilibrated urea concentration measurement after completing the dialysis treatment and means for determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 45
Dependent Claim
64 words
The apparatus as defined in claim 37 including means for projecting a final urea concentration measurement for the completion of the dialysis treatment from said urea concentration-time profile at a point in time significantly prior to completing said dialysis treatment and projecting at least one of urea removal, KT/V, URR, PCR and a solute removal index (SRI) from said projected final urea concentration value.
Claim 46
Dependent Claim
24 words
The apparatus as defined in claim 34 including means for calculating at least one of KT/V, PCR and URR from said two pool analysis.
Claim 47
Dependent Claim
26 words
The apparatus as defined in claim 42 including means for forming two separate exponential fits of said urea concentration measurements to determine said urea concentration-time profile.
Claim 48
Dependent Claim
25 words
The apparatus as defined in claim 42 including means for fitting said urea concentration measurements to a nonlinear function to describe said urea concentration-time profile.
Claim 49
Dependent Claim
41 words
The apparatus as defined in claim 42 including means for obtaining an equilibrated urea concentration measurement prior to starting the dialysis treatment and means for determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 50
Dependent Claim
40 words
The apparatus as defined in claim 42 including means for obtaining an equilibrated urea concentration measurement after completing the dialysis treatment and means for determining a solute removal index (SRI) from said equilibrated concentration measurement and said urea concentration-time profile.
Claim 51
Dependent Claim
59 words
The apparatus as defined in claim 42 including means for at least one of a final urea concentration value, final urea removal, final KT/V, final PCR, final URR and a final solute removal index (SRI) for the completion of the dialysis treatment from said urea concentration-time profile at a point in time significantly prior to completing said dialysis treatment.
Claim 52
Dependent Claim
21 words
The apparatus as defined in claim 37 further comprising means for conducting protein assessment from the dialysate urea time concentration profile.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-05-21 | 1999-11-20 | 2000-05-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-05-21 | 2003-11-20 | 2004-05-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-05-21 | 2007-11-20 | 2008-05-21 | $7700.00 | Window Closed / Lapsed |