US5523348A
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US
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Method of preparing collagen-polymer conjugates
Assignee: Surgical Specialties US Corp
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Filing: 1994-08-18
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Granted: 1996-06-04
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Expires: 2014-08-18
Abstract
Abstract Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
Inventors
- 👤 Woonza Rhee
- 👤 Donald G. Wallace
- 👤 Alan S. Michaels
- 👤 Ramon A. Burns, Jr.
- 👤 Louis Fries
- 👤 Frank DeLustro
- 👤 Hanne Bentz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 02:04
CPC Classifications
C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; A61L27/28; A61L27/34; A61L27/40; A61L27/44; A61L27/50; A61L27/54; A61L31/00; A61L31/04; A61L31/041; A61L31/043; A61L31/044; A61L31/08; A61L31/10; A61L31/12; A61L31/125; C08H; C08H1/00; C08H1/06; C09; C09J; C09J189/00; C09J189/04; C09J189/06; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/426; A61L2300/60; A61L2300/602; A61L2430/00; A61L2430/02; A61L2430/16; C08L2666/00; C08L2666/02; Y; Y10; Y10S; Y10S525/00; Y10S525/935; Y10S525/937; Y10S530/00; Y10S530/827; Y10S530/84
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
125 words
A method for preparing a collagen-polymer conjugate suitable for administering to mammals, which method comprises: providing an aqueous mixture of collagen molecules, said mixture having a concentration of about 3 to about 100 mg/mL collagen; providing a solution of synthetic hydrophilic polymer molecules, wherein each polymer molecule has at least two reactive groups capable of forming a covalent bond with an available lysine chain present in said collagen molecules; and mixing said aqueous mixture of collagen molecules with said solution of synthetic hydrophilic polymer molecules to yield a reaction mixture having a hydrophilic polymer concentration of about 0.1% to about 50% by weight, thereby forming covalent bonds between said collagen molecules and said hydrophilic polymer molecules, said covalent bonds effecting crosslinking of said collagen molecules.
Claim 2
Independent Claim
125 words
A method for preparing a collagen-polymer conjugate suitable for administering to mammals, which method comprises: providing an aqueous mixture of collagen molecules, said mixture having a concentration of about 3 to about 100 mg/mL collagen; providing a solution of synthetic hydrophilic polymer molecules, wherein each polymer molecule has at least two reactive groups capable of forming a covalent bond with an available lysine chain present in said collagen molecules; and mixing said aqueous mixture of collagen molecules with said solution of synthetic hydrophilic polymer molecules to yield a reaction mixture having a hydrophilic polymer concentration of about 0.1% to about 50% by weight, thereby forming covalent bonds between said collagen molecules and said hydrophilic polymer molecules, said covalent bonds effecting crosslinking of said collagen molecules.
Claim 3
Dependent Claim
22 words
The method of claim 1 wherein said hydrophilic polymer comprises polyethylene glycol having a molecular weight of about 400 to about 20,000.
Claim 4
Dependent Claim
19 words
The method of claim 1 which further comprises: casting said reaction mixture into a desired shape during said crosslinking.
Claim 5
Dependent Claim
14 words
The method of claim 3 wherein said shape is a membrane or a tube.
Claim 6
Dependent Claim
19 words
The method of claim 1 which further comprises: applying said reaction mixture to a solid support during said crosslinking.
Claim 7
Dependent Claim
12 words
The method of claim 5 wherein said solid support comprises a catheter.
Claim 8
Dependent Claim
14 words
The method of claim 5 wherein said solid support comprises a stress-bearing bone implant.
Claim 9
Dependent Claim
25 words
The method of claim 1 wherein said reaction mixture is vigorously agitated during said mixing, providing said collagen-polymer conjugate in the form of a particulate.
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