US5540918A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of certain anionic surfactants to enhance antimicrobial effectiveness of ophthalmic compositions
Assignee: Alcon Research LLC
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Filing: 1995-06-07
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Granted: 1996-07-30
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Expires: 2015-06-07
Abstract
Abstract Certain anionic surfactants are used to enhance antimicrobial effectiveness in comfortable, sustained release ophthalmic compositions containing polyelectrolytes, such as carboxyvinyl polymers, polystyrene sulfonic acid polymers and cationic exchange resins, as well as at least one active ingredient.
Inventors
- 👤 Ernesto J. Castillo
- 👤 Yusuf Ali
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:48
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/08; A61K47/14; A61K47/16; A61K47/18; A61K47/183; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
107 words
An ophthalmic composition having enhanced or improved antimicrobial efficacy, said composition comprising a cationic antimicrobial, an anionic polyelectrolyte, a therapeutically-effective amount of an active ingredient, and an anionic surfactant, wherein said artionic surfactant is present in an amount effective to enhance the cationic antimicrobial's effectiveness and is selected from the group consisting of: a) a compound of formula: ##STR4## wherein: R 1 =C 4-C 27 saturated or unsaturated hydrocarbon; M=H or a pharmaceutically acceptable salt; and n=1,2 or 3; and b) a compound of formula: ##STR5## wherein: R 2 =C 4 -C 27 saturated or unsaturated hydrocarbon; M=H or a pharmaceutically acceptable salt; and n=1,2 or 3.
Claim 2
Dependent Claim
107 words
An ophthalmic composition having enhanced or improved antimicrobial efficacy, said composition comprising a cationic antimicrobial, an anionic polyelectrolyte, a therapeutically-effective amount of an active ingredient, and an anionic surfactant, wherein said artionic surfactant is present in an amount effective to enhance the cationic antimicrobial's effectiveness and is selected from the group consisting of: a) a compound of formula: ##STR4## wherein: R 1 =C 4-C 27 saturated or unsaturated hydrocarbon; M=H or a pharmaceutically acceptable salt; and n=1,2 or 3; and b) a compound of formula: ##STR5## wherein: R 2 =C 4 -C 27 saturated or unsaturated hydrocarbon; M=H or a pharmaceutically acceptable salt; and n=1,2 or 3.
Claim 3
Dependent Claim
23 words
The composition of claim 1, wherein the final composition concentration of said anionic surfactant is between about 0.005 and about 5.0 wt %.
Claim 4
Dependent Claim
15 words
The composition of claim 1, wherein said anionic surfactant comprises a compound of formula I.
Claim 5
Dependent Claim
22 words
The composition of claim 3, wherein the final composition concentration of said anionic surfactant is between about 0.01 and 0.5 wt %.
Claim 6
Dependent Claim
15 words
The composition of claim 1, wherein said anionic surfactant comprises a compound of formula II.
Claim 7
Dependent Claim
22 words
The composition of claim 5, wherein the final composition concentration of said anionic surfactant is between about 0.1 and 5.0 wt %.
Claim 8
Dependent Claim
32 words
The composition of claim 1, wherein said anionic surfactant is selected from the group consisting of lauroyl sarcosine, oleoyl sarcosine, myrstoyl sarcosine, cocoyl sarcosine, stearoyl sarcosine, pelargodoyl sarcosine and sodium capryl lactylate.
Claim 9
Dependent Claim
12 words
The composition of claim 1, wherein the active ingredient comprises a beta-blocker.
Claim 10
Dependent Claim
18 words
The composition of claim 8, wherein the beta-blocker is selected from the group consisting of betaxolol and timolol.
Claim 11
Dependent Claim
27 words
The composition of claim 1, wherein said polyelectrolyte is selected from the group consisting of: carboxyvinyl polymers, polystyrene sulfonic acid polymers and finely divided cationic exchange resins.
References Cited (Backward Citations)
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Cited
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Cited
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Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-07-30 | 2000-01-29 | 2000-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-07-30 | 2004-01-29 | 2004-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-07-30 | 2008-01-29 | 2008-07-30 | $7700.00 | Window Closed / Lapsed |