US5563292A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lipoxygenase inhibitors
Assignee: Merck Sharp & Dohme LLC
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Filing: 1990-10-17
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Granted: 1996-10-08
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Expires: 2010-10-17
Abstract
Abstract PCT No. PCT/US90/05824 Sec. 371 Date Apr. 2, 1992 Sec. 102(e) Date Apr. 2, 1992 PCT Filed Oct. 17, 1990Novel compounds of Formula 1 <IMAGE> (1) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Also disclosed are pharmaceutical compositions containing compounds of Formula 1. Methods of treating allergy, inflammation and hyperproliferative skin diseases with compounds of Formula 1 are also disclosed.
Inventors
- 👤 Neng-Yang Shih
- 👤 Pietro Mangiaracina
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 21:02
CPC Classifications
C; C07; C07C; C07C259/00; C07C259/04; C07C259/06; C07C43/00; C07C43/02; C07C43/20; C07C43/23; C07C45/00; C07C45/27; C07C45/29; C07C45/292; C07C47/00; C07C47/20; C07C47/277; C07C69/00; C07C69/007; C07C69/66; C07C69/73; C07C69/734
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
125 words
A compound having the formula 3: ##STR48## wherein: R 1 and R 2 are the same and are alkyl; R 3 is alkyl; R 4 is H; W is --(CH 2 ) n X; n is 3 or 4; when n is 4, X is --OR 10 or --OC(O)R 9 ; and when n is 3, then X is --C(O)R 11 , wherein R 11 is selected from H, OH, --OCH 3 and --NHOH; R 9 is selected from H, alkyl, aryl, substituted aryl, aralkyl, cycloalkyl, or heteroaryl, with the proviso that said heteroaryl group is bound through a ring carbon; R 10 is selected from H or alkyl: and R 14 and R 15 are the same or different and are selected from alkyl.
Claim 2
Dependent Claim
125 words
A compound having the formula 3: ##STR48## wherein: R 1 and R 2 are the same and are alkyl; R 3 is alkyl; R 4 is H; W is --(CH 2 ) n X; n is 3 or 4; when n is 4, X is --OR 10 or --OC(O)R 9 ; and when n is 3, then X is --C(O)R 11 , wherein R 11 is selected from H, OH, --OCH 3 and --NHOH; R 9 is selected from H, alkyl, aryl, substituted aryl, aralkyl, cycloalkyl, or heteroaryl, with the proviso that said heteroaryl group is bound through a ring carbon; R 10 is selected from H or alkyl: and R 14 and R 15 are the same or different and are selected from alkyl.
Claim 3
Dependent Claim
10 words
The compound of claim 1 having the formula 4: ##STR49##
Claim 4
Dependent Claim
21 words
The compound of claim 2 having formula 5: ##STR50## wherein X is selected from --C(O)H, --C(O)OH, --C(O)OCH 3 , or --C(O)NHOH.
Claim 5
Dependent Claim
18 words
The compound of claim 2 having the formula 6: ##STR51## wherein X is --OH or --OC(O)CH 3 .
Claim 6
Dependent Claim
25 words
A method of treating hyperproliferative skin disease in a mammal comprising administering to said mammal an antihyperproliferative effective amount of a compound of claim 3.
Claim 7
Dependent Claim
25 words
A method of treating hyperproliferative skin disease in a mammal comprising administering to said mammal an antihyperproliferative effective amount of a compound of claim 4.
Claim 8
Dependent Claim
11 words
The compound of claim 3 having a formula selected from: ##STR52##
Claim 9
Dependent Claim
9 words
The compound of claim 3 having the formula: ##STR53##
Claim 10
Dependent Claim
11 words
The compound of claim 4 having a formula selected from: ##STR54##
Claim 11
Dependent Claim
204 words
A compound of formula 3: ##STR55## wherein: R 1 and R 2 are the same and are alkyl; R 3 is alkyl; R 4 is H; W is --(CH 2 ) n X; n is 3 or 4; when n is 4, X is --OR 10 or --OC(O)R 9 ; and when n is 3, then X is --C(O)R 11 ; R 5 is selected from H, alkyl, aryl, alkaryl, aralkyl, cycloalkyl, or heteroaryl, with the proviso that said heteroaryl group is bound through a ring carbon; R 6 and R 7 are the same or different and are selected from H, alkyl, aryl, alkaryl, aralkyl, acyl, substituted aryl, cycloalkyl or heteroaryl, with the proviso that when R 6 and/or R 7 is a heteroaryl group said heteroaryl group is bound through a ring carbon; R 9 is selected from H, alkyl, aryl, substituted aryl, aralkyl, cycloalkyl, or heteroaryl, with the proviso that said heteroaryl group is bound through a ring carbon; R 10 is selected from H or alkyl; R 11 is selected from H, --OR 5 , --NR 6 R 7 , or --NR 5 OH; and R 14 and R 15 are the same or different and are selected from alkyl.
Claim 12
Dependent Claim
204 words
A compound of formula 3: ##STR55## wherein: R 1 and R 2 are the same and are alkyl; R 3 is alkyl; R 4 is H; W is --(CH 2 ) n X; n is 3 or 4; when n is 4, X is --OR 10 or --OC(O)R 9 ; and when n is 3, then X is --C(O)R 11 ; R 5 is selected from H, alkyl, aryl, alkaryl, aralkyl, cycloalkyl, or heteroaryl, with the proviso that said heteroaryl group is bound through a ring carbon; R 6 and R 7 are the same or different and are selected from H, alkyl, aryl, alkaryl, aralkyl, acyl, substituted aryl, cycloalkyl or heteroaryl, with the proviso that when R 6 and/or R 7 is a heteroaryl group said heteroaryl group is bound through a ring carbon; R 9 is selected from H, alkyl, aryl, substituted aryl, aralkyl, cycloalkyl, or heteroaryl, with the proviso that said heteroaryl group is bound through a ring carbon; R 10 is selected from H or alkyl; R 11 is selected from H, --OR 5 , --NR 6 R 7 , or --NR 5 OH; and R 14 and R 15 are the same or different and are selected from alkyl.
References Cited (Backward Citations)
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