Patent US2345399A successfully refreshed from Google Patents.
US5569754A
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RNA import elements for transport into mitochondria
Assignee: The University of Texas System
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Filing: 1993-06-11
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Granted: 1996-10-29
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Expires: 2013-06-11
Abstract
Abstract The invention relates to small RNAs encoded within the nucleus of mammalian cells that specifically import to the mitochondria. The RNAs bind to several nucleolar peptides and thus provide potential carriers for import of biological molecules, including metabolites and proteins, into the mitochondrial compartment. Mitochondrial dysfunction in several maternally inherited human diseases may be correctable employing linkage of mitochondrial import signal to mitochondrial tRNA sequences expressed from nuclear trans-genes without requirement for direct genetic transformation of mitochondria.
Inventors
- 👤 R. Sanders Williams
- 👤 Kang Li
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:43
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N9/00; C12N9/14; C12N9/16; C12N9/22
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
41 words
An isolated RNA encoded within the midportion of mammalian mitochondrial RNA-processing endoribonuclease RNA gene consisting of a coding region that imports into mitochondria but lacks transcriptional control elements selected from the group consisting of SEQ I.D. NOs. 1, 8, and 9.
Claim 2
Dependent Claim
41 words
An isolated RNA encoded within the midportion of mammalian mitochondrial RNA-processing endoribonuclease RNA gene consisting of a coding region that imports into mitochondria but lacks transcriptional control elements selected from the group consisting of SEQ I.D. NOs. 1, 8, and 9.
Claim 3
Dependent Claim
20 words
The isolated RNA of claim 1 which has the sequence of SEQ ID NO. 1 or SEQ ID NO: 8.
Claim 4
Dependent Claim
29 words
The isolated RNA of claim 1 wherein the midportion of the mammalian MRP-RNA gene consisting of 58 base pairs of coding region nt118 to 175, SEQ ID NO: 9.
Claim 5
Dependent Claim
15 words
A DNA segment which is fully complementary to any of the RNA of claims 1-3.
Claim 6
Dependent Claim
10 words
A recombinant vector comprising the DNA consisting of claim 4.
Claim 7
Dependent Claim
11 words
A recombinant cell transformed with the recombinant vector of claim 5.
Claim 8
Dependent Claim
11 words
The recombinant cell of claim 6 which is a eukaryotic cell.
Claim 9
Dependent Claim
11 words
The recombinant cell of claim 6 which is a myoblast cell.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-10-29 | 2000-04-29 | 2000-10-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-29 | 2004-04-29 | 2004-10-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-29 | 2008-04-29 | 2008-10-29 | $7700.00 | Window Closed / Lapsed |