US5593658A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medical compositions
Assignee: General Hospital Corp
•
Filing: 1994-05-27
•
Granted: 1997-01-14
•
Expires: 2014-05-27
Abstract
Abstract A biocompatible medical composition including a polymeric carrier, a protective chain linked to the polymeric carrier, and a reporter group linked to the carrier or to the carrier and the protective chain. The invention also relates to a method of treating a disease in a patient by administering to the patient a therapeutically effective amount of the composition, and may include scanning the patient using an imaging technique which can detect the reporter group to obtain a visible image of the distribution of the composition.
Inventors
- 👤 Alexei A. Bogdanov
- 👤 Thomas J. Brady
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 10:03
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/14; A61K49/146; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K47/62; A61K47/64; A61K47/645; A61K49/085; A61K49/12; A61K49/126; A61K49/128; A61K51/00; A61K51/02; A61K51/04; A61K51/06; A61K51/065; A61P; A61P25/00; A61P25/18; A61P29/00; A61P31/00; A61P31/12; A61P5/00; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10S977/00; Y10S977/84; Y10S977/895; Y10S977/896; Y10S977/898; Y10S977/902; Y10S977/904; Y10S977/915; Y10S977/927; Y10S977/93; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
77 words
A biocompatible medical composition comprising: a non-polysaccharide polymeric carrier; a plurality of protective chains linked to said polymeric carrier, wherein each protective chain is at least 500 Daltons; and a reporter group linked to said carrier and not linked to said protective chain, wherein said reporter group is a complexone or a therapeutic agent, and both said carrier and said reporter group are protected by said protective chains from contact with macromolecules other than in said composition.
Claim 2
Dependent Claim
77 words
A biocompatible medical composition comprising: a non-polysaccharide polymeric carrier; a plurality of protective chains linked to said polymeric carrier, wherein each protective chain is at least 500 Daltons; and a reporter group linked to said carrier and not linked to said protective chain, wherein said reporter group is a complexone or a therapeutic agent, and both said carrier and said reporter group are protected by said protective chains from contact with macromolecules other than in said composition.
Claim 3
Dependent Claim
29 words
The composition of claim 1, wherein said polymeric carrier is chosen from the group of polyamino acids, polyethyleneimines, natural saccharides, aminated polysaccharides, aminated oligosaccharides, polyamidoamine, polyacrylic acids, or polyalcohols.
Claim 4
Dependent Claim
14 words
The composition of claim 2, wherein said polyamino acid has 20-560 amino acid units.
Claim 5
Dependent Claim
16 words
The composition of claim 3, wherein said polyamino acid has a molecular weight of 1,000-100,000 daltons.
Claim 6
Dependent Claim
19 words
The composition of claim 2, wherein said polyamino acid is a polymer of a single species of amino acid.
Claim 7
Dependent Claim
21 words
The composition of claim 2, wherein said polyamino acid is a polymer of at least two different species of amino acids.
Claim 8
Dependent Claim
13 words
The composition of claim 2, wherein said polyamino acid is a block copolymer.
Claim 9
Dependent Claim
17 words
The composition of claim 2, wherein said polyamino acid comprises polyamino acid fragments linked by cleavable bonds.
Claim 10
Dependent Claim
12 words
The composition of claim 8, wherein said cleavable bonds are S--S bonds.
Claim 11
Dependent Claim
18 words
The composition of claim 2, wherein said polyamino acid is poly-l-lysine, poly-d-lysine, poly-alpha, beta-(2-aminoethyl)-D,L aspartamide, or poly-l-aspartic acid.
Claim 12
Dependent Claim
11 words
The composition of claim 2, wherein said polyamino acid is non-proteinaceous.
Claim 13
Dependent Claim
29 words
The composition of claim 1, wherein said protective chain is polyethylene glycol, methoxypolyethylene glycol, methoxypolypropylene glycol, a copolymer of polyethylene glycol, methoxypolyethylene glycol, or methoxypolypropylene glycol, or derivatives thereof.
Claim 14
Dependent Claim
29 words
The composition of claim 1, wherein said protective chain is a block copolymer of polyethylene glycol and one of the group of polyamino acids, polysaccharides, polyamidoamines, polyethyleneamines, or polynucleotides.
Claim 15
Dependent Claim
22 words
The composition of claim 1, wherein said protective chain is a copolymer of polyethylene glycol comprising a monoester of a dicarboxylic acid.
Claim 16
Dependent Claim
16 words
The composition of claim 1, wherein said protective chain has a molecular weight of 500-10,000 daltons.
Claim 17
Dependent Claim
12 words
The composition of claim 1, wherein said complexone is a chelating group.
Claim 18
Dependent Claim
38 words
The composition of claim 16, wherein said chelating group is diethylenetriamine-pentaacetic acid, triethylenetetraminehexaacetic acid, ethylenediaminetetraacetic acid, 1,2-diaminocyclo-hexane-N,N,N',N'-tetraacetic acid, N,N'-Di(2-hydroxybenzyl)ethylenediamine, N-(2-hydroxyethyl)ethylenediaminetriacetic acid, nitrilotriacetic acid, ethylene-bis(oxyethylene-nitrilo)tetraacetic acid, 1,4,7,10,-tetraazacyclodo-decane-N,N',N",N'",-tetraacetic acid, 1,4,7,10,-tetraazacyclododecane -N,N',N"-triacetic acid, 1,4,7-tris(carboxymethyl)-10-(2-hydroxy)propyl)-1,4,7,10-te traazocyclodecane, 1,4,7-triazacyclonane-N,N',N"-triacetic acid, or 1,4,8,11-tetraazacyclotetradecane-N,N',N", N'"-tetra-acetic acid.
Claim 19
Dependent Claim
14 words
The composition of claim 1, wherein said complexone is linked to a diagnostic agent.
Claim 20
Dependent Claim
13 words
The composition of claim 18, wherein said diagnostic agent is a contrast agent.
Claim 21
Dependent Claim
13 words
The composition of claim 19, wherein said contrast agent comprises a paramagnetic element.
Claim 22
Dependent Claim
27 words
The composition of claim 20, wherein said paramagnetic element is chosen from the group of transitional metals or lanthanides having atomic numbers 21-29, 42, 44, or 57-71.
Claim 23
Dependent Claim
23 words
The composition of claim 20, wherein said paramagnetic element is gadolinium (III), dysprosium (III), holmium (III), europium (III), iron (III), or manganese (II).
Claim 24
Dependent Claim
17 words
The composition of claim 1, further comprising an alfa-, beta-, or gamma-emitting radionuclide linked to said complexone.
Claim 25
Dependent Claim
29 words
The composition of claim 23, wherein said radionuclide is gallium 67, indium 111, technetium 99m, chromium 51, cobalt 57, molybdenum 99, or a molecule linked to an iodine isotope.
Claim 26
Dependent Claim
13 words
The composition of claim 19, wherein said contrast agent comprises a superparamagnetic element.
Claim 27
Dependent Claim
13 words
The composition of claim 20, wherein said contrast agent further comprises a radionuclide.
Claim 28
Dependent Claim
24 words
The composition of claim 1, wherein said therapeutic agent is a cytostatic, antibiotic, hormonal, analgesic, psychotropic, anti-inflammatory, antiviral, or antifungal drug, or a lymphokine.
Claim 29
Dependent Claim
15 words
The composition of claim 1, further comprising a targeting group linked to said polymeric carrier.
Claim 30
Dependent Claim
22 words
The composition,of claim 28, wherein said targeting group is an antibody, fragment of an antibody, chimeric, antibody, enzyme, lectin, or saccharide ligand.
Claim 31
Dependent Claim
105 words
The composition of claim 1, having the formula: ##STR5## wherein said ##STR6## groups can be linked in any order; wherein k is 100-560; R 1 is (CH 2 ) 4 NHCO(CH 2 ) n COOCH 2 CH 2 A-B-OR 3 , where n is 2-6; A is [OCH 2 CH 2 ] x , where x is 15-220; B is [OCH 2 CH 2 ] x or [OCH(CH 3 )CH 2 ] y , where y+x is 17-220; R 2 is a chelating group; and R 3 is H, (CH 2 ) p CH 3 or (CH 2 ) p COOH, and p is 0-7.
Claim 32
Dependent Claim
23 words
The composition of claim 30, wherein said chelating group is diethylenetriamine pentaacetic acid, 1,4,7,10,-tetraazacyclododecane-N,N',N", N'"-tetraacetic acid, 1,4,7,10,-tetraazacyclododecane-N,N',N",-triacetic acid, ethylene-bis(oxyethylenenitrilo)tetraacetic acid, or ethylenediaminetetraacetic acid.
Claim 33
Dependent Claim
13 words
The composition of claim 18, wherein said diagnostic agent is a fluorine-containing molecule.
References Cited (Backward Citations)
US4647447A
Cited
US4849208A
Cited
US5069216A
Cited
US5141739A
Cited
US5160725A
Cited
US5208324A
Cited
EP0331616A2
Cited
US5213788A
Cited
US5171563A
Cited
US5094848A
Cited
WO1991015753A1
Cited
WO1991018630A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-01-14 | 2000-07-15 | 2001-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-01-14 | 2004-07-15 | 2005-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-01-14 | 2008-07-15 | 2009-01-14 | $7700.00 | Window Closed / Lapsed |