US5602038A
Expired / Lapsed
US
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Method of determining renal clearances
Assignee: PROGRESSION Ltd
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Filing: 1996-01-25
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Granted: 1997-02-11
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Expires: 2016-01-25
Abstract
Abstract In a method of determining creatinine clearance for detecting and monitoring renal dysfunction, spot samples of urine and blood from a person are obtained. Specific gravity or osmolality and creatinine concentration of the urine sample are measured. Creatinine concentration of plasma of the blood sample is also measured. Creatinine clearance is calculated as a function of the measured urine specific gravity or osmolality, the measured urine creatinine concentration and the measured plasma creatinine concentration.
Inventors
- 👤 Michael Kell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 18:24
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/493; G01N33/50; G01N33/70; Y; Y10; Y10T; Y10T436/00; Y10T436/14; Y10T436/145555; Y10T436/147777
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
82 words
A method of determining creatinine clearance for use in detecting and monitoring renal dysfunction comprising the steps of: (a) obtaining spot samples of urine and blood from a person; (b) measuring specific gravity and creatinine concentration of the urine sample; (c) calculating the specific gravity factor; (d) measuring creatinine concentration of plasma of the blood sample; and (e) calculating creatinine clearance as a function of the calculated urine specific gravity factor, the measured urine creatinine concentration and the measured plasma creatinine concentration.
Claim 2
Independent Claim
82 words
A method of determining creatinine clearance for use in detecting and monitoring renal dysfunction comprising the steps of: (a) obtaining spot samples of urine and blood from a person; (b) measuring specific gravity and creatinine concentration of the urine sample; (c) calculating the specific gravity factor; (d) measuring creatinine concentration of plasma of the blood sample; and (e) calculating creatinine clearance as a function of the calculated urine specific gravity factor, the measured urine creatinine concentration and the measured plasma creatinine concentration.
Claim 3
Dependent Claim
60 words
The method of claim 1, wherein step (e) creatinine clearance is calculated in accordance with the equation cl=v'·u·SGF/p where cl is the creatinine clearance, v' is the urine volume production rate for persons with reasonably normal renal functions, u is the measured urine creatinine concentration, SGF is the calculated specific gravity factor, and p is the measured plasma creatinine concentration.
Claim 4
Independent Claim
78 words
A method of determining creatinine clearance for detecting and monitoring renal dysfunction comprising the steps of: (a) obtaining spot samples of urine and blood from a person; (b) measuring osmolality and creatinine concentration of the urine sample; (c) calculating urine osmality factor; (d) measuring creatinine concentration of the plasma of the blood sample; and (e) calculating creatinine clearance as a function of the calculated urine osmolality factor, the measured urine creatinine concentration and the measured plasma creatinine concentration.
Claim 5
Independent Claim
78 words
A method of determining creatinine clearance for detecting and monitoring renal dysfunction comprising the steps of: (a) obtaining spot samples of urine and blood from a person; (b) measuring osmolality and creatinine concentration of the urine sample; (c) calculating urine osmality factor; (d) measuring creatinine concentration of the plasma of the blood sample; and (e) calculating creatinine clearance as a function of the calculated urine osmolality factor, the measured urine creatinine concentration and the measured plasma creatinine concentration.
Claim 6
Dependent Claim
61 words
The method of claim 3 wherein step (e) the creatinine clearance is calculated in accordance with the equation cl=v'·u·UOF/p where cl is the creatinine clearance, v' is the urine volume production rate for persons with reasonably normal renal functions, u is the measured urine creatinine concentration, UOF is the calculated urine osmolality factor, and p is the measured plasma creatinine concentration.
Claim 7
Independent Claim
80 words
A method of determining creatinine clearance for detecting and monitoring renal dysfunction comprising the steps of: (a) obtaining spot samples of urine and blood from a person; (b) measuring the osmolality and creatinine concentration of the urine sample; (c) calculating the urine osmolality factor; (d) measuring the creatinine concentration of serum of the blood sample; and (e) calculating creatinine clearance as a function of the calculated urine osmolality factor, the measured urine creatinine concentration and the measured serum creatinine concentration.
Claim 8
Independent Claim
80 words
A method of determining creatinine clearance for detecting and monitoring renal dysfunction comprising the steps of: (a) obtaining spot samples of urine and blood from a person; (b) measuring the osmolality and creatinine concentration of the urine sample; (c) calculating the urine osmolality factor; (d) measuring the creatinine concentration of serum of the blood sample; and (e) calculating creatinine clearance as a function of the calculated urine osmolality factor, the measured urine creatinine concentration and the measured serum creatinine concentration.
Claim 9
Dependent Claim
60 words
The method of claim 5 wherein step (e) the creatinine clearance is calculated in accordance with the equation cl=v'·u·UOF/p where cl is the creatinine clearance, v' is the urine volume production rate for persons with reasonably normal renal functions, u is the measured urine creatinine concentration, UOF is the urine osmolality factor, and p is the measured serum creatinine concentration.
References Cited (Backward Citations)
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