Patent US2590061A successfully refreshed from Google Patents.
US5628781A
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US
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Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants themselves
Assignee: Thomas Jefferson University
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Filing: 1992-09-29
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Granted: 1997-05-13
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Expires: 2012-09-29
Abstract
Abstract Implant materials having porosity are provided by the present invention. Methods for treating a synthetic or naturally occurring implant, such as a vascular graft, intended for implantation in a human patient are also provided comprising obtaining human microvascular fat tissue, homogenizing the fat tissue to provide a cellular slurry, and applying the cellular slurry onto said implant to provide at least 50% confluence of said cells on the surface and/or within the pores of the implant.
Inventors
- 👤 Stuart K. Williams
- 👤 Bruce E. Jarrell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 14:34
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/36; A61L27/38; A61L27/3804; A61L27/3808; A61L27/3839; A61L27/3843; A61L27/50; A61L27/507; A61L27/56
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
58 words
An implant having a lumen, the implant consisting essentially of implant material having a surface porosity of from about 1 to about 20 microns and a permeability of about 10 ml/min/cm 2 to about 40 ml/min/cm 2 wherein endothelial cells are deposited in pores of about 10 to about 20 microns of the implant material by forced deposition.
Claim 2
Dependent Claim
58 words
An implant having a lumen, the implant consisting essentially of implant material having a surface porosity of from about 1 to about 20 microns and a permeability of about 10 ml/min/cm 2 to about 40 ml/min/cm 2 wherein endothelial cells are deposited in pores of about 10 to about 20 microns of the implant material by forced deposition.
Claim 3
Dependent Claim
23 words
The implant of claim 1 in which the lumenal surface of the implant has porosity of from about 1 to about 4 microns.
Claim 4
Dependent Claim
17 words
The implant of claim 1 wherein the implant has a percent pore coverage of at least 8%.
Claim 5
Dependent Claim
16 words
The implant of claim 3 wherein the percent of pore coverage is from 12% to 16%.
Claim 6
Dependent Claim
15 words
The implant of claim 1 wherein microvascular endothelial cells are deposited on the implant surface.
Claim 7
Dependent Claim
57 words
The implant of claim 5 wherein said endothelial cells are transformed with a gene coding for a therapeutic agent selected from the group consisting of plasminogen activator, soluble CD-4, Factor VIII, Factor IX, yon Willebrand Factor, urokinase, hirudin, interferons, tumor necrosis factor, interleukins, hematopoietic growth factor, antibodies, glucocerebrosidase, ADA, phenylalanine, hydroxylase, human growth hormone, insulin and erythropoietin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-05-12 | 2000-11-11 | 2001-05-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-05-12 | 2004-11-11 | 2005-05-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-05-12 | 2008-11-11 | 2009-05-13 | $7700.00 | Window Closed / Lapsed |