Patent US3479266A successfully refreshed from Google Patents.
US5645583A
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Injectable polyethylene oxide gel implant and method for production
Assignee: University of Miami
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Filing: 1995-06-05
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Granted: 1997-07-08
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Expires: 2015-06-05
Abstract
Abstract A biocompatible polyethylene oxide gel implant and method for production which can be injected into the human body for tissue replacement and augmentation. The implant is prepared by dissolving a sample of essentially pure polyethylene oxide in a saline solution in a sealed canister, removing all free oxygen from the container and replacing it with an inert gas, such as argon, and irradiating the canister with a gamma ray source to simultaneously crosslink the polyethylene oxide while sterilizing it. The gel can then be placed into a syringe and injected into the body.
Inventors
- 👤 Franck L. Villain
- 👤 Jean-Marie A. Parel
- 👤 William Gerald Lee
- 👤 Gabriel Simon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 07:08
CPC Classifications
C; C08; C08J; C08J3/00; C08J3/02; C08J3/03; C08J3/075; A; A61; A61F; A61F2/00; A61F2/0059; A61F2/02; A61F2/14; A61F2/147; A61F9/00; A61F9/007; A61F9/013; A61F9/0133; A61L; A61L27/00; A61L27/14; A61L27/18; C08G; C08G65/00; C08G65/02; C08G65/26; C08G65/30; C08G65/32; C08J3/28; C08L; C08L71/00; C08L71/02; A61B; A61B17/00; A61B17/32; A61B2017/320044; A61F2/12; C08J2371/00; C08J2371/02; Y; Y10; Y10S; Y10S623/00; Y10S623/902; Y10S623/905; Y10S623/906
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
88 words
A method of implanting a biocompatible gel into the cornea of a mammal, comprising the steps of: dissolving a sample of polyethylene oxide in a saline solution; transferring the polyethylene oxide solution to a sealed canister; removing the free oxygen from said canister; replacing the oxygen within said canister with an inert gas; irradiating said canister to crosslink the polyethylene oxide to form a sterile biocompatible gel; inserting said sterile gel into a syringe; and implanting said sterile gel into a cornea to form a space filling implant.
Claim 2
Independent Claim
88 words
A method of implanting a biocompatible gel into the cornea of a mammal, comprising the steps of: dissolving a sample of polyethylene oxide in a saline solution; transferring the polyethylene oxide solution to a sealed canister; removing the free oxygen from said canister; replacing the oxygen within said canister with an inert gas; irradiating said canister to crosslink the polyethylene oxide to form a sterile biocompatible gel; inserting said sterile gel into a syringe; and implanting said sterile gel into a cornea to form a space filling implant.
Claim 3
Dependent Claim
22 words
The method of claim 1, whereas the implanting step causes said sterile gel to crack as it is expelled from said syringe.
Claim 4
Dependent Claim
20 words
The method of claim 2, wherein the polyethylene oxide has a molecular weight of at least 200,000 daltons before cross-linking.
Claim 5
Dependent Claim
33 words
The method of claim 3, wherein the saline solution comprises a Balanced Salt Solution, and said canister is irradiated by a gamma ray source at a dosage of from 2.5 to 25 Mrads.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-07-07 | 2001-01-06 | 2001-07-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-07-07 | 2005-01-06 | 2005-07-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-07-07 | 2009-01-06 | 2009-07-08 | $7700.00 | Window Closed / Lapsed |