US5650116A
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Method of making a medical device from ironically crosslinked polymer
Assignee: Boston Scientific Scimed Inc
•
Filing: 1996-03-18
•
Granted: 1997-07-22
•
Expires: 2016-03-18
Abstract
Abstract The present invention provides a method for making medical devices, especially stents, catheters, cannulas, plugs and constrictors, by treatment of ionically crosslinkable polymer compositions with crosslinking ions.
Inventors
- 👤 Samuel Anthony Thompson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 23:19
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/148; A61L29/00; A61L29/14; A61L29/148; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985; Y10T428/2987
Claims Analysis
Total Claims: 67
Claim 1
Independent Claim
61 words
A method for making a medical device, said method comprising forming an ionically crosslinkable anionic or cationic polymer into a shape suitable for a medical device and crosslinking said shaped ionically crosslinkable polymer by treating it with a crosslinking ion, wherein said medical device comprises at least one member selected from the group consisting of stents, catheters, cannulas, plugs, and constrictors.
Claim 2
Independent Claim
61 words
A method for making a medical device, said method comprising forming an ionically crosslinkable anionic or cationic polymer into a shape suitable for a medical device and crosslinking said shaped ionically crosslinkable polymer by treating it with a crosslinking ion, wherein said medical device comprises at least one member selected from the group consisting of stents, catheters, cannulas, plugs, and constrictors.
Claim 3
Dependent Claim
27 words
The method of claim 1 wherein said ionically crosslinkable polymer comprises at least one member selected from the group consisting of carboxylic, sulfate and amine functionalized polymers.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein said ionically crosslinkable polymer comprises at least one polysaccharide.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein said ionically crosslinkable polymer comprises at least one ionically crosslinkable anionic polymer.
Claim 6
Dependent Claim
18 words
The method of claim 1 wherein said ionically crosslinkable polymer comprises at least one ionically crosslinkable cationic polymer.
Claim 7
Dependent Claim
48 words
The method of claim 4 wherein said ionically crosslinked anionic polymer comprises at least one member selected from the group consisting of polyacrylic acid, polymethacrylic acid, alginic acid, pectinic acid, carboxy methyl cellulose, hyaluronic acid, heparin, carboxymethyl starch, carboxymethyl dextran, heparin sulfate, and chondroitin sulfate, and salts thereof.
Claim 8
Dependent Claim
38 words
The method of claim 5 wherein said ionically crosslinked cationic polymer comprises at least one polymer made from at least one ionically crosslinkable polymer selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine.
Claim 9
Dependent Claim
41 words
The method of claim 4 wherein said ionically crosslinked anionic polymer comprises at least one polymer made from at least one ionically crosslinkable polymer selected from the group consisting of alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid, and salts thereof.
Claim 10
Dependent Claim
14 words
The method of claim 1 wherein said crosslinking ion comprises one or more cations.
Claim 11
Dependent Claim
32 words
The method of claim 9 wherein said one or more cations are selected from the group consisting of calcium, magnesium, barium, strontium, boron, beryllium, aluminum, iron, copper, cobalt, lead, and silver ions.
Claim 12
Dependent Claim
23 words
The method of claim 9 wherein said one or more cations are selected from the group consisting of calcium, iron, and aluminum ions.
Claim 13
Dependent Claim
14 words
The method of claim 10 wherein said one or more cations is calcium ion.
Claim 14
Dependent Claim
14 words
The method of claim 1 wherein said crosslinking ion comprises one or more anions.
Claim 15
Dependent Claim
29 words
The method of claim 13 wherein said crosslinking ion comprises one or more anions selected from the group consisting of phosphate, citrate, borate, succinate, maleate, adipate and oxalate ions.
Claim 16
Dependent Claim
15 words
The method of claim 14 wherein said ionically crosslinked polymer is crosslinked by phosphate ion.
Claim 17
Independent Claim
53 words
A method of modifying the shape of a shaped medical device comprising ionically crosslinked polymer, said method comprising imparting a new shape to the device followed by heat treatment at a temperature above about 40° C. to obtain a device with improved stiffness and resistance to creep, wherein the new shape is retained.
Claim 18
Independent Claim
53 words
A method of modifying the shape of a shaped medical device comprising ionically crosslinked polymer, said method comprising imparting a new shape to the device followed by heat treatment at a temperature above about 40° C. to obtain a device with improved stiffness and resistance to creep, wherein the new shape is retained.
Claim 19
Dependent Claim
19 words
The method of claim 16 wherein said ionically crosslinked polymer is heated at a temperature above about 75° C.
Claim 20
Dependent Claim
19 words
The method of claim 16 wherein said ionically crosslinked polymer is heated at a temperature above about 100° C.
Claim 21
Dependent Claim
19 words
The method of claim 16 wherein said ionically crosslinked polymer is heated at a temperature above about 121° C.
Claim 22
Dependent Claim
35 words
The method of claim 16 wherein said ionically crosslinked polymer comprises at least one polymer made from at least one ionically crosslinkable polymer selected from the group consisting of carboxylic, sulfate and amine functionalized polymers.
Claim 23
Dependent Claim
21 words
The method of claim 16 wherein said ionically crosslinked polymer comprises at least one polymer made from at least one polysaccharide.
Claim 24
Dependent Claim
24 words
The method of claim 16 wherein said ionically crosslinked polymer comprises at least one polymer made from at least one ionically crosslinkable anionic polymer.
Claim 25
Dependent Claim
24 words
The method of claim 16 wherein said ionically crosslinked polymer comprises at least one polymer made from at least one ionically crosslinkable cationic polymer.
Claim 26
Dependent Claim
56 words
The method of claim 22 wherein said ionically crosslinked anionic polymer comprises at least one polymer made from at least one ionically crosslinkable polymer selected from the group consisting of polyacrylic acid, polymethacrylic acid, alginic acid, pectinic acid, carboxy methyl cellulose, hyaluronic acid, heparin, carboxymethyl starch, carboxymethyl dextran, heparin sulfate, and chondroitin sulfate, and salts thereof.
Claim 27
Dependent Claim
38 words
The method of claim 23 wherein said ionically crosslinked cationic polymer comprises at least one polymer made from at least one ionically crosslinkable polymer selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine.
Claim 28
Dependent Claim
41 words
The method of claim 22 wherein said ionically crosslinked anionic polymer comprises at least one polymer made from at least one ionically crosslinkable polymer selected from the group consisting of alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid, and salts thereof.
Claim 29
Dependent Claim
22 words
The method of claim 16 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises one or more cations.
Claim 30
Dependent Claim
32 words
The method of claim 27 wherein said one or more cations are selected from the group consisting of calcium, magnesium, barium, strontium, boron, beryllium, aluminum, iron, copper, cobalt, lead, and silver ions.
Claim 31
Dependent Claim
23 words
The method of claim 27 wherein said one or more cations are selected from the group consisting of calcium, iron, and aluminum ions.
Claim 32
Dependent Claim
14 words
The method of claim 27 wherein said one or more cations is calcium ion.
Claim 33
Dependent Claim
22 words
The method of claim 16 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises one or more anions.
Claim 34
Dependent Claim
27 words
The method of claim 31 wherein said one or more anions are selected from the group consisting of phosphate, citrate, borate, succinate, maleate, adipate and oxalate ions.
Claim 35
Dependent Claim
14 words
The method of claim 32 wherein said one or more anions is phosphate ion.
Claim 36
Independent Claim
70 words
A method of making a tubular medical device comprising introducing an ionically crosslinkable anionic or cationic polymer through a die to form a tube, simultaneously pumping a solution comprising crosslinking ion through said formed tube, and extruding said formed tube from said die into a solution comprising crosslinking ion to crosslink said formed tube, wherein said tubular medical device is selected from the group consisting of stents, catheters and cannulas.
Claim 37
Independent Claim
70 words
A method of making a tubular medical device comprising introducing an ionically crosslinkable anionic or cationic polymer through a die to form a tube, simultaneously pumping a solution comprising crosslinking ion through said formed tube, and extruding said formed tube from said die into a solution comprising crosslinking ion to crosslink said formed tube, wherein said tubular medical device is selected from the group consisting of stents, catheters and cannulas.
Claim 38
Dependent Claim
12 words
The method of claim 34 further comprising heat treating said formed tube.
Claim 39
Dependent Claim
27 words
The method of claim 34 wherein said ionically crosslinkable polymer comprises at least one member selected from the group consisting of carboxylic, sulfate and amine functionalized polymers.
Claim 40
Dependent Claim
15 words
The method of claim 34 wherein said ionically crosslinkable polymer comprises at least one polysaccharide.
Claim 41
Dependent Claim
18 words
The method of claim 34 wherein said ionically crosslinkable polymer comprises at least one ionically crosslinkable anionic polymer.
Claim 42
Dependent Claim
18 words
The method of claim 34 wherein said ionically crosslinkable polymer comprises at least one ionically crosslinkable cationic polymer.
Claim 43
Dependent Claim
48 words
The method of claim 38 wherein said ionically crosslinkable anionic polymer comprises at least one member selected from the group consisting of polyacrylic acid, polymethacrylic acid, alginic acid, pectinic acid, carboxy methyl cellulose, hyaluronic acid, heparin, carboxymethyl starch, carboxymethyl dextran, heparin sulfate, and chondroitin sulfate, and salts thereof.
Claim 44
Dependent Claim
30 words
The method of claim 39 wherein said ionically crosslinkable cationic polymer comprises at least one member selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine.
Claim 45
Dependent Claim
33 words
The method of claim 38 wherein said ionically crosslinkable anionic polymer comprises at least one member selected from the group consisting of alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid, and salts thereof.
Claim 46
Dependent Claim
14 words
The method of claim 34 wherein said crosslinking ion comprises one or more cations.
Claim 47
Dependent Claim
34 words
The method of claim 43 wherein said crosslinking ion comprises one or more cations selected from the group consisting of calcium, magnesium, barium, strontium, boron, beryllium, aluminum, iron, copper, cobalt, lead, and silver ions.
Claim 48
Dependent Claim
23 words
The method of claim 43 wherein said one or more cations are selected from the group consisting of calcium, iron, and aluminum ions.
Claim 49
Dependent Claim
14 words
The method of claim 44 wherein said one or more cations is calcium ion.
Claim 50
Dependent Claim
14 words
The method of claim 34 wherein said crosslinking ion comprises one or more anions.
Claim 51
Dependent Claim
27 words
The method of claim 47 wherein said one or more anions are selected from the group consisting of phosphate, citrate, borate, succinate, maleate, adipate and oxalate ions.
Claim 52
Dependent Claim
14 words
The method of claim 47 wherein said one or more anions is phosphate ion.
Claim 53
Dependent Claim
27 words
The method of claim 6 wherein said ionically crosslinked anionic polymer comprises at least one polymer made from the group consisting of alginic acid and salts thereof.
Claim 54
Dependent Claim
19 words
The method of claim 50 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises barium.
Claim 55
Dependent Claim
19 words
The method of claim 50 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises strontium.
Claim 56
Dependent Claim
19 words
The method of claim 50 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises copper.
Claim 57
Dependent Claim
19 words
The method of claim 50 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises lead.
Claim 58
Dependent Claim
27 words
The method of claim 24 wherein said ionically crosslinked anionic polymer comprises at least one polymer made from the group consisting of alginic acid and salts thereof.
Claim 59
Dependent Claim
19 words
The method of claim 55 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises barium.
Claim 60
Dependent Claim
19 words
The method of claim 55 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises strontium.
Claim 61
Dependent Claim
19 words
The method of claim 55 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises copper.
Claim 62
Dependent Claim
19 words
The method of claim 55 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises lead.
Claim 63
Dependent Claim
27 words
The method of claim 40 wherein said ionically crosslinkable anionic polymer comprises at least one polymer made from the group consisting of alginic acid and salts thereof.
Claim 64
Dependent Claim
11 words
The method of claim 60 wherein said crosslinking ion comprises barium.
Claim 65
Dependent Claim
11 words
The method of claim 60 wherein said crosslinking ion comprises strontium.
Claim 66
Dependent Claim
11 words
The method of claim 60 wherein said crosslinking ion comprises copper.
Claim 67
Dependent Claim
11 words
The method of claim 60 wherein said crosslinking ion comprises lead.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-07-21 | 2001-01-20 | 2001-07-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-07-21 | 2005-01-20 | 2005-07-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-07-21 | 2009-01-20 | 2009-07-22 | $7700.00 | Window Closed / Lapsed |