US5655530A
Expired / Lapsed
US
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Method for non-invasive blood analyte measurement with improved optical interface
Assignee: Rio Grande Medical Technologies Inc
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Filing: 1995-08-09
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Granted: 1997-08-12
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Expires: 2015-08-09
Abstract
Abstract A method for non-invasively measuring the concentration of an analyte, particularly blood analyte in blood. The method utilizes spectrographic techniques in conjunction with an improved optical interface between a sensor probe and a skin surface or tissue surface of the body containing the blood to be analyzed. An index-matching medium is disclosed to improve the interface between the sensor probe and skin surface during spectrographic analysis. In a preferred embodiment, the blood analyte concentration in blood is quantified utilizing a partial squares analysis relative to a model incorporating analysis of plural known blood samples.
Inventors
- 👤 Robert G. Messerschmidt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 04:27
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/14532; A61B2562/00; A61B2562/14; A61B2562/146; A61B5/1495
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
180 words
A non-invasive method for measuring the concentration of a blood analyte in human tissue comprising the steps of: (a) providing an apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths operatively connected to an input element of a sensor element, said apparatus further including an output element within said sensor element operatively connected to a spectrum analyzer; (b) selecting a sample area on a skin surface of an analyte-containing human tissue; (c) providing an index-matching medium and disposing a quantity of said medium between said sensor element and said sample area, wherein said index-matching medium comprises a mixture of perfluorocarbons and chlorofluorocarbons; (d) placing said input element and said output element in contact with said quantity of index-matching medium to couple said sensor element with said analyte-containing tissue through said index-matching medium; and (e) irradiating said analyte-containing tissue through said input element so that there is differential absorption of at least some of said wavelengths and measuring said differential absorption of said wavelengths through said output element connected to said spectrum analyzer.
Claim 2
Dependent Claim
180 words
A non-invasive method for measuring the concentration of a blood analyte in human tissue comprising the steps of: (a) providing an apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths operatively connected to an input element of a sensor element, said apparatus further including an output element within said sensor element operatively connected to a spectrum analyzer; (b) selecting a sample area on a skin surface of an analyte-containing human tissue; (c) providing an index-matching medium and disposing a quantity of said medium between said sensor element and said sample area, wherein said index-matching medium comprises a mixture of perfluorocarbons and chlorofluorocarbons; (d) placing said input element and said output element in contact with said quantity of index-matching medium to couple said sensor element with said analyte-containing tissue through said index-matching medium; and (e) irradiating said analyte-containing tissue through said input element so that there is differential absorption of at least some of said wavelengths and measuring said differential absorption of said wavelengths through said output element connected to said spectrum analyzer.
Claim 3
Dependent Claim
43 words
The method of claim 1, further comprising the step of calculating a concentration of said blood analyte in said analyte-containing tissue with said spectrum analyzer by comparing said differential absorption to a model including differential absorption data on plural known analyte-containing tissue samples.
Claim 4
Dependent Claim
25 words
The method of claim 2, wherein a partial least squares analysis is utilized to compare said differential absorption of said analyte-containing tissue to said model.
Claim 5
Dependent Claim
16 words
The method of claim 1, wherein said input element and said output element include optical lenses.
Claim 6
Dependent Claim
22 words
The method of claim 1, wherein said sample area is a skin surface on an underside of a forearm of a patient.
Claim 7
Dependent Claim
19 words
The method of claim 1, wherein said index-matching medium has a refractive index of about 1.30 to about 1.40.
Claim 8
Dependent Claim
226 words
A non-invasive method for measuring the concentration of a blood analyte in a human tissue comprising the steps of: (a) providing an apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths operatively connected to an input element of a sensor element, said apparatus further including an output element within said sensor element operatively connected to a spectrum analyzer; (b) selecting a sample area on a skin surface of an analyte-containing human tissue; (c) providing an index-matching medium and disposing a first quantity of said medium between said input element and said sample area and a second quantity of index-matching medium between said output element and an opposing surface of said sample area, wherein said index-matching medium comprises a mixture of perfluorocarbons and chlorofluorocarbons; (d) placing said input element in contact with said first quantity of index-matching medium and said output element in contact with said second quantity of index-matching medium to couple said sensor element with said analyte-containing tissue through said first and said second quantity of index-matching medium; and, (e) irradiating said analyte-containing tissue through said input element so that there is differential absorption of at least some of said wavelengths and measuring said differential absorption by transmittance of a portion of said wavelengths through said analyte-containing tissue to said output element connected to said spectrum analyzer.
Claim 9
Dependent Claim
226 words
A non-invasive method for measuring the concentration of a blood analyte in a human tissue comprising the steps of: (a) providing an apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths operatively connected to an input element of a sensor element, said apparatus further including an output element within said sensor element operatively connected to a spectrum analyzer; (b) selecting a sample area on a skin surface of an analyte-containing human tissue; (c) providing an index-matching medium and disposing a first quantity of said medium between said input element and said sample area and a second quantity of index-matching medium between said output element and an opposing surface of said sample area, wherein said index-matching medium comprises a mixture of perfluorocarbons and chlorofluorocarbons; (d) placing said input element in contact with said first quantity of index-matching medium and said output element in contact with said second quantity of index-matching medium to couple said sensor element with said analyte-containing tissue through said first and said second quantity of index-matching medium; and, (e) irradiating said analyte-containing tissue through said input element so that there is differential absorption of at least some of said wavelengths and measuring said differential absorption by transmittance of a portion of said wavelengths through said analyte-containing tissue to said output element connected to said spectrum analyzer.
Claim 10
Dependent Claim
43 words
The method of claim 7, further comprising the step of calculating a concentration of said blood analyte in said analyte-containing tissue with said spectrum analyzer by comparing said differential absorption to a model including differential absorption data on plural known analyte-containing tissue samples.
Claim 11
Dependent Claim
25 words
The method of claim 8, wherein a partial least squares analysis is utilized to compare said differential absorption of said analyte-containing tissue to said model.
Claim 12
Dependent Claim
16 words
The method of claim 7, wherein said input element and said output element include optical lenses.
Claim 13
Dependent Claim
22 words
The method of claim 7, wherein said sample area is a skin surface on an underside of a forearm of a patient.
Claim 14
Dependent Claim
19 words
The method of claim 7, wherein said index-matching medium has a refractive index of about 1.30 to about 1.40.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-08-11 | 2001-02-10 | 2001-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-08-11 | 2005-02-10 | 2005-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-08-11 | 2009-02-10 | 2009-08-12 | $7700.00 | Window Closed / Lapsed |