US5728753A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bioactive composite material for repair of hard and soft tissues
Assignee: University of London
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Filing: 1995-11-09
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Granted: 1998-03-17
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Expires: 2015-11-09
Abstract
Abstract Composites suitable for use as prostheses for attachment to soft tissues, such as cartilage, tendons, skin, tympanic membrane and gingiva, as well as to cancellous or trabecular bone, are based on combination of a polyolefinic binder with certain bioactive glass materials. The composites bond actively with soft tissues and are readily formulated achieve mechanical properties comparable to those of the soft tissue of interest.
Inventors
- 👤 William Bonfield
- 👤 Min Wang
- 👤 Larry L. Hench
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 00:38
CPC Classifications
C; C03; C03C; C03C4/00; C03C4/0007; A; A61; A61K; A61K33/00; A61K33/06; A61K33/42; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/446; C03C1/00; C03C1/006; C03C11/00; C03C12/00; C03C14/00; C08; C08K; C08K3/00; C08K3/18; C08K3/20; C08K3/22; C08L; C08L23/00; C08L23/02; C08L23/04; C08L23/06; Y; Y10; Y10S; Y10S623/00; Y10S623/924
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
110 words
A bioactive composite material comprising a solid-phase homo- or copolyolefin binder with a weight-average molecular weight greater than about 100,000 and less than about 1,000,000 having dispersed therein about 5% to about 50% by volume of particulate bioactive glass material comprised of about 42% to about 52% silicon dioxide, the remainder comprised of oxides of sodium, calcium, and phosphorous and having an average particle size ranging from about 0.5 μm to about 500 μm sufficient to achieve in vivo attachment by in vivo formation of hydroxyapatite from said bioactive glass material, the composite material exhibiting a Young's modulus comparable to a soft tissue measured at human physiological temperature and pressure.
Claim 2
Dependent Claim
110 words
A bioactive composite material comprising a solid-phase homo- or copolyolefin binder with a weight-average molecular weight greater than about 100,000 and less than about 1,000,000 having dispersed therein about 5% to about 50% by volume of particulate bioactive glass material comprised of about 42% to about 52% silicon dioxide, the remainder comprised of oxides of sodium, calcium, and phosphorous and having an average particle size ranging from about 0.5 μm to about 500 μm sufficient to achieve in vivo attachment by in vivo formation of hydroxyapatite from said bioactive glass material, the composite material exhibiting a Young's modulus comparable to a soft tissue measured at human physiological temperature and pressure.
Claim 3
Dependent Claim
29 words
The material of claim 1 wherein the soft tissue is selected from the group consisting of cartilage, tendons, ligaments, skin, tympanic membrane, gingiva, subcutaneous tissue and collagen-based connective tissue.
Claim 4
Dependent Claim
19 words
The material of claim 1 wherein wherein the material is further capable of bonding to cancellous or trabecular bone.
Claim 5
Dependent Claim
26 words
The material of claim 1 wherein the polyolefin comprises polyethylene, polypropylene, polybutylene, or a copolymer of ethylene and at least one of propylene, butylene and hexene.
Claim 6
Dependent Claim
11 words
The material of claim 4 wherein the polyolefin comprises linear polyethylene.
Claim 7
Dependent Claim
15 words
The material of claim 1 wherein the Young's modulus lies in the range 0.5-4.0 GPa.
Claim 8
Dependent Claim
17 words
The material of claim 1 wherein the particulate bioactive glass material ranges in size from 1.5-150 μm.
Claim 9
Dependent Claim
20 words
The material of claim 1 wherein the material also exhibits a tensile strength comparable to that of a soft tissue.
Claim 10
Dependent Claim
20 words
The material of claim 1 wherein the material also exhibits a fracture strain comparable to that of a soft tissue.
Claim 11
Dependent Claim
106 words
A bioactive composite material comprising a mono- or copolyolefin binder with a weight average molecular weight greater than about 100,000 and less than about 1,000,000 having dispersed therein about 5% to about 50% by volume of at least one particulate bioactive glass comprised of about 42% to about 52% silicon dioxide, the remainder comprised of oxides of sodium, calcium, and phosphorous and having an average particle size ranging from about 0.5 μm to about 500 μm sufficient to achieve in vivo attachment by in vivo formation of hydroxyapatite from said particulate bioactive glass when said composite is exposed to in vivo ambient body fluids in vivo.
Claim 12
Dependent Claim
106 words
A bioactive composite material comprising a mono- or copolyolefin binder with a weight average molecular weight greater than about 100,000 and less than about 1,000,000 having dispersed therein about 5% to about 50% by volume of at least one particulate bioactive glass comprised of about 42% to about 52% silicon dioxide, the remainder comprised of oxides of sodium, calcium, and phosphorous and having an average particle size ranging from about 0.5 μm to about 500 μm sufficient to achieve in vivo attachment by in vivo formation of hydroxyapatite from said particulate bioactive glass when said composite is exposed to in vivo ambient body fluids in vivo.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-03-16 | 2001-09-15 | 2002-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-03-16 | 2005-09-15 | 2006-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-03-16 | 2009-09-15 | 2010-03-17 | $7700.00 | Window Closed / Lapsed |