US5756457A
Expired / Lapsed
US
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Neural regeneration using human bone morphogenetic proteins
Assignee: Genetics Institute LLC
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Filing: 1995-05-05
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Granted: 1998-05-26
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Expires: 2015-05-05
Abstract
Abstract Methods and devices are disclosed for inducing growth of neural cells, and repairing neural defects in a mammal. The method comprises administering to said mammal at the site of neural defect, damage or depletion, an effective amount of a bone morphogenetic protein, either in admixture with a pharmaceutically acceptable vehicle, or adsorbed to a suitable matrix. The device comprises bone morphogenetic protein, optionally in combination with other factors, adsorbed on a suitable matrix and contained within an artificial nerve replacement vessel.
Inventors
- 👤 Elizabeth A. Wang
- 👤 Josephine S. D'Alessandro
- 👤 Dean M. Toriumi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 17:52
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1875; A61L; A61L27/00; A61L31/00; A61L31/04; A61L31/043; A61L31/047; A61P; A61P25/00; A61P43/00; A61L2430/00; A61L2430/32
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
56 words
A nerve replacement device comprising an artificial nerve replacement vessel which contains a composition comprising a bone morphogenetic protein in an amount sufficient to promote the growth of astrocyes and a suitable matrix carrier, said bone morphogenetic protein being selected from the group consisting of BMP-2, BMP-4, BMP-5, BMP-6, BMP-7 and heterodimers of BMP-2/6 and BMP-2/7.
Claim 2
Dependent Claim
56 words
A nerve replacement device comprising an artificial nerve replacement vessel which contains a composition comprising a bone morphogenetic protein in an amount sufficient to promote the growth of astrocyes and a suitable matrix carrier, said bone morphogenetic protein being selected from the group consisting of BMP-2, BMP-4, BMP-5, BMP-6, BMP-7 and heterodimers of BMP-2/6 and BMP-2/7.
Claim 3
Dependent Claim
24 words
The device of claim 1, wherein the bone morphogenetic protein is selected from the group consisting of BMP-2, BMP-4, BMP-2/6 heterodimers and BMP-2/7 heterodimers.
Claim 4
Dependent Claim
29 words
The device of claim 1, wherein the matrix comprises a suitable material selected from the group consisting of collagen, fibrin tissue adhesives, laminin, hyalauironic acid and chondroitin sulfate proteoglycans.
Claim 5
Dependent Claim
10 words
The device of claim 3, wherein the matrix comprises collagen.
Claim 6
Dependent Claim
15 words
The device of claim 4, wherein the collagen is in the form of a sponge.
Claim 7
Dependent Claim
15 words
A nerve replacement device according to claim 5, wherein said bone morphogenetic protein is BMP-2.
Claim 8
Dependent Claim
15 words
The device of claim 1, wherein the artificial nerve replacement vessel comprises vented silastic tubing.
Claim 9
Dependent Claim
15 words
A nerve replacement device according to claim 1, wherein said bone morphogenetic protein is BMP-2.
Claim 10
Dependent Claim
24 words
A method of using the nerve replacement device of claim 1, comprising implanting the devide at a site in need of peripheral nerve repair.
Claim 11
Independent Claim
57 words
A method of inducing formation of astrocytes in a suitable cell population which method comprises administering to said cell population an effective amount of a bone morphogenetic protein in admixture with a pharmaceutically acceptable vehicle, said bone morphogenetic protein being selected from the group consisting of BMP-2, BMP-4, BMP-5, BMP-6, BMP-7 and heterodimers of BMP-2/6 and BMP-2/7.
Claim 12
Independent Claim
57 words
A method of inducing formation of astrocytes in a suitable cell population which method comprises administering to said cell population an effective amount of a bone morphogenetic protein in admixture with a pharmaceutically acceptable vehicle, said bone morphogenetic protein being selected from the group consisting of BMP-2, BMP-4, BMP-5, BMP-6, BMP-7 and heterodimers of BMP-2/6 and BMP-2/7.
Claim 13
Dependent Claim
24 words
The method of claim 9, wherein the bone morphogenetic protein is selected from the group consisting of BMP-2, BMP-4, BMP-2/6 heterodimers and BMP-2/7 heterodimers.
Claim 14
Dependent Claim
16 words
The method of claim 10, wherein the bone morphogenetic protein is adsorbed to a suitable matrix.
Claim 15
Dependent Claim
17 words
The method of claim 11, wherein the matrix comprises collagen is in the form of a sponge.
Claim 16
Dependent Claim
12 words
The method of claim 13, wherein said bone morphogenetic protein is BMP-2.
Claim 17
Dependent Claim
16 words
The method of claim 12, wherein the matrix is contained within an artificial nerve replacement vessel.
Claim 18
Dependent Claim
15 words
The method of claim 15, wherein the artificial nerve replacement vessel comprises vented silastic tubing.
Claim 19
Dependent Claim
12 words
The method of claim 10, wherein said bone morphogenetic protein is BMP-2.
References Cited (Backward Citations)
US4868161A
Cited
US4955892A
Cited
US5292802A
Cited
US5308889A
Cited
US5328955A
Cited
US4920962A
Cited
US4963146A
Cited
US5306307A
Cited
WO1994003200A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-05-25 | 2001-11-24 | 2002-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-05-25 | 2005-11-24 | 2006-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-05-25 | 2009-11-24 | 2010-05-26 | $7700.00 | Window Closed / Lapsed |