US5772640A
Expired / Lapsed
US
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Triclosan-containing medical devices
Assignee: Columbia University
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Filing: 1996-01-05
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Granted: 1998-06-30
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Expires: 2016-01-05
Abstract
Abstract The present invention relates to polymeric medical articles contained the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are contained in either hydrophilic or hydrophobic polymers.
Inventors
- 👤 Shanta Modak
- 👤 Lester Sampath
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 17:52
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61L27/00; A61L27/28; A61L27/34; A61L27/50; A61L27/54; A61L29/00; A61L29/08; A61L29/085; A61L29/14; A61L29/16; A61L31/08; A61L31/10; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/20; A61L2300/202; A61L2300/204; A61L2300/206; A61L2300/40; A61L2300/404; A61L2300/45; Y; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/1328; Y10T428/1331; Y10T428/1352
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
65 words
A hydrophilic polymeric medical article which has been impregnated, coated, or impregnated and coated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophilic polymer; (ii) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; and (iii) between 0.5 and 5 percent of triclosan.
Claim 2
Dependent Claim
65 words
A hydrophilic polymeric medical article which has been impregnated, coated, or impregnated and coated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophilic polymer; (ii) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; and (iii) between 0.5 and 5 percent of triclosan.
Claim 3
Dependent Claim
25 words
The medical article of claim 1 which is fabricated from a hydrophilic polymer selected from the group consisting of natural rubber latex and biomedical polyurethane.
Claim 4
Dependent Claim
18 words
The medical article of claim 1 wherein the hydrophilic polymer in the treatment solution is a biomedical polyurethane.
Claim 5
Dependent Claim
18 words
The medical article of claim 2 wherein the hydrophilic polymer in the treatment solution is a biomedical polyurethane.
Claim 6
Dependent Claim
65 words
A hydrophilic polymeric medical article which has been impregnated, coated, or impregnated and coated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophobic polymer (ii) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; and (iii) between 0.5 and 5 percent of triclosan.
Claim 7
Dependent Claim
65 words
A hydrophilic polymeric medical article which has been impregnated, coated, or impregnated and coated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophobic polymer (ii) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; and (iii) between 0.5 and 5 percent of triclosan.
Claim 8
Dependent Claim
10 words
The medical article of claim 5, further comprising silver sulfadiazine.
Claim 9
Dependent Claim
15 words
The medical article of claim 6 wherein the hydrophobic polymer is a biomedical silicone polymer.
Claim 10
Dependent Claim
14 words
The medical article of claim 6 wherein the hydrophobic polymer is a silicone-polyurethane copolymer.
Claim 11
Dependent Claim
10 words
The medical article of claim 5 which is a catheter.
Claim 12
Dependent Claim
10 words
The catheter of claim 9 which is an intravenous catheter.
Claim 13
Dependent Claim
12 words
The catheter of claim 10 which is fabricated from a biomedical polyurethane.
Claim 14
Dependent Claim
17 words
The catheter of claim 11 wherein the hydrophobic polymer in the solution is a biomedical silicone-polyurethane copolymer.
Claim 15
Dependent Claim
25 words
The medical article of claim 5 which is fabricated from a hydrophilic polymer selected from the group consisting of natural rubber latex and biomedical polyurethane.
Claim 16
Dependent Claim
19 words
The medical article of claim 13 wherein the hydrophobic polymer in the treatment solution is a biomedical silicone polymer.
Claim 17
Dependent Claim
18 words
The medical article of claim 13 wherein the hydrophobic polymer in the treatment solution is a silicone-polyurethane copolymer.
Claim 18
Dependent Claim
19 words
The medical article of claim 5 wherein the hydrophobic polymer in the treatment solution is a biomedical silicone polymer.
Claim 19
Dependent Claim
18 words
The medical article of claim 5 wherein the hydrophobic polymer in the treatment solution is a silicone-polyurethane copolymer.
Claim 20
Dependent Claim
65 words
A hydrophobic polymeric medical article which has been impregnated, coated, or impregnated and coated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophobic polymer (ii) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; and (iii) between 0.5 and 5 percent of triclosan.
Claim 21
Dependent Claim
65 words
A hydrophobic polymeric medical article which has been impregnated, coated, or impregnated and coated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophobic polymer (ii) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; and (iii) between 0.5 and 5 percent of triclosan.
Claim 22
Dependent Claim
34 words
The medical article of claim 18 which is fabricated from a hydrophobic polymer selected from the group consisting of polytetrafluoroethylene, Dacron, which is a polyethylene terephthalate polyvinylchloride, biomedical silicone polymer, and silicone polyurethane copolymer.
Claim 23
Dependent Claim
19 words
The medical article of claim 19 wherein the hydrophobic polymer in the treatment solution is a biomedical silicone polymer.
Claim 24
Dependent Claim
18 words
The medical article of claim 19 wherein the hydrophobic polymer in the treatment solution is a silicone-polyurethane copolymer.
Claim 25
Dependent Claim
19 words
The medical article of claim 18 wherein the hydrophobic polymer in the treatment solution is a biomedical silicone polymer.
Claim 26
Dependent Claim
18 words
The medical article of claim 18 wherein the hydrophobic polymer in the treatment solution is a silicone-polyurethane copolymer.
Claim 27
Independent Claim
106 words
A method for rendering a silicone catheter antiinfective, comprising: (1) placing the silicone catheter in an impregnating solution comprising (a) a solvent which causes the catheter to swell; (b) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; (c) between 0.5 and 5 percent of triclosan; and (d) between 1 and 10 percent of a biomedical polymer; (2) soaking the catheter in the impregnating solution for a period of time sufficient to allow the catheter to swell; (3) removing the catheter from the impregnating solution; and (4) drying the catheter.
Claim 28
Independent Claim
106 words
A method for rendering a silicone catheter antiinfective, comprising: (1) placing the silicone catheter in an impregnating solution comprising (a) a solvent which causes the catheter to swell; (b) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; (c) between 0.5 and 5 percent of triclosan; and (d) between 1 and 10 percent of a biomedical polymer; (2) soaking the catheter in the impregnating solution for a period of time sufficient to allow the catheter to swell; (3) removing the catheter from the impregnating solution; and (4) drying the catheter.
Claim 29
Dependent Claim
14 words
The method of claim 24, wherein the biomedical polymer is a biomedical silicone polymer.
Claim 30
Dependent Claim
28 words
The method of claim 24, further comprising the step of dipping the catheter, after drying according to step (4), into a second coating solution comprising a biomedical polymer.
Claim 31
Dependent Claim
25 words
The method according to claim 26, wherein the biomedical polymer in both the impregnating solution and the second coating solution is a biomedical silicone polymer.
Claim 32
Dependent Claim
65 words
A hydrophobic polymeric medical article which has been impregnated, coated, or impregnated and coated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophilic polymer; (ii) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; and (iii) between 0.5 and 5 percent of triclosan.
Claim 33
Dependent Claim
65 words
A hydrophobic polymeric medical article which has been impregnated, coated, or impregnated and coated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophilic polymer; (ii) between 1 and 5 percent of an antiinfective agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and a chlorhexidine derivative; and (iii) between 0.5 and 5 percent of triclosan.
Claim 34
Dependent Claim
34 words
The medical article of claim 28 which is fabricated from a hydrophobic polymer selected from the group consisting of polytetrafluoroethylene, Dacron, which is a polyethylene terephthalate polyvinylchloride, biomedical silicone polymer, and silicone polyurethane copolymer.
Claim 35
Dependent Claim
14 words
The medical article of claim 28 wherein the hydrophilic polymer is a biomedical polyurethane.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-06-29 | 2001-12-29 | 2002-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-06-29 | 2005-12-29 | 2006-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-06-29 | 2009-12-29 | 2010-06-30 | $7700.00 | Window Closed / Lapsed |