US5777060A
Expired / Lapsed
US
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Silicon-containing biocompatible membranes
Assignee: Medtronic Minimed Inc
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Filing: 1996-09-26
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Granted: 1998-07-07
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Expires: 2016-09-26
Abstract
Abstract Biocompatible membranes for use with biosensors are provided. The membranes are polymers which can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer, (c) a siloxane polymer having functional groups at the chain termini, and optionally, (d) a chain extender.
Inventors
- 👤 William Peter Van Antwerp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 03:42
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14865; A61B5/41; A61B5/411; C; C08; C08G; C08G18/00; C08G18/06; C08G18/28; C08G18/40; C08G18/48; C08G18/4833; C08G18/61; C08G18/65; C08G18/66; C08G18/6666; C08G18/667; C08G18/6674; C08G77/00; C08G77/42; C08G77/452; C08G77/458; C08J; C08J5/00; C08J5/20; C08J5/22; C08J5/2287; C12; C12Q; C12Q1/00; C12Q1/001; C12Q1/002; C12Q1/005; C12Q1/006; A61B5/14532; C08J2383/00; C08J2383/02
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
105 words
A biocompatible membrane formed from a reaction mixture of: (a) a diisocyanate, said diisocyanate comprising about 50 mol % of the reactants in said mixture; (b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof; (c) a siloxane polymer having functional groups at the chain termini, said membrane having a glucose diffusion coefficient of from about 1×10 -9 cm 2 /sec to about 200×10 -9 cm 2 /sec, a water pickup of at least 25% and a ratio of D oxygen /D glucose of from about 5 to about 200.
Claim 2
Dependent Claim
105 words
A biocompatible membrane formed from a reaction mixture of: (a) a diisocyanate, said diisocyanate comprising about 50 mol % of the reactants in said mixture; (b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof; (c) a siloxane polymer having functional groups at the chain termini, said membrane having a glucose diffusion coefficient of from about 1×10 -9 cm 2 /sec to about 200×10 -9 cm 2 /sec, a water pickup of at least 25% and a ratio of D oxygen /D glucose of from about 5 to about 200.
Claim 3
Dependent Claim
25 words
A biocompatible membrane in accordance with claim 1, wherein said functional groups are members selected from the group consisting of amino, hydroxyl and carboxylic acid.
Claim 4
Dependent Claim
28 words
A biocompatible membrane in accordance with claim 1, wherein said hydrophilic polymer is a poly(ethylene)glycol selected from the group consisting of PEG 200, PEG 400 and PEG 600.
Claim 5
Dependent Claim
27 words
A biocompatible membrane in accordance with claim 1, wherein said diisocyanate is a member selected from the group consisting of isophorone diisocyanate, 1,6-hexamethylene diisocyanate and 4,4'-methylenebis(cyclohexyl isocyanate).
Claim 6
Dependent Claim
18 words
A biocompatible membrane in accordance with claim 1, wherein said reaction mixture further comprises (d) a chain extender.
Claim 7
Dependent Claim
30 words
A biocompatible membrane in accordance with claim 5, wherein said chain extender is selected from the group consisting of an alkylene diol, an alkylene diamine, an aminoalkanol and combinations thereof.
Claim 8
Dependent Claim
74 words
A biocompatible membrane in accordance with claim 1, wherein said diisocyanate is 1,6-hexamethylene diisocyanate, said hydrophilic polymer is selected from the group consisting of PEG 400 and PEG 600 and is present in an amount of about 17 to about 32 mol %, and said siloxane polymer is aminopropyl polysiloxane having a molecular weight of about 2000 to about 4000 and is present in an amount of about 17 to about 32 mol %.
Claim 9
Dependent Claim
22 words
An implantable biosensor for measuring the reaction of an analyte and oxygen, said biosensor having a biocompatible membrane according to claim 1.
Claim 10
Dependent Claim
13 words
An implantable biosensor in accordance with claim 8, wherein the analyte comprises glucose.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-07-06 | 2002-01-05 | 2002-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-07-06 | 2006-01-05 | 2006-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-07-06 | 2010-01-05 | 2010-07-07 | $7700.00 | Window Closed / Lapsed |