US5787900A
Expired / Lapsed
US
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Method for loading and reloading a therapeutical device in a vascularized implantable containment apparatus
Assignee: W.L. Gore and Associates Inc
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Filing: 1996-10-11
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Granted: 1998-08-04
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Expires: 2016-10-11
Abstract
Abstract This invention relates generally to a method of loading and reloading a therapeutical device in a vascularized implantable containment apparatus made of selectively permeable material. Suitable therapeutical devices for use in the present invention include devices such as drug delivery devices, cell encapsulation devices, or gene therapy devices. A therapeutical device can be easily placed and replaced in a vascularized apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
Inventors
- 👤 Mark D. Butler
- 👤 Stanley L. Mish
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 12:13
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/022
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
219 words
A method of loading and reloading a therapeutical device in a vascularized containment apparatus which comprises: providing an implantable containment apparatus in the form of a chamber comprised of a material having an exterior surface, an interior surface defining a luminal space, and at least one access means through which at least one therapeutical device is insertable into the luminal space of the chamber, wherein the material is impervious to cellular ingrowth across the interior surface of the chamber, wherein therapeutic substances can diffuse across the thickness of the chamber between a therapeutical device contained therein and tissues of a recipient, wherein the therapeutical device is removable from the chamber through the access means of the chamber; implanting the implantable containment apparatus in a recipient; allowing cells from the recipient to ingrow the material; opening the access means of the implantable containment apparatus to access the luminal space of the chamber; placing a therapeutical device in the luminal space of the chamber through the access means; closing the access means of the implantable containment apparatus to contain the therapeutical device within the luminal space of the apparatus; removing the therapeutical device from the luminal space of the implantable containment apparatus through the access means; and reloading the containment apparatus with a therapeutical device through the access means as desired.
Claim 2
Independent Claim
219 words
A method of loading and reloading a therapeutical device in a vascularized containment apparatus which comprises: providing an implantable containment apparatus in the form of a chamber comprised of a material having an exterior surface, an interior surface defining a luminal space, and at least one access means through which at least one therapeutical device is insertable into the luminal space of the chamber, wherein the material is impervious to cellular ingrowth across the interior surface of the chamber, wherein therapeutic substances can diffuse across the thickness of the chamber between a therapeutical device contained therein and tissues of a recipient, wherein the therapeutical device is removable from the chamber through the access means of the chamber; implanting the implantable containment apparatus in a recipient; allowing cells from the recipient to ingrow the material; opening the access means of the implantable containment apparatus to access the luminal space of the chamber; placing a therapeutical device in the luminal space of the chamber through the access means; closing the access means of the implantable containment apparatus to contain the therapeutical device within the luminal space of the apparatus; removing the therapeutical device from the luminal space of the implantable containment apparatus through the access means; and reloading the containment apparatus with a therapeutical device through the access means as desired.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein the material comprises porous expanded polytetrafluoroethylene.
Claim 4
Dependent Claim
17 words
The method of claim 2 wherein the porous expanded polytetrafluoroethylene is in the form of a laminate.
Claim 5
Dependent Claim
32 words
The method of claim 3 wherein the laminate comprises at least two layers of porous expanded polytetrafluoroethylene and wherein at least one layer of porous expanded polytetrafluoroethylene is impervious to cellular ingrowth.
Claim 6
Dependent Claim
18 words
The method of claim 1 wherein the material is rendered impervious to cellular ingrowth with a hydrogel material.
Claim 7
Dependent Claim
14 words
The method of claim 1 wherein the therapeutical device is a cell encapsulation device.
Claim 8
Dependent Claim
14 words
The method of claim 1 wherein the therapeutical device is a drug delivery device.
Claim 9
Dependent Claim
14 words
The method of claim 1 wherein the therapeutical device is a gene therapy device.
Claim 10
Dependent Claim
19 words
The method of claim 1 wherein the luminal space of the containment apparatus is held open with a stent.
Claim 11
Dependent Claim
20 words
The method of claim 1 wherein the cells from the recipient comprise vascular endothelial cells in the form of capillaries.
Claim 12
Independent Claim
200 words
A method of loading and reloading a therapeutical device in a vascularized implantable containment apparatus which comprises: providing an implantable containment apparatus in the form of a chamber comprised of a material having an exterior surface, an interior surface defining a luminal space, and at least one access means through which at least one therapeutical device is insertable into the luminal space of the chamber, wherein the material is impervious to cellular ingrowth across the interior surface of the chamber, wherein therapeutic substances can diffuse across the thickness of the chamber between a therapeutical device contained therein and tissues of a recipient, wherein the therapeutical device is removable from the chamber through the access means of the chamber; implanting the implantable containment apparatus in a recipient; inducing cells from a recipient to ingrow the material; opening the access means of the implantable containment apparatus to access the luminal space of the tube; and placing a therapeutical device in the luminal space of the chamber through the access means; removing the therapeutical device from the luminal space of the implantable containment apparatus through the access means; and reloading the containment apparatus with a therapeutical device through the access means as desired.
Claim 13
Independent Claim
200 words
A method of loading and reloading a therapeutical device in a vascularized implantable containment apparatus which comprises: providing an implantable containment apparatus in the form of a chamber comprised of a material having an exterior surface, an interior surface defining a luminal space, and at least one access means through which at least one therapeutical device is insertable into the luminal space of the chamber, wherein the material is impervious to cellular ingrowth across the interior surface of the chamber, wherein therapeutic substances can diffuse across the thickness of the chamber between a therapeutical device contained therein and tissues of a recipient, wherein the therapeutical device is removable from the chamber through the access means of the chamber; implanting the implantable containment apparatus in a recipient; inducing cells from a recipient to ingrow the material; opening the access means of the implantable containment apparatus to access the luminal space of the tube; and placing a therapeutical device in the luminal space of the chamber through the access means; removing the therapeutical device from the luminal space of the implantable containment apparatus through the access means; and reloading the containment apparatus with a therapeutical device through the access means as desired.
Claim 14
Dependent Claim
12 words
The method of claim 11 wherein the material comprises porous expanded polytetrafluoroethylene.
Claim 15
Dependent Claim
17 words
The method of claim 12 wherein the porous expanded polytetrafluoroethylene is in the form of a laminate.
Claim 16
Dependent Claim
32 words
The method of claim 13 wherein the laminate comprises at least two layers of porous expanded polytetrafluoroethylene and wherein at least one layer of porous expanded polytetrafluoroethylene is impervious to cellular ingrowth.
Claim 17
Dependent Claim
18 words
The method of claim 11 wherein the material is rendered impervious to cellular ingrowth with a hydrogel material.
Claim 18
Dependent Claim
14 words
The method of claim 11 wherein the therapeutical device is a cell encapsulation device.
Claim 19
Dependent Claim
14 words
The method of claim 11 wherein the therapeutical device is a drug delivery device.
Claim 20
Dependent Claim
14 words
The method of claim 11 wherein the therapeutical device is a gene therapy device.
Claim 21
Dependent Claim
20 words
The method of claim 11 wherein cells from a recipient are induced to ingrow the material with a biological factor.
Claim 22
Dependent Claim
43 words
The method of claim 19 wherein the biological factor is selected from the group consisting of protein cytokines, peptide cytokines, peptides with the amino acid sequence gly-his-lys or their palindromes, polysaccharides, including heparin, angiogenesis stimulating lipids, including oleic acid, and metals, including copper.
Claim 23
Dependent Claim
21 words
The method of claim 11 wherein cells from the recipient are induced to ingrow the material under local conditions of hypoxia.
Claim 24
Dependent Claim
19 words
The method of claim 11 wherein the luminal space of the containment apparatus is held open with a stent.
Claim 25
Dependent Claim
20 words
The method of claim 11 wherein the cells from the recipient comprise vascular endothelial cells in the form of capillaries.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-08-03 | 2002-02-02 | 2002-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-08-03 | 2006-02-02 | 2006-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-08-03 | 2010-02-02 | 2010-08-04 | $7700.00 | Window Closed / Lapsed |