US5817017A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medical devices and materials having enhanced magnetic images visibility
Assignee: Pharmacyclics LLC
•
Filing: 1994-04-12
•
Granted: 1998-10-06
•
Expires: 2014-04-12
Abstract
Abstract PCT No. PCT/US94/04011 Sec. 371 Date May 24, 1995 Sec. 102(e) Date May 24, 1995 PCT Filed Apr. 12, 1994 PCT Pub. No. WO94/23782 PCT Pub. Date Oct. 27, 1994Catheters and other medical devices include a non-metallic member having paramagnetic ionic particles fixedly incorporated therethrough in order to provide enhanced detectability when viewed by magnetic imaging regardless of the orientation of the non-metallic member in the magnetic field. Catheters are usually formed from polymeric tubing, and the paramagnetic ionic particles are usually formed from paramagnetic ions incorporated with water or other proton-donating fluid into carrier particles, such as zeolites, molecular sieves, clays, synthetic ion exchange resins, and microcapsules. Catheters and other medical devices include a non-metallic member having small iron and/or superparamagnetic particles fixedly incorporated therethrough or thereover in order to provide enhanced detectability when viewed by magnetic imaging. Catheters are usually formed from polymeric tubing, and the iron and/or superparamagnetic particles at or near the surface of the catheter interact with the water protons of the surrounding patient's body to provide image enhancement regardless of the orientation of the polymeric or other non-metallic material in the magnetic field.
Inventors
- 👤 Stuart W. Young
- 👤 Richard A. Miller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 08:25
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/01; A61M25/0105; A61M25/0108; A61M25/0127; A61B; A61B90/00; A61B90/39; A61B2090/3954
Claims Analysis
Total Claims: 77
Claim 1
Independent Claim
95 words
An article for use in internal medical procedures, said article comprising a flexible non-metallic member composed of an organic polymer having paramagnetic ionic particles dispersed directly in a material matrix thereof at a concentration effective to enhance detectability of at least a portion of the article when viewed by magnetic imaging when the article is present in an aqueous environment, which enhancement is irrespective of the orientation of the article in the magnetic field, wherein the concentration of paramagnetic ionic particles in the material matrix is in the range from 0.1% to 20% by weight.
Claim 2
Dependent Claim
95 words
An article for use in internal medical procedures, said article comprising a flexible non-metallic member composed of an organic polymer having paramagnetic ionic particles dispersed directly in a material matrix thereof at a concentration effective to enhance detectability of at least a portion of the article when viewed by magnetic imaging when the article is present in an aqueous environment, which enhancement is irrespective of the orientation of the article in the magnetic field, wherein the concentration of paramagnetic ionic particles in the material matrix is in the range from 0.1% to 20% by weight.
Claim 3
Dependent Claim
15 words
An article as in claim 1, wherein the elongate flexible member is a tubular catheter.
Claim 4
Dependent Claim
77 words
An article as in claim 1, wherein the article is a catheter having an enhanced magnetic image, wherein, the non-metallic member is a tubular member having a proximal end, a distal end, and at least one lumen extending therethrough and being composed of an organic polymer; and the paramagnetic ionic particles are fixedly incorporated in selected portions of the tubular member at a concentration effective to enhance detectability of said selected portion when viewed by magnetic imaging.
Claim 5
Dependent Claim
21 words
An article as in claim 1, 2, or 3, wherein the paramagnetic ionic particles are incorporated uniformly throughout the non-metallic member.
Claim 6
Dependent Claim
21 words
An article as in claim 1, 2, or 3, wherein the paramagnetic ionic particles are incorporated non-uniformly within the non-metallic member.
Claim 7
Dependent Claim
30 words
An article as in claim 3, wherein the paramagnetic ionic particles are incorporated substantially uniformly throughout the tubular member, whereby the entire catheter will have an enhanced magnetic resonance image.
Claim 8
Dependent Claim
34 words
An article as in claim 3, wherein the paramagnetic ionic particles are incorporated in a preselected pattern in the tubular member, whereby only portions of the catheter will have an enhanced magnetic resonance image.
Claim 9
Dependent Claim
21 words
An article as in claim 7, wherein the preselected pattern includes one or more axial bands formed in the tubular member.
Claim 10
Dependent Claim
26 words
An article as in claim 1 or 3, wherein the paramagnetic ionic particles comprise paramagnetic metal ions entrapped in a carrier particle with a proton-donating fluid.
Claim 11
Dependent Claim
26 words
An article as in claim 9, wherein the entrapped ions are selected from the group consisting of elements having atomic numbers 21-29, 42, 44, and 58-70.
Claim 12
Dependent Claim
26 words
An article as in claim 9, wherein the proton-donating fluid is water, an alcohol, a glycerol, a sulfonated detergent, an ether, an amine, or a imidazole.
Claim 13
Dependent Claim
27 words
An article as in claim 9, wherein the carrier particle is a natural or synthetic zeolite, a molecular sieve, a clay, or a synthetic ion exchange resin.
Claim 14
Dependent Claim
29 words
An article as in claim 9, wherein the entrapped ions are Gd +3 , the proton-donating fluid is water, and the ion exchange resin is a type Y zeolite.
Claim 15
Dependent Claim
18 words
An article as in claim 1 or 3, wherein the non-metallic member is substantially free from ferromagnetic materials.
Claim 16
Dependent Claim
16 words
An article as in claim 1 or 3, wherein the non-metallic member further includes radiopaque material.
Claim 17
Independent Claim
83 words
A method for imaging a catheter within a patient's body, said method comprising: introducing to the patient's body a catheter comprising a non-metallic member having paramagnetic ionic particles dispersed directly in a material matrix thereof at a concentration in the material matrix in the range from 0.1% to 20% by weight; and imaging the body using a magnetic imaging device, whereby the catheter will produce an image which will have enhanced detectability irrespective of the orientation of the catheter to the magnetic field.
Claim 18
Independent Claim
83 words
A method for imaging a catheter within a patient's body, said method comprising: introducing to the patient's body a catheter comprising a non-metallic member having paramagnetic ionic particles dispersed directly in a material matrix thereof at a concentration in the material matrix in the range from 0.1% to 20% by weight; and imaging the body using a magnetic imaging device, whereby the catheter will produce an image which will have enhanced detectability irrespective of the orientation of the catheter to the magnetic field.
Claim 19
Dependent Claim
35 words
A method as in claim 16, wherein the non-metallic member is composed of an organic polymer and the paramagnetic ionic particles comprise paramagnetic metal ions entrapped together with a proton-donating fluid in a carrier particle.
Claim 20
Dependent Claim
12 words
A method as in claim 17, wherein the proton-donating fluid is water.
Claim 21
Dependent Claim
15 words
A method as in claim 17, wherein the carrier particle is an ion exchange resin.
Claim 22
Dependent Claim
15 words
A method as in claim 18, wherein the carrier particle is an ion exchange resin.
Claim 23
Dependent Claim
71 words
An article for use in internal medical procedures, said article comprising a non-metallic member having paramagnetic ions entrapped in carrier particles with a proton-donating fluid fixedly incorporated therein at a concentration effective to enhance detectability of at least a portion of the article when viewed by magnetic imaging when the article is present in an aqueous environment, which enhancement is irrespective of the orientation of the article in the magnetic field.
Claim 24
Dependent Claim
71 words
An article for use in internal medical procedures, said article comprising a non-metallic member having paramagnetic ions entrapped in carrier particles with a proton-donating fluid fixedly incorporated therein at a concentration effective to enhance detectability of at least a portion of the article when viewed by magnetic imaging when the article is present in an aqueous environment, which enhancement is irrespective of the orientation of the article in the magnetic field.
Claim 25
Dependent Claim
15 words
An article as in claim 21, wherein the non-metallic member is an elongate flexible member.
Claim 26
Dependent Claim
17 words
An article as in claim 22, wherein the elongate flexible member is composed of an organic polymer.
Claim 27
Dependent Claim
15 words
An article as in claim 23, wherein the elongate flexible member is a tubular catheter.
Claim 28
Dependent Claim
75 words
An article as in claim 21, wherein the article is a catheter having an enhanced magnetic image, wherein, the non-metallic member is a tubular member having a proximal end, a distal end, and at least one lumen extending therethrough and being composed of an organic polymer; and the particles are fixedly incorporated in selected portions of the tubular member at a concentration effective to enhance detectability of said selected portion when viewed by magnetic imaging.
Claim 29
Dependent Claim
21 words
An article as in claim 21, 22, 23, 24, or 25, wherein the particles are incorporated uniformly throughout the non-metallic member.
Claim 30
Dependent Claim
21 words
An article as in claim 21, 22, 23, 24, or 25, wherein the particles are incorporated non-uniformly within the non-metallic member.
Claim 31
Dependent Claim
28 words
An article as in claim 25, wherein the particles are incorporated substantially uniformly throughout the tubular member, whereby the entire catheter will have an enhanced magnetic resonance image.
Claim 32
Dependent Claim
32 words
An article as in claim 25, wherein the particles are incorporated in a preselected pattern in the tubular member, whereby only portions of the catheter will have an enhanced magnetic resonance image.
Claim 33
Dependent Claim
21 words
An article as in claim 29, wherein the preselected pattern includes one or more axial bands formed in the tubular member.
Claim 34
Dependent Claim
26 words
An article as in claim 21, wherein the entrapped ions are selected form the group consisting of elements having atomic numbers 21-29, 42, 44, and 58-70.
Claim 35
Dependent Claim
26 words
An article as in claim 21, wherein the proton-donating fluid is water, an alcohol, a glycerol, a sulfonated detergent, an ether, an amine, or a imidazole.
Claim 36
Dependent Claim
27 words
An article as in claim 21, wherein the carrier particle is a natural or synthetic zeolite, a molecular sieve, a clay, or a synthetic ion exchange resin.
Claim 37
Dependent Claim
29 words
An article as in claim 21, wherein the entrapped ions are Gd +3 , the proton-donating fluid is water, and the ion exchange resin is a type Y zeolite.
Claim 38
Dependent Claim
18 words
An article as in claim 21 or 25, wherein the non-metallic member is substantially free from ferromagnetic materials.
Claim 39
Dependent Claim
16 words
An article as in claim 21 or 25, wherein the non-metallic member further includes radiopaque material.
Claim 40
Dependent Claim
25 words
An article as in claim 21 or 25, wherein the concentration of paramagnetic ionic particles is in the range from 0.1% to 20% by weight.
Claim 41
Independent Claim
92 words
A method for imaging an article within a patient's body, said method comprising: introducing to the patient's body an article comprising a non-metallic member having paramagnetic ionic particles fixedly incorporated therein wherein the non-metallic member is composed of an organic polymer and the paramagnetic ionic particles comprise paramagnetic metal ions entrapped together with a proton-donating fluid in a carrier particle; and imaging the body using a magnetic imaging device, whereby the article will produce an image which will have enhanced detectability irrespective of the orientation of the article to the magnetic field.
Claim 42
Independent Claim
92 words
A method for imaging an article within a patient's body, said method comprising: introducing to the patient's body an article comprising a non-metallic member having paramagnetic ionic particles fixedly incorporated therein wherein the non-metallic member is composed of an organic polymer and the paramagnetic ionic particles comprise paramagnetic metal ions entrapped together with a proton-donating fluid in a carrier particle; and imaging the body using a magnetic imaging device, whereby the article will produce an image which will have enhanced detectability irrespective of the orientation of the article to the magnetic field.
Claim 43
Dependent Claim
12 words
A method as in claim 38, wherein the article comprises a catheter.
Claim 44
Dependent Claim
12 words
A method as in claim 39, wherein the article comprises an implant.
Claim 45
Dependent Claim
12 words
A method as in claim 38, wherein the proton-donating fluid is water.
Claim 46
Dependent Claim
15 words
A method as in claim 38, wherein the carrier particle is an ion exchange resin.
Claim 47
Dependent Claim
15 words
A method as in claim 38, wherein the carrier particle is an ion exchange resin.
Claim 48
Dependent Claim
102 words
An article for use in internal medical procedures, said article comprising a tubular member composed of an organic polymer having paramagnetic ions extruded therein at a concentration effective to enhance detectability of at least a portion of the article when viewed by magnetic imaging when the article is present in an aqueous environment, which enhancement is irrespective of the orientation of the article in the magnetic field, wherein the paramagnetic ions are entrapped in a carrier particle with a proton-donating fluid elected from the group consisting of water, an alcohol, a glycerol, a sulfonated detergent, an ether, an amine, or a imidazole.
Claim 49
Dependent Claim
102 words
An article for use in internal medical procedures, said article comprising a tubular member composed of an organic polymer having paramagnetic ions extruded therein at a concentration effective to enhance detectability of at least a portion of the article when viewed by magnetic imaging when the article is present in an aqueous environment, which enhancement is irrespective of the orientation of the article in the magnetic field, wherein the paramagnetic ions are entrapped in a carrier particle with a proton-donating fluid elected from the group consisting of water, an alcohol, a glycerol, a sulfonated detergent, an ether, an amine, or a imidazole.
Claim 50
Dependent Claim
29 words
An article as in claim 44, wherein the paramagnetic ions are incorporated substantially uniformly throughout the tubular member, whereby the entire catheter will have an enhanced magnetic resonance image.
Claim 51
Dependent Claim
33 words
An article as in claim 44, wherein the paramagnetic ions are incorporated in a preselected pattern in the tubular member, whereby only portions of the catheter will have an enhanced magnetic resonance image.
Claim 52
Dependent Claim
21 words
An article as in claim 46, wherein the preselected pattern includes one or more axial bands formed in the tubular member.
Claim 53
Dependent Claim
27 words
An article as in claim 44, wherein the extruded paramagnetic ions are selected form the group consisting of elements having atomic numbers 21-29, 42, 44, and 58-70.
Claim 54
Dependent Claim
27 words
An article as in claim 44, wherein the carrier particle is a natural or synthetic zeolite, a molecular sieve, a clay, or a synthetic ion exchange resin.
Claim 55
Dependent Claim
29 words
An article as in claim 49, wherein the entrapped ions are Gd +3 , the proton-donating fluid is water, and the ion exchange resin is a type Y zeolite.
Claim 56
Dependent Claim
16 words
An article as in claim 49, wherein the tubular member is substantially free from ferromagnetic materials.
Claim 57
Dependent Claim
14 words
An article as in claim 44, wherein the tubular member further includes radiopaque material.
Claim 58
Dependent Claim
22 words
An article as in claim 44, wherein the concentration of paramagnetic ions is in the range from 0.1% to 20% by weight.
Claim 59
Independent Claim
101 words
A method for imaging an article within a patient's body, said method comprising: introducing to the patient's body an article comprising a tubular body composed of an organic polymer having paramagnetic ions extruded therein; and imaging the body using a magnetic imaging device, whereby the article will produce an image which will have enhanced detectability irrespective of the orientation of the article to the magnetic field, wherein the paramagnetic ions are entrapped in a carrier particle with a proton-donating fluid elected from the group consisting of water, an alcohol, a glycerol, a sulfonated detergent, an ether, an amine, or a imidazole.
Claim 60
Independent Claim
101 words
A method for imaging an article within a patient's body, said method comprising: introducing to the patient's body an article comprising a tubular body composed of an organic polymer having paramagnetic ions extruded therein; and imaging the body using a magnetic imaging device, whereby the article will produce an image which will have enhanced detectability irrespective of the orientation of the article to the magnetic field, wherein the paramagnetic ions are entrapped in a carrier particle with a proton-donating fluid elected from the group consisting of water, an alcohol, a glycerol, a sulfonated detergent, an ether, an amine, or a imidazole.
Claim 61
Dependent Claim
12 words
A method as in claim 54, wherein the article comprises a catheter.
Claim 62
Dependent Claim
27 words
A method as in claim 54, wherein the carrier particle is a natural or synthetic zeolite, a molecular sieve, a clay, or a synthetic ion exchange resin.
Claim 63
Dependent Claim
29 words
A method as in claim 56, wherein the entrapped ions are Gd +3 , the proton-donating fluid is water, and the ion exchange resin is a type Y zeolite.
Claim 64
Dependent Claim
16 words
A method as in claim 56, wherein the tubular member is substantially free from ferromagnetic materials.
Claim 65
Independent Claim
83 words
A method for imaging an implant within a patient's body, said method comprising: introducing to the patient's body an implant comprising a non-metallic member having paramagnetic ionic particles dispersed directly in a material matrix thereof at a concentration in the material matrix in the range from 0.1% to 20% by weight; and imaging the body using a magnetic imaging device, whereby the implant will produce an image which will have enhanced detectability irrespective of the orientation of the implant to the magnetic field.
Claim 66
Independent Claim
83 words
A method for imaging an implant within a patient's body, said method comprising: introducing to the patient's body an implant comprising a non-metallic member having paramagnetic ionic particles dispersed directly in a material matrix thereof at a concentration in the material matrix in the range from 0.1% to 20% by weight; and imaging the body using a magnetic imaging device, whereby the implant will produce an image which will have enhanced detectability irrespective of the orientation of the implant to the magnetic field.
Claim 67
Dependent Claim
35 words
A method as in claim 59, wherein the non-metallic member is composed of an organic polymer and the paramagnetic ionic particles comprise paramagnetic metal ions entrapped together with a proton-donating fluid in a carrier particle.
Claim 68
Dependent Claim
12 words
A method as in claim 60, wherein the proton-donating fluid is water.
Claim 69
Dependent Claim
15 words
A method as in claim 60 wherein the carrier particle is an ion exchange resin.
Claim 70
Dependent Claim
15 words
A method as in claim 60, wherein the carrier particle is an ion exchange resin.
Claim 71
Independent Claim
112 words
A method for imaging an article within a patient's body, said method comprising: introducing to the patient's body an article comprising a non-metallic member having paramagnetic ionic particles dispersed directly in a material matrix thereof at a concentration in the material matrix in the range from 0.1% to 20% by weight, wherein the non-metallic member is composed of an organic polymer and the paramagnetic ionic particles comprise paramagnetic metal ions entrapped together with a proton-donating fluid in a carrier particle; and imaging the body using a magnetic imaging device, whereby the article will produce an image which will have enhanced detectability irrespective of the orientation of the article to the magnetic field.
Claim 72
Independent Claim
112 words
A method for imaging an article within a patient's body, said method comprising: introducing to the patient's body an article comprising a non-metallic member having paramagnetic ionic particles dispersed directly in a material matrix thereof at a concentration in the material matrix in the range from 0.1% to 20% by weight, wherein the non-metallic member is composed of an organic polymer and the paramagnetic ionic particles comprise paramagnetic metal ions entrapped together with a proton-donating fluid in a carrier particle; and imaging the body using a magnetic imaging device, whereby the article will produce an image which will have enhanced detectability irrespective of the orientation of the article to the magnetic field.
Claim 73
Dependent Claim
12 words
A method as in claim 64, wherein the article comprises a catheter.
Claim 74
Dependent Claim
12 words
A method as in claim 64, wherein the article comprises an implant.
Claim 75
Dependent Claim
12 words
A method as in claim 64, wherein the proton-donating fluid is water.
Claim 76
Dependent Claim
15 words
A method as in claim 64, wherein the carrier particle is an ion exchange resin.
Claim 77
Dependent Claim
15 words
A method as in claim 67, wherein the carrier particle is an ion exchange resin.
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