US5818048A
Expired / Lapsed
US
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Rapid non-invasive optical analysis using broad bandpass spectral processing
Assignee: Optix LP
•
Filing: 1994-11-03
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Granted: 1998-10-06
•
Expires: 2014-11-03
Abstract
Abstract The present invention provides a generally applicable apparatus and method for achieving measurements of a constituent in a sample. This is achieved by employing a detection means having a plurality of detectors responsive to radiation in a selected region of the spectrum, e.g., the infrared. In most embodiments, at least two of the detectors provide broad wavelength bandpass. If narrow bandpass sources or detectors are used, the information generated is processed in a manner similar to broadband information. The broad bandpass response of the detectors can be contrasted with the approach of classical spectrophotometry, in which the spectral response of the detectors is designed to be as narrow as feasible, and substantially narrower than the spectral features of the constituent or constituents of interest. The data is processed such that the contributions of known background constituents and scattering is eliminated prior to further processing, thereby yielding a better result in high background situations. The use of intensity processing rather than absorbance processing also allows the method and apparatus to be used in a variety of non-ideal situations.
Inventors
- 👤 Lester Sodickson
- 👤 Howard E. Guthermann
- 👤 Myron J. Block
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:12
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/47; G01N21/4795; A; A61; A61B; A61B5/00; A61B5/0059; A61B5/145; A61B5/14532; A61B5/14546; A61B5/1455; A61B5/68; A61B5/6801; A61B5/6813; A61B5/6825; A61B5/6826; A61B5/683; A61B5/6838; G01N21/25; G01N21/31; G01N21/35; G01N21/359; G01N2021/3129; G01N2021/3137
Claims Analysis
Total Claims: 66
Claim 1
Independent Claim
139 words
An apparatus for determining, the concentration of a constituent of interest in a sample which has transmittance, emission or reflectance in a selected region of the spectrum comprising: a radiation source which generates a spectrum of illuminating radiation for illuminating at least a portion of said sample; detection means in the form of three or more detectors adapted to generate an output, each of said detectors having a spectral response in a portion of said spectrum of illuminating radiation emitted by said radiation source, at least one of said detectors having a broadband spectral response, at least one of said detectors further having an overlap in spectral response with another of said detectors; and analysis means for analyzing said outputs from said detectors to generate a signal indicative of the concentration of said constituent of interest in said sample.
Claim 2
Independent Claim
139 words
An apparatus for determining, the concentration of a constituent of interest in a sample which has transmittance, emission or reflectance in a selected region of the spectrum comprising: a radiation source which generates a spectrum of illuminating radiation for illuminating at least a portion of said sample; detection means in the form of three or more detectors adapted to generate an output, each of said detectors having a spectral response in a portion of said spectrum of illuminating radiation emitted by said radiation source, at least one of said detectors having a broadband spectral response, at least one of said detectors further having an overlap in spectral response with another of said detectors; and analysis means for analyzing said outputs from said detectors to generate a signal indicative of the concentration of said constituent of interest in said sample.
Claim 3
Dependent Claim
19 words
The apparatus of claim 1 wherein at least two of said three or more detectors comprise overlapping broadband detectors.
Claim 4
Dependent Claim
16 words
The apparatus of claim 1 wherein at least two of said detectors comprise non-overlapping broadband detectors.
Claim 5
Dependent Claim
16 words
The apparatus of claim 1 wherein said illuminating radiation comprises infrared radiation between about 700-2500 nm.
Claim 6
Dependent Claim
40 words
The apparatus of claim 4 wherein said analysis means generates an output which is an analog of a location in an n-dimensional colorimetric space, where n is equal to, or less than, the number of detectors in said detection means.
Claim 7
Dependent Claim
33 words
The apparatus of claim 1 wherein said detection means further comprises a separate black/white luminosity detector which is responsive to and overlaps said spectral response of all of said three or more detectors.
Claim 8
Dependent Claim
13 words
The apparatus of claim 1 wherein said analysis means comprises a neural network.
Claim 9
Dependent Claim
43 words
The apparatus of claim 1 wherein at least one of said detectors comprises a filter which transmits or reflects a portion of the spectrum of illuminating radiation, said filter acting, at least in part, to generate the spectral response characteristics of said detector.
Claim 10
Dependent Claim
42 words
The apparatus of claim 1 wherein at least one of said detectors is formed, at least in part, from a material selected from the group consisting of silicon photocells, lead selenide cells, indium gallium arsenide cells, germanium cells, and lead sulfide cells.
Claim 11
Dependent Claim
15 words
The apparatus of claim 1 wherein said sample comprises a portion of an animal body.
Claim 12
Dependent Claim
13 words
The apparatus of claim 10 where said animal body is a human body.
Claim 13
Dependent Claim
16 words
The apparatus of claim 11 wherein said constituent of interest is an analyte of clinical interest.
Claim 14
Dependent Claim
40 words
The apparatus of claim 12 wherein said analyte of clinical interest is selected from the group consisting of glucose, glucose indicating constituents, drugs of abuse, drugs of abuse indicating constituents, alcohol, proteins, lipoproteins, hemoglobin and its variants, cholesterol, and lipids.
Claim 15
Dependent Claim
27 words
The apparatus of claim 1 wherein said detectors are located geometrically in said apparatus such that they congruently sample radiation reflected, emitted, or transmitted from said sample.
Claim 16
Dependent Claim
23 words
The apparatus of claim 14 further comprising beam splitter means to direct the radiation reflected or transmitted from said sample to said detectors.
Claim 17
Dependent Claim
36 words
The apparatus of claim 1 wherein said detection means comprises a fiber optic cable bundle containing a plurality of optical fibers which transmit radiation reflected or transmitted from said sample to said three or more detectors.
Claim 18
Dependent Claim
37 words
The apparatus of claim 16 wherein said optical fibers in said bundle have their ends distal from said detectors randomly distributed in said bundle so as to achieve substantially equivalent illumination for each detector from said sample.
Claim 19
Dependent Claim
29 words
The apparatus of claim 1 comprising at least a first detection means and a second detection means, each of said detection means having a distinct set of detectors therein.
Claim 20
Dependent Claim
22 words
The apparatus of claim 18 wherein at least one of said first and second detection means is arranged to provide incongruent measurement.
Claim 21
Dependent Claim
63 words
The apparatus of claim 18 wherein said analysis means comprises means to compare responses from each of said detection means to generate an information signal indicative of the concentration of said constituent of interest while rendering the interfering features of the background from each of said detection means to be less distinct than it is in the response from the individual detection means.
Claim 22
Dependent Claim
26 words
The apparatus of claim 18 wherein said first detection means and said second detection means are arranged to obtain radiation from different portions of said sample.
Claim 23
Dependent Claim
26 words
The apparatus of claim 1 wherein said analysis means is arranged such that the outputs from said detectors are combined before any additional mathematical processing occurs.
Claim 24
Dependent Claim
18 words
The apparatus of claim 22 wherein said analysis means provides mathematical processing of intensity rather than absorbance values.
Claim 25
Dependent Claim
25 words
The apparatus of claim 1 wherein said analysis means comprises means to eliminate responses generated from known background components prior to any additional mathematical processing.
Claim 26
Dependent Claim
19 words
The apparatus of claim 1 wherein said apparatus comprises interrogation means which collects outputs from said detectors substantially simultaneously.
Claim 27
Dependent Claim
46 words
The apparatus of claim 25 wherein said interrogation means collects outputs from said detectors in a sufficiently rapid manner to observe a distinct arterial pulse wave form so as to allow differentiation of constituents of interest in arterial blood, as opposed to venous blood or tissue.
Claim 28
Dependent Claim
24 words
The apparatus of claim 1 wherein said detectors are located such that they obtain radiation from said sample only within a restricted solid angle.
Claim 29
Dependent Claim
28 words
The apparatus of claim 1 wherein at least a portion of said illuminating radiation is directed through a reference material to an additional detector to generate reference values.
Claim 30
Dependent Claim
15 words
The apparatus of claim 1 wherein said radiation source comprises at least two radiation sources.
Claim 31
Dependent Claim
15 words
The apparatus of claim 29 wherein said radiation sources are arranged to provide congruent illumination.
Claim 32
Dependent Claim
34 words
The apparatus of claim 29 wherein said radiation sources are arranged such that a fiber optic cable bundle containing a plurality of optical fibers can transmit radiation from said radiation sources to said sample.
Claim 33
Dependent Claim
32 words
The apparatus of claim 1 wherein at least a portion of said illuminating radiation is directed through a reference material to a detector on a time shared basis to generate reference values.
Claim 34
Independent Claim
192 words
A method for determining the concentration of a constituent of interest in a sample which has transmittance, emittance, or reflectance in a selected region of the spectrum comprising the steps of: illuminating at least a portion of said sample with a radiation source which generates a spectrum of illuminating radiation; detecting radiation reflected, emitted, or transmitted by said sample with detection means in the form of three or more detectors adapted to generate an output, each of said detectors having a spectral response in a portion of said spectrum of illuminating radiation emitted by said radiation source; generating a processing input signal which is responsive to selected aspects of the background of the detection system and the sample, and said constituent of interest, utilizing the output from a broadband detector, or combining the outputs from some of said detectors to simulate broadband detection, at least one of said detectors further having an overlap in spectral response with another of said detectors; and analyzing some of said outputs and said processing input signal with an analysis means which generates a response indicative of the concentration of said constituent of interest in said sample.
Claim 35
Independent Claim
192 words
A method for determining the concentration of a constituent of interest in a sample which has transmittance, emittance, or reflectance in a selected region of the spectrum comprising the steps of: illuminating at least a portion of said sample with a radiation source which generates a spectrum of illuminating radiation; detecting radiation reflected, emitted, or transmitted by said sample with detection means in the form of three or more detectors adapted to generate an output, each of said detectors having a spectral response in a portion of said spectrum of illuminating radiation emitted by said radiation source; generating a processing input signal which is responsive to selected aspects of the background of the detection system and the sample, and said constituent of interest, utilizing the output from a broadband detector, or combining the outputs from some of said detectors to simulate broadband detection, at least one of said detectors further having an overlap in spectral response with another of said detectors; and analyzing some of said outputs and said processing input signal with an analysis means which generates a response indicative of the concentration of said constituent of interest in said sample.
Claim 36
Dependent Claim
16 words
The method of claim 33 wherein said illuminating radiation comprises infrared radiation between about 700-2500 nm.
Claim 37
Dependent Claim
40 words
The method of claim 33 wherein said analysis means generates a response which is an analog of a location in an n-dimensional colorimetric space, where n is equal to, or less than, the number of detectors in said detection means.
Claim 38
Dependent Claim
20 words
The method of claim 33 wherein said analysis step is carried out, at least in part, by a neural network.
Claim 39
Dependent Claim
55 words
The method of claim 33 further comprising the step of normalizing the intensity of all the radiation transmitted, emitted, or reflected from said sample without regard to wavelength by including in said detection means a black/white luminosity detector which is responsive to and overlaps said spectral response of all of said three or more detectors.
Claim 40
Dependent Claim
43 words
The method of claim 33 wherein at least one of said detectors comprises a filter which transmits or reflects a portion of the spectrum of illuminating radiation, said filter acting, at least in part, to generate the spectral response characteristics of said detector.
Claim 41
Dependent Claim
16 words
The method of claim 33 wherein at least one of said detectors is a broadband detector.
Claim 42
Dependent Claim
16 words
The method of claim 39 wherein at least two of said detectors have overlapping spectral characteristics.
Claim 43
Dependent Claim
22 words
The method of claim 39 wherein the outputs of at least said broadband detector forms an input to said processing input signal.
Claim 44
Dependent Claim
42 words
The method of claim 33 wherein at least one of said detectors is formed, at least in part, of a material selected from the group consisting of silicon photocells, lead selenide cells, indium gallium arsenide cells, germanium cells, and lead sulfide cells.
Claim 45
Dependent Claim
37 words
The method of claim 33 wherein said method is directed at determining the concentration in vivo of an analyte of clinical interest in a portion of a human body and said method is used for non-invasive testing.
Claim 46
Dependent Claim
41 words
The method of claim 33 wherein said method is directed at determining the concentration in vitro of an analyte of clinical interest from a human body and said method is used on a fluid or tissue sample removed from said body.
Claim 47
Dependent Claim
41 words
The method of claim 44 wherein said analyte of clinical interest is selected from the group consisting of glucose, glucose indicating constituents, drugs of abuse, drugs of abuse indicating constituents, pharmaceuticals, alcohol, proteins, lipoproteins, hemoglobin and its variants, cholesterol, and lipids.
Claim 48
Dependent Claim
28 words
The method of claim 33 wherein said detectors are located geometrically relative to said sample such that they congruently sample radiation reflected, emitted, or transmitted from said sample.
Claim 49
Dependent Claim
30 words
The method of claim 46 wherein beam splitters are used to direct the radiation reflected, emitted, or transmitted from said sample to said detectors so as to achieve congruent sampling.
Claim 50
Dependent Claim
36 words
The method of claim 33 wherein said radiation reflected, emitted, or transmitted from said sample to said detectors is transmitted to said detection means by a fiber optic cable bundle containing a plurality of optical fibers.
Claim 51
Dependent Claim
37 words
The method of claim 48 wherein said optical fibers in said bundle have their ends distal from said detectors randomly distributed in said bundle so as to achieve substantially equivalent illumination to each detector from said sample.
Claim 52
Dependent Claim
39 words
The method of claim 33 comprising the step of generating distinct outputs from individual detectors in at least a first detection means and a second detection means, each of said detection means having a selected set of detectors therein.
Claim 53
Dependent Claim
59 words
The method of claim 50 comprising the step of comparing responses generated from data from each of said detection means to generate information indicative of the concentration of said constituent of interest while rendering the interfering features of the backgrounds from each of said detection means to be less distinct than if only a single detection means was used.
Claim 54
Dependent Claim
24 words
The method of claim 51 wherein said first and second detection means obtain radiation transmitted, emitted or reflected from different portions of said sample.
Claim 55
Dependent Claim
20 words
The method of claim 50 wherein one of said first and second detectors means is arranged to provide incongruent measurement.
Claim 56
Dependent Claim
24 words
The method of claim 33 wherein said outputs and said processing input signals from said detectors are combined before any additional mathematical processing occurs.
Claim 57
Dependent Claim
21 words
The method of claim 54 wherein mathematical processing by said analysis means is carried out on intensity rather than absorbance values.
Claim 58
Dependent Claim
30 words
The method of claim 54 wherein the analyzing of said outputs and said processing input signals comprises eliminating responses generated from known background components prior to any additional mathematical processing.
Claim 59
Dependent Claim
27 words
The method of claim 33 wherein said outputs from each of said detectors are sampled by an interrogation device sufficiently rapidly so as to be substantially simultaneous.
Claim 60
Dependent Claim
40 words
The method of claim 57 wherein said interrogation device collects said outputs from said detectors in a sufficiently rapid manner to observe a distinct arterial pulse wave form so as to allow differentiation of constituents of interest in arterial blood.
Claim 61
Dependent Claim
19 words
The method of claim 33 wherein radiation from said sample is obtained only from within a restricted solid angle.
Claim 62
Dependent Claim
28 words
The method of claim 33 wherein at least a portion of said illuminating radiation is directed through a reference material to an additional detector to generate reference values.
Claim 63
Dependent Claim
17 words
The method of claim 33 wherein said illuminating radiation is generated by at least two radiation sources.
Claim 64
Dependent Claim
15 words
The method of claim 61 wherein said radiation sources are arranged to provide congruent illumination.
Claim 65
Dependent Claim
54 words
The method of claim 61 wherein said radiation sources transmit radiation to said sample through optical fiber bundles and the optical fibers in said bundle have their ends distal from said radiation sources randomly distributed in said bundle so as to achieve substantially equivalent illumination from each of said radiation sources to said sample.
Claim 66
Dependent Claim
32 words
The method of claim 33 wherein at least a portion of said illuminating radiation is directed through a reference material to a detector on a time share basis to generate reference values.
References Cited (Backward Citations)
DE233873C
Cited
US4178917A
Cited
US4278538A
Cited
US4286327A
Cited
EP0030610B1
Cited
US4641973A
Cited
US4520265A
Cited
US4543481A
Cited
SU1187032A1
Cited
US4799795A
Cited
US4655225A
Cited
WO1988001128A2
Cited
US4805623A
Cited
US4883953A
Cited
US4882492A
Cited
US4850365A
Cited
US4928014A
Cited
US5028787A
Cited
US4975581A
Cited
US5070874A
Cited
US5054487A
Cited
US5321565A
Cited
US5321265A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 7.5 Years (Year 8) | 2005-10-05 | 2006-04-06 | 2006-10-06 | $3760.00 | Window Closed / Lapsed |
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