US5824080A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Photochemistry for the preparation of biologic grafts--allografts and xenografts
Assignee: General Hospital Corp
•
Filing: 1996-09-04
•
Granted: 1998-10-20
•
Expires: 2016-09-04
Abstract
Abstract Photodynamic therapy (PDT), a technique to produce cytotoxic free radicals, was used to prepare arterial allografts. After impregnation with the photo-sensitizer chloroaluminum sulfonated phthalocyanine, aortas of ACI rats were PDT-treated and transplanted in Lewis rats. PDT grafts were completely reendothelialized by 4 weeks.
Inventors
- 👤 Glenn M. Lamuraglia
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:29
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61K; A61K31/00; A61K31/33; A61K31/555; A61K41/00; A61K41/0023; A61L27/54; A61L2300/00; A61L2300/20; A61L2300/224; A61L2300/40; A61L2300/442
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
78 words
A method for reducing host rejection of a biologic graft, said method comprising the steps of: (a) contacting a tissue graft with a photosensitizing compound, and (b) exposing said graft to electromagnetic radiation for a predetermined time and in an amount effective to transform the photosensitizing compound into an excited state, wherein said exposure results in the activation of the photosensitizing compound to produce an activated free-radical moiety which causes the death of rejection-inducing cells of the graft.
Claim 2
Independent Claim
78 words
A method for reducing host rejection of a biologic graft, said method comprising the steps of: (a) contacting a tissue graft with a photosensitizing compound, and (b) exposing said graft to electromagnetic radiation for a predetermined time and in an amount effective to transform the photosensitizing compound into an excited state, wherein said exposure results in the activation of the photosensitizing compound to produce an activated free-radical moiety which causes the death of rejection-inducing cells of the graft.
Claim 3
Dependent Claim
24 words
The method of claim 1, wherein said graft comprises an extracellular matrix and an amorphous ground substance comprising at least one proteoglycan or glycosaminoglycan.
Claim 4
Dependent Claim
25 words
The method of claim 1, wherein said photosensitizing compound is a sulfonated chloroaluminum phthalocyanine, bacteriochlorophyll a, benzophorphyrin derivative-monoacid, mono-L-aspartyl chlorine 6, N'-bis(2-ethyl-1,3-dioxolane)kryptocyanine, or dihematoporphyrin ether.
Claim 5
Dependent Claim
18 words
The method of claim 1, wherein the wavelength of said electromagnetic radiation is between 180 and 800 nanometers.
Claim 6
Dependent Claim
13 words
The method of claim 1, wherein said graft is an allograft or xenograft.
Claim 7
Dependent Claim
36 words
The method of claim 1, wherein said graft is selected from the group consisting of artery, vein, cardiac valve, capsular tissue, tendon, ligament, cartilaginous tissue, bone, skin, intraocular lens, corneal tissue, vascular tissue, and cardiac tissue.
Claim 8
Dependent Claim
13 words
The method of claim 6, wherein said graft is an artery or vein.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-10-19 | 2002-04-20 | 2002-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-10-19 | 2006-04-20 | 2006-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-10-19 | 2010-04-20 | 2010-10-20 | $7700.00 | Window Closed / Lapsed |