US5876446A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Porous prosthesis with biodegradable material impregnated intersticial spaces
Assignee: The University of Texas System
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Filing: 1996-12-20
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Granted: 1999-03-02
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Expires: 2016-12-20
Abstract
Abstract Medical devices, most particularly prosthesis, are defined having at least one porous tissue-mating surface. The tissue-mating surface of the device includes therein a biodegradable carrier, such as a biodegradable polymer. The pores or intersticial spaces of the tissue-mating surface of the device are impregnated with the biodegradable polymer. The prosthesis of the present invention provides for enhanced rigid fixation, as pores at the surface of said device provide for bony ingrowth as the biodegradable carrier, i.e., polymer, degrades. Methods for preparing said prosthesis are described. Methods for delivering a pharmacologically active substance by including a pharmacologically active substance in the biodegradable carrier (e.g., polymer) are also disclosed.
Inventors
- 👤 C. Mauli Agrawal
- 👤 Robert C. Schenck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 15:26
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61F2/32; A61F2/40; A61F2/42; A61F2/50; A61F2/54; A61F2/58; A61F2/582; A61F2/60; A61F2/66; A61L; A61L27/00; A61L27/02; A61L27/04; A61L27/042; A61L27/045; A61L27/06; A61L27/14; A61L27/18; A61L27/50; A61L27/56; A61F2/3094; A61F2/36; A61F2/3662; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30064; A61F2002/30667; A61F2002/30677; A61F2/3609; A61F2002/3611; A61F2002/3625; A61F2002/3631; A61F2310/00; A61F2310/00389; A61F2310/0097; A61F2310/00976
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
85 words
A metallic press fit prosthetic device comprising at least one porous tissue mating surface on said metallic press fit prosthetic device having interstitial spaces impregnated with a polymer selected from a group consisting of PLA, PGA, and PLA-PGA copolymer, said polymer having a molecular weight of about 40 to 100,000 kDa and said polymer further containing a pharmacologically active substance, wherein release of said substance at the surface is controlled over a therapeutically effective period of time, when said device is implanted in a patient.
Claim 2
Dependent Claim
85 words
A metallic press fit prosthetic device comprising at least one porous tissue mating surface on said metallic press fit prosthetic device having interstitial spaces impregnated with a polymer selected from a group consisting of PLA, PGA, and PLA-PGA copolymer, said polymer having a molecular weight of about 40 to 100,000 kDa and said polymer further containing a pharmacologically active substance, wherein release of said substance at the surface is controlled over a therapeutically effective period of time, when said device is implanted in a patient.
Claim 3
Dependent Claim
14 words
The prosthetic device of claim 1 wherein the tissue-mating surface is a bone-mating surface.
Claim 4
Dependent Claim
22 words
The prosthetic device of claim 1 wherein the PLA-PGA copolymer is a copolymer of about 50% polylactic and about 50% polyglycolic acid.
Claim 5
Dependent Claim
14 words
The prosthetic device of claim 1 wherein the device is a total joint prosthesis.
Claim 6
Dependent Claim
30 words
The prosthetic device of claim 1 wherein the device is a hip, knee, shoulder, elbow, ankle, wrist, hand, finger joint, temporal mandibular joint, dental implant, or acetabular cup implant prosthesis.
Claim 7
Dependent Claim
13 words
The prosthetic device of claim 5 wherein the device is a knee prosthesis.
Claim 8
Dependent Claim
14 words
The prosthetic device of claim 1 wherein the pharmacologically active substance is an antibiotic.
Claim 9
Dependent Claim
22 words
The prosthetic device of claim 2 wherein the porous bone-mating surface comprises a cobalt chrome alloy, a titanium alloy, or stainless steel.
Claim 10
Independent Claim
64 words
A method of delivering a pharmacologically active agent comprising implanting into an animal a metallic press-fit prosthetic device comprising at least one microporous tissue mating surface having interstitial spaces impregnated with a polymer selected from the group consisting of PLA, PGA, and PLA-PGA copolymer, said polymer having a molecular weight of about 40 to 100,000 kDa, said polymer further comprising a pharmacologically active agent.
Claim 11
Independent Claim
64 words
A method of delivering a pharmacologically active agent comprising implanting into an animal a metallic press-fit prosthetic device comprising at least one microporous tissue mating surface having interstitial spaces impregnated with a polymer selected from the group consisting of PLA, PGA, and PLA-PGA copolymer, said polymer having a molecular weight of about 40 to 100,000 kDa, said polymer further comprising a pharmacologically active agent.
Claim 12
Dependent Claim
22 words
The method of claim 9 wherein the PLA-PGA copolymer is a co-polymer of about 50% polylactic acid and about 50% polyglycolic acid.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 7.5 Years (Year 8) | 2006-03-01 | 2006-08-31 | 2007-03-02 | $3760.00 | Window Closed / Lapsed |
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