US6048966A
Expired / Lapsed
US
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Fibrin sealant compositions and methods for utilizing same
Assignee: Bristol Myers Squibb Co
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Filing: 1997-12-23
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Granted: 2000-04-11
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Expires: 2017-12-23
Abstract
Abstract The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.
Inventors
- 👤 Peter A. D. Edwardson
- 👤 John E. Fairbrother
- 👤 Ronald S. Gardner
- 👤 Derek A. Hollingsbee
- 👤 Stewart A. Cederholm-Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 23:09
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/10; A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/36; A61K38/363; A61K38/43; A61K38/45; A61K38/46; A61K38/48; A61K38/482; A61K38/4833; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L17/00; A61L17/005; A61L24/00; A61L24/001; A61L24/0015; A61L24/04; A61L24/10; A61L24/106; A61L27/00; A61L27/14; A61L27/22; A61L27/225; A61P; A61P7/00; A61P7/04; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/75; C12N11/06; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/254; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/416; A61L2300/418; A61L2300/45
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
71 words
A method of preparing a fibrin sealant, which comprises a fibrin polymer, at a desired site comprising (a) subjecting fibrinogen to an enzyme which catalyzes the cleavage of fibrinopeptide A and/or B from fibrinogen to provide a nondynamic fibrin monomer; and (b) applying said nondynamic fibrin monomer and greater than 10 and up to 100% of said enzyme to said desired site under polymerizing conditions whereby a fibrin sealant is formed.
Claim 2
Independent Claim
71 words
A method of preparing a fibrin sealant, which comprises a fibrin polymer, at a desired site comprising (a) subjecting fibrinogen to an enzyme which catalyzes the cleavage of fibrinopeptide A and/or B from fibrinogen to provide a nondynamic fibrin monomer; and (b) applying said nondynamic fibrin monomer and greater than 10 and up to 100% of said enzyme to said desired site under polymerizing conditions whereby a fibrin sealant is formed.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein said enzyme cleaves substantially only fibrinopeptide A from fibrinogen.
Claim 4
Dependent Claim
10 words
The method of claim 1 wherein said enzyme is batroxobin.
Claim 5
Dependent Claim
28 words
The method of claim 3 wherein said nondynamic fibrin monomer and enzyme applied to said desired site includes from about 20 to about 200 batroxobin units of batroxobin.
References Cited (Backward Citations)
US4429040A
Cited
US5188940A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-04-11 | 2003-10-11 | 2004-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-04-11 | 2007-10-11 | 2008-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-04-11 | 2011-10-11 | 2012-04-11 | $7700.00 | Window Closed / Lapsed |