US6107326A
Expired / Lapsed
US
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Porphycenes for treatment of microbial populations
Assignee: Cytopharm Inc
•
Filing: 1999-04-12
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Granted: 2000-08-22
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Expires: 2019-04-12
Abstract
Abstract Cationic porphycenes are conjugated, through a carboxylic-acid bearing moiety, with polylysine through an amide linkage. The novel porphycenes are effective in treating microbial populations in vitro or in vivo and topically as well as for sterilizing articles.
Inventors
- 👤 Giulio Jori
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 02:35
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/22; A; A61; A61K; A61K41/00; A61K41/0057; A61K41/0071
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
10 words
A porphycene compound, comprising a porphycene in conjugation with polylysine.
Claim 2
Dependent Claim
10 words
A porphycene compound, comprising a porphycene in conjugation with polylysine.
Claim 3
Dependent Claim
16 words
The porphycene compound of claim 1 wherein said polylysine has a viscosity molecular weight of 500-30,000.
Claim 4
Dependent Claim
16 words
The porphycene compound of claim 1 wherein said polylysine has a viscosity molecular weight preferably 1,000-10,000.
Claim 5
Dependent Claim
18 words
The porphycene compound of claim 1 wherein said polylysine has a viscosity molecular weight of 1,00 to 4,000.
Claim 6
Dependent Claim
68 words
The porphycene compound of claim 1, wherein said porphycene is of formula I, ##STR4## where R is a C 1-20 alkyl or C 1-20 alkoxy C 1-20 alkyl; and X is a substituent covalently bound to the porphycene marcrocycle through an oxygen atom or a nitrogen atom, and bearing at least one carboxylic acid function through which X is conjugated to a polylysine moiety via an amide link.
Claim 7
Dependent Claim
17 words
The porphycene compound of claim 5, 9-(glutaric acid amide)-2,7,12,17-tetrakis(methoxyethyl) porphycene conjugated with polylysine of molecular weight 1,000-4,000.
Claim 8
Dependent Claim
18 words
The porphycene compound of claim 5, 9-(p-benzyloxy carboxylic acid)-2,7,12,17-tetrakis (methoxyethyl) porphycene conjugated with polylysine of molecular weight 1,000-4,000.
Claim 9
Dependent Claim
37 words
The porphycene compound of claim 5, wherein X═NHCO(CH 2 ) n CO 2 H, where n=1-10, X═OCH 2 C 6 H 4 CO 2 H or X═OCH 2 C 6 H 3 (CO 2 H) 2 .
Claim 10
Dependent Claim
36 words
The porphycene compound of claim 5, where R is n-propyl and X is a substituent bearing one or more carboxylic acid functions with conjugation via a free carboxylic acid group and an amide link with polylysine.
Claim 11
Dependent Claim
26 words
The porphycene compound of claim 1, 9-glutaric acid amide 2, 7, 12 17 tetra-n-C 1-20 alkyl porphycene conjugated with polylysinc of molecular weight 1,000 to 4,000.
Claim 12
Dependent Claim
48 words
A method of inactivating a microbial population by contacting the microbial population with the porphycene compound of claim 1 and irradiating with white light or light in the wavelength 330-750 nm, with a total light dose below the threshold needed to cause photodynamic effects on host mammalian cells.
Claim 13
Dependent Claim
16 words
The method of claim 11, wherein said wavelength of light is in the range of 570-750nm.
Claim 14
Dependent Claim
42 words
The method of claim 11 where said porphycene compound is administered in aerosol, spray solution, or liquid gel formulation to a living mammal bearing an undesirable microbial population followed by radiation with light from sources of white light, with or without filters.
Claim 15
Dependent Claim
15 words
A sterilizing composition comprising: a) the porphycene compound of claim 1; and b) a carrier.
Claim 16
Dependent Claim
21 words
The sterilizing composition of claim 14, wherein said composition is a solution and said carrier is a solvent for said porphycene.
Claim 17
Dependent Claim
13 words
The sterilizing composition of claim 14, wherein said composition is a coating composition.
Claim 18
Dependent Claim
37 words
A method of sterilizing an article comprising: a) contacting an article with the porphycene compound of claim 1; and b) irradiating said article and porphycene compound with light, for an amount and time sufficient to affect sterilization.
Claim 19
Dependent Claim
20 words
The method of claim 17, wherein contacting of said article is by immersion in a solution of said porphycene compound.
Claim 20
Dependent Claim
23 words
The method of claim 17, where contacting of said article is by coating said article with a coating composition comprising said porphycene compound.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-08-22 | 2004-02-21 | 2004-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-08-22 | 2008-02-21 | 2008-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-08-22 | 2012-02-21 | 2012-08-22 | $7700.00 | Window Closed / Lapsed |