US6132765A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug delivery via therapeutic hydrogels
Assignee: Covalon Technologies Ltd
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Filing: 1997-04-15
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Granted: 2000-10-17
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Expires: 2017-04-15
Abstract
Abstract The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.
Inventors
- 👤 Frank DiCosmo
- 👤 Valerio DiTizio
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:11
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/52; A61L27/28; A61L27/34; A61L27/54; A61L29/00; A61L29/08; A61L29/085; A61L29/14; A61L29/145; A61L29/16; A61P; A61P31/00; A61K; A61K9/00; A61K9/10; A61K9/127; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/42; A61L2300/43; A61L2300/432; A61L2300/436; A61L2300/60; A61L2300/62; A61L2300/626
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
55 words
A medical device comprising: a. a polymeric liquid conduit having an external surface; b. a gelatin hydrogel matrix material; and c. a therapeutic agent encapsulated in a liposome and confined within said matrix material, wherein said matrix material is affixed to the external surface of said polymeric liquid conduit by a plurality of covalent bonds.
Claim 2
Dependent Claim
55 words
A medical device comprising: a. a polymeric liquid conduit having an external surface; b. a gelatin hydrogel matrix material; and c. a therapeutic agent encapsulated in a liposome and confined within said matrix material, wherein said matrix material is affixed to the external surface of said polymeric liquid conduit by a plurality of covalent bonds.
Claim 3
Dependent Claim
17 words
The medical device of claim 1, wherein the gelatin hydrogel matrix material is cross-linked with polyethylene glycol.
Claim 4
Dependent Claim
14 words
The medical device of claim 1, wherein the polymeric liquid conduit comprises silicone rubber.
Claim 5
Dependent Claim
12 words
The medical device of claim 3, wherein the silicone rubber comprises polydimethylsiloxane.
Claim 6
Dependent Claim
31 words
The medical device of claim 3, comprising a bifunctional linker molecule covalently linked to an amine functionality of said gelatin and covalently linked to a methylene functionality of said silicone rubber.
Claim 7
Dependent Claim
14 words
The medical device of claim 5, wherein said linker molecule is a 4-azido-2,3,5,6-tetrafluorobenzoyl radical.
Claim 8
Dependent Claim
32 words
The medical device of claim 1, wherein the liposomal therapeutic agent is selected from the group consisting of: antibiotics, antihistamines, anti-inflammatories, hormones, steroids, growth factors, colony stimulating factors, interleukins, and combinations thereof.
Claim 9
Dependent Claim
14 words
The medical device of claim 1, wherein the liposomal therapeutic agent is an antibiotic.
Claim 10
Dependent Claim
15 words
The medical device of claim 1, wherein the liposomal therapeutic agent is a fluoroquinolone antibiotic.
Claim 11
Dependent Claim
28 words
The medical device of claim 9, wherein the fluoroquinolone antibiotic is selected from the group consisting of: ciprofloxacin, norfloxacin, ofloxacin, pefloxacin, enoxacin, rosoxacin, amifloxacin, fleroxacin, temafloxacin, and lomefloxacin.
Claim 12
Dependent Claim
11 words
The medical device of claim 9 wherein the fluoroquinolone is ciprofloxacin.
Claim 13
Dependent Claim
23 words
The medical device of claim 1, wherein the liposomes are formed of a material selected from the group consisting of dipalmitoylphosphatidylcholine and polyethyleneglycol-distearoylphosphatidylethanolamine.
Claim 14
Dependent Claim
81 words
A medical device comprising: a. a silicone rubber liquid conduit having an external surface; b. a bifunctional linker molecule comprising a fluorinated aroyl azido group convalently bound to said external surface of said liquid conduit; c. a layer of polyethylene glycol-gelatin matrix material affixed to the external surface of said liquid conduit by a covalent bond between an amine functionality of said gelatin and said bifunctional linker molecule; and d. ciprofloxacin encapsulated in a liposome and dispersed throughout said matrix material.
Claim 15
Dependent Claim
81 words
A medical device comprising: a. a silicone rubber liquid conduit having an external surface; b. a bifunctional linker molecule comprising a fluorinated aroyl azido group convalently bound to said external surface of said liquid conduit; c. a layer of polyethylene glycol-gelatin matrix material affixed to the external surface of said liquid conduit by a covalent bond between an amine functionality of said gelatin and said bifunctional linker molecule; and d. ciprofloxacin encapsulated in a liposome and dispersed throughout said matrix material.
Claim 16
Dependent Claim
64 words
A medical device comprising: a. a polymeric liquid conduit having an external surface: b. a layer of a gelatin hydrogel matrix material having a plurality of covalent bonds between a surface of the layer of hydrogel matrix material and the external surface of the liquid conduit; and c. a therapeutic agent encapsulated in a liposome and confined within said layer of said matrix material.
Claim 17
Dependent Claim
64 words
A medical device comprising: a. a polymeric liquid conduit having an external surface: b. a layer of a gelatin hydrogel matrix material having a plurality of covalent bonds between a surface of the layer of hydrogel matrix material and the external surface of the liquid conduit; and c. a therapeutic agent encapsulated in a liposome and confined within said layer of said matrix material.
Claim 18
Dependent Claim
13 words
The medical device of claim 14 wherein the liquid conduit is a catheter.
Claim 19
Dependent Claim
18 words
The medical device of claim 14 wherein the gelatin hydrogel matrix material comprises gelatin cross-linked with polyethylene glycol.
Claim 20
Dependent Claim
53 words
The medical device of claim 16 wherein the plurality of covalent bonds between the external surface of the catheter and a surface of the layer of gelatin hydrogel matrix material further comprises a linker molecule covalently bound between said external surface of said catheter and said layer of said gelatin hydrogel matrix material.
Claim 21
Dependent Claim
70 words
The medical device of claim 17 wherein the external surface of said polymeric catheter comprises silicone rubber and the linker molecule is a bifunctional aromatic compound comprising carbonyl and azide functionalities; and wherein the carbonyl fuctionality of said linker molecule is covalently bound to a free amine fuctionality of said gelatin, and the azide fuctionality of said linker molecule is covalently bound to a methylene fuctionality of said silicone rubber.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-10-17 | 2004-04-17 | 2004-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-10-17 | 2008-04-17 | 2008-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-10-17 | 2012-04-17 | 2012-10-17 | $7700.00 | Window Closed / Lapsed |