Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases

Claim 2

A compound of formula I wherein X is L 1 or L 2 Z 2 ; L 1 is (CR 3a R 3b )r or (CR 3a R 3b ) m -Z 3 -(CR 3′a /R 3′b ) n ; L 2 is (CR 3a /R 3b ) p -Z 4 -(CR 3′a /R 3′b ), or ethenyl, Z 1 is N; Z 2 is cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, heterocyclyl, substituted beterocyclyl, heterocyclenyl or substituted heterocyclenyl; Z 3 is O, NR 4 or SO; Z 4 is O, NH, S, SO S 2 or a bond; m is 0 or 1; n is 2 or 3, and n+m=2 or 3; p and q are independently 0, 1, 2, 3 or 4, and p+q=0, 1, 2, 3 or 4 when Z 4 is a bond, and p+q=0, 1, 2 or 3 when Z 4 is other than a bond; r is 2, 3 or 4; R 1a and R 1b are independently alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylcarbonyloxy, substituted heterocyclylcarbonyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, cyano, R 5 R 6 N- or acylR 5 N-, or one of R 1a and R 1b is hydrogen or halo and the other is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylcarbonyloxy, substituted heterocyclylcarbonyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, cyano, R 5 R 6 N- or acylR 5 N-; R 1c is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, halo, cyano, R 5 R 6 N- or acylR 5 N-; R 3a , R 3b , R 3′a and R 3′b are independently hydrogen or alkyl; R 4 is hydrogen, alkyl or acyl; and R 5 and R 6 are independently hydrogen or alkyl, or R 5 and R 6 taken together with the nitrogen atom to which R 5 and R 6 are attached form a heterocyclyl, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or a pharmaceutically acceptable salt thereof.

Claim 3

The compound of claim 1 wherein L 1 is (CR 3a R 3b ) m -Z 3 -(CR 3′a R 3′b ) n ; L 2 is (CR 3a R 3b ) p -Z 4 -(CR 3′a R 3′b ) q ; Z 2 is cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, heterocyclyl or substituted heterocyclyl; Z 3 and Z 4 are O or NH; m is 0; n is 2 or 3; p+q=0 or 1; R 1a and R 1b are independently alky, substituted alkyl, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy or R 5 RN-, or one of R 1a and R 1b is hydrogen or halo and the other is substituted alkyl, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyloxy, substituted heterocyclyloxy or R 5 R 6 N-; R 1c is hydrogen, alkyl substituted alkyl, alkoxy or substituted alkoxy; R 3a , R 3b , R 3+a and R 3′b are independently hydrogen or lower alkyl; and R 5 and R 6 taken together with the nitrogen atom to which R 5 and R 6 are attached form a heterocyclyl, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 4

The compound of claim 1 wherein X is L 2 Z 2 ; L 2 is (CR 3a R 3b ) p -Z 4 -(CR 3′a R 3′b ) q ; Z 2 is cycloalkyl, substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl; Z 4 is 0 or NH; p is 0; q is 0 or 1; R 1a and R 1b are independently alkyl substituted alkyl, alkoxy, substituted alkoxy, cycloalkyloxy, substituted cycloalkyloxy heterocyclyloxy or substituted heterocyclyloxy, or one of R 1a and R 1b is hydrogen or halo; R 1c is hydrogen; and R 3′a and R 3′b are independently hydrogen; or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 5

The compound of claim 1 wherein L 1 is lower alkyl.

Claim 6

The compound of claim 1 wherein Z 1 is N.

Claim 7

The compound of claim 1 wherein Z 2 is cycloalkyl or substituted cycloalkyl.

Claim 8

The compound of claim 1 wherein Z 2 is alkyl substituted monocyclic cycloalkyl.

Claim 9

The compound of claim 1 wherein Z 2 is methylcyclopentyl or methylcyclohexyl.

Claim 10

The compound of claim 1 wherein Z 2 is multicyclic cycloalkyl.

Claim 11

The compound of claim 1 wherein Z 2 is [2.2.1]bicycloheptanyl(norbornyl) or [2.2.2]bicyclooctanyl.

Claim 12

The compound of claim 1 wherein Z 2 is optionally substituted cycloalkenyl.

Claim 13

The compound of claim 1 wherein Z 2 is cyclopentenyl and cyclohexenyl.

Claim 14

The compound of claim 1 wherein Z 2 is [2.2.1]bicycloheptenyl(norbornenyl) or [2.2.2]bicyclooctenyl.

Claim 15

The compound of claim 1 wherein p and q are 0.

Claim 16

The compound of claim 1 wherein p+q=1.

Claim 17

The compound of claim 1 wherein Z 4 is O.

Claim 18

The compound of claim 1 wherein Z 4 is O, and p and q are 0.

Claim 19

The compound of claim 1 wherein Z 4 is O, and p+q =1.

Claim 20

The compound of claim 1 wherein Z 4 is NR 4 .

Claim 21

The compound of claim 1 wherein Z 4 is NR 4 , and p and q are 0.

Claim 22

The compound of claim 1 wherein Z 4 is NR 4 , and m+n=1.

Claim 23

The compound of claim 1 wherein Z 4 is S.

Claim 24

The compound of claim 1 wherein Z 4 is S, and p and q are 0.

Claim 25

The compound of claim 1 wherein Z 4 is S, and p+q=1.

Claim 26

The compound of claim 1 wherein R 1a and R 1b are independently lower alkyl hydroxy substituted lower alkyl, hydroxy, lower alkoxy, cycloalkyloxy, heterocyclyloxy, or one of R 1a and R 1b is hydrogen or halo.

Claim 27

The compound of claim 1 wherein R 1a and R 1b are independently heterocyclylcarbonyloxy lower alkoxy or substituted lower alkoxy.

Claim 28

The compound of claim 1 wherein the lower alkoxy is methoxy or ethoxy.

Claim 29

The compound of claim 1 wherein R 1a and R 1b are lower alkyl.

Claim 30

The compound of claim 1 wherein the lower alkyl is methyl or ethyl.

Claim 31

The compound of claim 1 wherein one of R 1a and R 1b is lower alkoxy, and the other of R 1a and R 1b is halo.

Claim 32

The compound of claim 1 wherein the lower alkoxy is methoxy or ethoxy, and the halo is chloro or bromo.

Claim 33

The compound of claim 1 wherein one of R 1a and R 1b is lower alkyl, and the other of R 1a and R 1b is lower alkoxy.

Claim 34

The compound of claim 1 wherein the lower alkoxy is methoxy or ethoxy, and the lower alkyl is methyl or ethyl.

Claim 35

The compound of claim 1 wherein one of R 1a and R 1b is lower alkoxy, and the other of R 1a and R 1b is cycloalkyloxy.

Claim 36

The compound of claim 1 wherein the lower alkoxy is methoxy or ethoxy, and the cycloalkyloxy is cyclopentyloxy or cyclohexyloxy.

Claim 37

The compound of claim 1 wherein one of R 1a and R 1b is hydrogen, and the other of R 1a and R 1b is lower alkoxy, cycloalkyloxy or heterocyclyloxy.

Claim 38

The compound of claim 36 wherein the lower alkoxy is methoxy or ethoxy.

Claim 39

The compound of claim 36 wherein the cycloalkyloxy is cyclopentyloxy or cyclohexyloxy.

Claim 40

The compound of claim 36 wherein the heterocyclyloxy is furanyloxy.

Claim 41

The compound of claim 1 wherein R 1c is hydrogen, lower alkyl or lower alkoxy.

Claim 42

The compound of claim 40 wherein the lower alkoxy is methoxy or ethoxy.

Claim 43

The compound of claim 1 wherein R 1a and R 1b are lower alkoxy or lower alkoxy substituted with alkoxy, heterocyclyl, carboxy, alkoxycarbonyl or carbamoyl.

Claim 44

The compound of claim 1 wherein one of R 1a and R 1b is unsubstituted lower alkoxy and the other of R 1a and R 1b is lower alkoxy substituted with alkoxy, heterocyclyl, carboxy, alkoxycarbonyl or carbamoyl.

Claim 45

The compound of claim 1 wherein one of R 1a and R 1b is methoxy and the other of R 1a and R 1b is [1,4′]-bipiperadin-1′-ylcarbonyloxy, 2-(ethoxy)ethoxy, 2-(4-morpholinyl)ethoxy, 2-(4-methylpiperazin-1-yl)ethoxy, carboxymethoxy, methoxycarbonylmethoxy, aminocarbonylmethoxy, N-methylaminocarbonylmethoxy or N,N-dimethylaminocarbonylmethoxy.

Claim 46

A compound according to claim 1 which is: 3-Cyclohexyloxy-6,7-dimethoxyquinoline; 2-cyclohexylamino-6,7-dimethoxyquinoxaline; 2-cyclohexylamino-6,7-dimethoxyquinoxaline; exo-bicyclo[2.2.1]hept-2-yl-(6-chloro-7-methoxyquinoxalin-9-yl)amine; exo-bicyclo[2.2.1]hept-2-yl-(7-chloro-6-methoxyquinoxalin-2-yl)amine; Bicyclo[2.2.1]hept-2-yl-(6,7-dimethyl-quinoxalin-2-yl)-amine; 2-cycloheptylamino-6,7-dimethoxyquinoxaline; 2-cyclopentylamino-6,7-dimethoxyquinoxaline; 2-cyclohexylamino-6-methoxyquinoxaline; 3-Aminocyclohexyl-6,7-dimethoxy-quinoline; (6,7-dimethoxy-quinolin-3-yl)-cis-(3-(R)-methyl-cyclohexyl)amine; 2-Cyclohexylamino-6-methoxy-7-bromo-quinoxaline hydrochloride; (6,7-Dimethoxyquinolin-3-yl)-cis/trans-(3-(R)-methyl-cyclohexyl)-amine (6,7-Dimethoxyquinolin-3-yl)-trans-(3-(R)-methyl-cyclohexyl)-amine (6,7-Dimethoxyquinolin-3-yl)-cis-(3-(R)-methyl-cyclohexyl)-amine; (6,7-dimethoxy-quinolin-3-yl)-(3-methyl-cyclopentyl)amine; Cyclohex-3-enyl-(6,7-dimethoxyquinoxalin-2-yl)-amine; 2,7-Bis-cyclohexyloxy-6-methoxy-quinoxaline; Cyclohexyl-(6,7-dimethoxyquinoxalin-2-ylmethyl)-amine; (6,7-Dimethoxyquinolin-3-yl)-isobutyl amine; Cyclohexyl-(6-methoxy-7-morpholin-4-yl-quinoxalin-2-yl)-amine; (±)-Bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxyquinoxalin-2-yl)-amine; exo-bicyclo[2.2.1]hept-5-en-2-yl-(6,7-dimethoxyquinoxalin-2-yl)-amine; Cyclohexyl-(6,8-dimethyl-quinoxalin-2-yl)-amine; Endo-bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxyquinoxalin-2-yl)-amine; (6,7-Dimethoxyquinoxalin-2-yl)-(4-methoxy-cyclohexyl)-amine; Exo-bicyclo[2.2.1]hept-2-yl-(6-methoxyquinoxalin-2-yl)-amine; exo-2-(Bicyclo[2.2.1]hept-2-yloxy)-6,7-dimethoxyquinoxaline; (Bicyclo[2.2.2]oct-2-yloxy)-6,7-dimethoxy-quinoxaline; Endo-2-(bicyclo[2.2.1]hept-2-yloxy)-6,7-dimethoxy-quinoxaline; exo-2-(Bicyclo[2.2.1]hept-5-en-2-yloxy)-6,7-dimethoxyquinoxaline; (Bicyclo[2.2.1]hept-5-en-2-yloxy)-6,7-dimethoxyquinoxaline; 2-Cyclohexyloxy-6,7-dimethoxyquinoxaline; 2-cyclopentylthio-6,7-dimethoxy-quinoxaline; 6,7-dimethoxy-2-cyclopentyloxy-quinoxaline; 2-cyclopentylmethyloxy-6,7-dimethoxy-quinoxaline; 6,7-dimethoxy-2-tetrahydropyran-4-oxy-quinoxaline; exo,exo-6,7-dimethoxy-2-(5,6-epoxy-bicyclo[2.2.1]beptan-2-yloxy)-quinoxaline; cis/trans-4-(6,7-Dimethoxyquinoxalin-2-yloxy)-cyclohexanecarboxylic acid; 6,7-Dimethoxy-2-(4-methoxy-cyclohexyloxy)-quinoxaline; (1R,2R,4S)-(+)-Bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxyquinoxalin-2-yl)-amine; (1S,2S,4R)-(−)-Bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxyquinoxalin-2-yl)-amine; (6,7-Dimethoxy-quinoxalin-2-yl)-2-aza-bicyclo[2.2.2]octan-3-one; Cis/trans-4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanecarboxylic acid methyl ester; Cis/trans-4-(6,7-dimethoxy-quinoxalin-2-ylamino)-cyclohexanecarboxylic acid; Cis-4-(6,7-dimethoxy-quinoxalin-2-ylamino)-cyclohexanecarboxylic acid methyl ester; Trans-4-(6,7-dimethoxy-quinoxalin-2-ylamino)-cyclohexanecarboxylic acid methyl ester; (6,7-dimethoxy-quinoxaline-2-yl)-cis/trans-(3-(R)-methylcyclohexyl)amine; (6,7-dimethoxy-quinoxaline-2-yl) -trans-(3-(R)-methylcyclohexyl)amine; (6,7-dimethoxy-quinoxaline-2-yl)-cis-(3-(R)-methylcyclohexyl)amine; or methyl cis/trans-4-(6,7-Dimethoxyquinoxalin-2-yloxy)-cyclohexanecarboxylate, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 47

A compound according to claim 1 which is 2-cyclohexylamino-6,7-dimethoxyquinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 48

A compound according to claim 1 which is exo-bicyclo[2.2.1]hept-2-yl-(6-chloro-7-methoxyquinoxalin-2-yl)amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 49

A compound according to claim 1 which is exo-bicyclo[2.2.1]hept-2-yl-(7-chloro-6-methoxyquinoxalin-2-yl)amine.

Claim 50

A compound according to claim 1 which is Bicyclo[2.2.1]hept-2-yl-(6,7-dimethyl-quinoxalin-2-yl)amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 51

A compound according to claim 1 which is 2-cycloheptylamino-6,7-dimethoxyquinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 52

A compound according to claim 1 which is 2-cyclopentylamino-6,7-dimethoxyquinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 53

A compound according to claim 1 which is Cyclohex-3-enyl-(6,7-dimethoxyquinoxalin-2-yl)-amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 54

A compound according to claim 1 which is 2,7-Bis-cyclohexyloxy-6-methoxy-quinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 55

A compound according to claim 1 which is (±)-Bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxyquinoxalin-2-yl)amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 56

A compound according to claim 1 which is exo-bicyclo[2.2.1]hept-5-en-2-yl-(6,7-dimethoxyquinoxalin-2-yl)-amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 57

A compound according to claim 1 which is Endo-bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxyquinoxalin-2-yl)-amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 58

A compound according to claim 1 which is Exo-bicyclo[2.2.1]hept-2-yl-(6-methoxyquinoxalin-2-yl)-amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 59

A compound according to claim 1 which is exo-2-(Bicyclo[2.2.1]hept-2-yloxy)-6,7-dimethoxyquinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 60

A compound according to claim 1 which is 2-(Bicyclo[2.2.2]oct-2-yloxy)-6,7-dimethoxyquinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 61

A compound according to claim 1 which is Endo-2-(bicyclo[2.2.1]hept-2-yloxy)-6,7-dimethoxyquinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 62

A compound according to claim 1 which is exo-2-(Bicyclo[2.2.1]hept-5-en-2-yloxy)-6,7-dimethoxyquinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 63

A compound according to claim 1 which is 2-(Bicyclo[2.2.1]hept-5-en-2-yloxy)-6,7-dimethoxyquinoxaline, or an N-oxide thereof, hydrate thereof; solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 64

A compound according to claim 1 which is 2-Cyclohexyloxy-6,7-dimethoxyquinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 65

A compound according to claim 1 which is 2-cyclopentylthio-6,7-dimethoxy-quinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 66

A compound according to claim 1 which is 6,7-dimethoxy-2-cyclopentyloxy-quinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 67

A compound according to claim 1 which is 2-cyclopentylmethyloxy-6,7-dimethoxy-quinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 68

A compound according to claim 1 which is 6,7-dimethoxy-2-tetrahydropyran-4-oxy-quinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 69

A compound according to claim 1 which is exo,exo-6,7-dimethoxy-2-(5,6-epoxy-bicyclo[2.2.1]heptan-2-yloxy)-quinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 70

A compound according to claim 1 which is 6,7-Dimethoxy-2-(4-methoxy-cyclohexyloxy)-quinoxaline, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 71

A compound according to claim 1 which is (1R,2R,4S)-(+)-Bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxyquinoxalin-2-yl)-amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 72

A compound according to claim 1 which is (1S,2S,4R)-(−)-Bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxyquinoxalin-2-yl)-amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 73

A compound according to claim 1 which is Cis/trans-4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanecarboxylic acid methyl ester, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 74

A compound according to claim 1 which is Cis-4-(6,7-dimethoxy-quinoxalin-2-ylamino)-cyclohexanecarboxylic acid methyl ester, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 75

A compound according to claim 1 which is Trans-4-(6,7-dimethoxy-quinoxalin-2-ylamino)-cyclohexanecarboxylic acid methyl ester, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 76

A compound according to claim 1 which is (6,7-dimethoxy-quinoxaline-2-yl)-cis/trans-(3-(R)-methylcyclohexyl)amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 77

A compound according to claim 1 which is (6,7-dimethoxy-quinoxaline-2-yl)-trans-(3-(R)-methylcyclohexyl)amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 78

A compound according to claim 1 which is (6,7-dimethoxy-quinoxaline-2-yl)-cis-(3-(R)-methylcyclohexyl)amine, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 79

A compound according to claim 1 which is methyl cis/trans-4-(6,7-Dimethoxyquinoxalin-2-yloxy)-cyclohexanecarboxylate, or an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or pharmaceutically acceptable salt thereof.

Claim 80

A pharmaceutical composition comprising the compound of claim 1 , or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.