US6528107B2
Expired / Lapsed
US
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Method for producing antimicrobial antithrombogenic medical devices
Assignee: Corcym SRL
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Filing: 1999-07-22
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Granted: 2003-03-04
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Expires: 2019-07-22
Abstract
Abstract A method is provided for producing antimicrobial, antithrombogenic medical devices. The method employs an antimicrobial treatment process wherein an antimicrobial agent is dissolved in an appropriate solvent and the resulting solution is contacted with a portion of a medical device of interest. The antimicrobial treatment process is advantageously performed without the need for additional compounds to facilitate antimicrobial agent uptake into the device. The method further comprises an antithrombogenic treatment process wherein antithrombogenic agents or materials are applied or otherwise associated with at least some portion of the medical device.
Inventors
- 👤 Joseph A. Chinn
- 👤 Richard E. Phillips, Jr.
- 👤 Joseph A. Sauter
- 👤 R. Michael Casanova
- 👤 Chandrashekhar P. Pathak
- 👤 Mark A. Moore
- 👤 L. Diane Bruce
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 15:12
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61L27/00; A61L27/14; A61L27/16; A61L27/50; A61L27/54; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2409; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/42
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
82 words
A method for treating an implantable medical device, comprising: (1) dissolving at least one antibiotic agent in a solvent consisting of methanol to form an antimicrobial solution; (2) providing an implantable medical device comprising a polymer fabric; (3) contacting the antimicrobial solution with at least a portion of the polymer fabric, under conditions effective for causing incorporation of at least some of the antibiotic agent into said polymer fabric; and (4) incorporating heparin into a least a portion of the medical device.
Claim 2
Independent Claim
82 words
A method for treating an implantable medical device, comprising: (1) dissolving at least one antibiotic agent in a solvent consisting of methanol to form an antimicrobial solution; (2) providing an implantable medical device comprising a polymer fabric; (3) contacting the antimicrobial solution with at least a portion of the polymer fabric, under conditions effective for causing incorporation of at least some of the antibiotic agent into said polymer fabric; and (4) incorporating heparin into a least a portion of the medical device.
Claim 3
Dependent Claim
26 words
The method of claim 1 , wherein said fabric is selected from the group consisting of dacron fabric, polytetrafluoroethylene fabric, polyethylene terephthalate fabric, and nylon fabric.
Claim 4
Dependent Claim
24 words
The method of claim 1 , wherein the medical device is comprised of polytetrafluoroethylene, polyethylene terepthalate, polyurethane, silicon rubber, polyethylene, cancellous titanium or hydroxyapatite.
Claim 5
Dependent Claim
35 words
The method of claim 1 , wherein the medical device is selected from the group consisting of annuloplasty rings, heart valve sewing cuffs, catheter sewing cuffs, pericardial patches, vascular grafts, sutures, pledgets, and wound dressings.
Claim 6
Dependent Claim
25 words
The method of claim 1 , wherein said contacting step comprises dipping, injecting, flushing, or spraying the antimicrobial solution into or onto the polymer fabric.
Claim 7
Dependent Claim
30 words
The method of claim 1 , wherein the antimicrobial solution is contacted with the polymer fabric for a duration in the range of about 0.1 hour to about 2 hours.
Claim 8
Dependent Claim
31 words
The method of claim 1 , wherein the antimicrobial solution that is contacted with the polymer fabric has a temperature in the range of about 10 deg.C to about 60 deg.C.
Claim 9
Dependent Claim
29 words
The method of claim 1 , wherein the concentration of the antibiotic agent in the antimicrobial solution is in the range of about 1 mg/ml to about 60 mg/ml.
Claim 10
Dependent Claim
24 words
The method of claim 1 , further comprising removing substantially all of said methanol after said antibiotic agent is incorporated into the polymer fabric.
Claim 11
Dependent Claim
16 words
The method of claim 1 , wherein the heparin is covalently bonded to the medical device.
Claim 12
Independent Claim
83 words
A method for treating an implantable medical device, comprising: (1) dissolving two or more antibiotic agents in a solvent consisting of methanol to form an antimicrobial solution; (2) providing an implantable medical device comprising a polymer fabric; (3) contacting the antimicrobial solution with at least a portion of the polymer fabric, under conditions effective for causing incorporation of at least some of the said antibiotic agents into said polymer fabric; and (4) incorporating heparin into at least a portion of the medical device.
Claim 13
Independent Claim
83 words
A method for treating an implantable medical device, comprising: (1) dissolving two or more antibiotic agents in a solvent consisting of methanol to form an antimicrobial solution; (2) providing an implantable medical device comprising a polymer fabric; (3) contacting the antimicrobial solution with at least a portion of the polymer fabric, under conditions effective for causing incorporation of at least some of the said antibiotic agents into said polymer fabric; and (4) incorporating heparin into at least a portion of the medical device.
Claim 14
Dependent Claim
24 words
The method of claim 11 , wherein the medical device is comprised of polytetrafluoroethylene, polyethylene terepthalate, polyurethane, silicon rubber, polyethylene, cancellous titanium or hydroxyapatite.
Claim 15
Dependent Claim
35 words
The method of claim 11 , wherein the medical device is selected from the group consisting of annuloplasty rings, heart valve sewing cuffs, catheter sewing cuffs, pericardial patches, vascular grafts, sutures, pledgets, and wound dressings.
Claim 16
Dependent Claim
25 words
The method of claim 11 , wherein said contacting step comprises dipping, injecting, flushing, or spraying the antimicrobial solution into or onto the polymer fabric.
Claim 17
Dependent Claim
30 words
The method of claim 11 , wherein the antimicrobial solution is contacted with the polymer fabric for a duration in the range of about 0.1 hours to about 2 hours.
Claim 18
Dependent Claim
31 words
The method of claim 11 , wherein the antimicrobial solution that is contacted with the polymer fabric has a temperature in the range of about 10 deg.C to about 60 deg.C.
Claim 19
Dependent Claim
29 words
The method of claim 11 , wherein the concentration of the antibiotic agent in the antimicrobial solution is in the range of about 1 mg/ml to about 60 mg/ml.
Claim 20
Dependent Claim
24 words
The method of claim 1 , further comprising removing substantially all of said methanol after said antibiotic agent is incorporated into the polymer fabric.
Claim 21
Dependent Claim
16 words
The method of claim 11 , wherein said heparin is covalently bonded to the medical device.
Claim 22
Dependent Claim
16 words
The method of claim 11 , wherein said heparin is ionically bonded to the medical device.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2006-03-03 | 2006-09-02 | 2007-03-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-03-03 | 2010-09-02 | 2011-03-04 | $3760.00 | Window Closed / Lapsed |
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