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US6540891B1 Expired / Lapsed US ⏱️ 0.0 years remaining

Test strip

Assignee: Abbott Laboratories
•
Filing: 1999-05-06
•
Granted: 2003-04-01
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Expires: 2019-05-06
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Abstract

Abstract An improved disposable test strip for use in amperometric measurement of analytes in complex liquid media, such as blood, which has three or more electrodes has been developed. This strip is designed so that different electrical potentials can be maintained between a common pseudo reference/counter electrode and each of the other electrodes upon the imposition of a common potential by an amperometric meter. This capability is imparted to the test strip by providing different circuit resistances for each of these other electrodes. The test strip can be utilized to measure a single analyte such as glucose with a background compensation via a “dummy” electrode or it can be used to measure the concentration of multiple analytes.

Inventors

  • 👤 Alan Andrew Stewart
  • 👤 Steven Scott

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-06 07:27
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/001; C12Q1/005; C12Q1/006; C12Q1/004

Claims Analysis

Total Claims: 24
Claim 1
Independent Claim 245 words
A disposable test strip suitable for attachment to the signal readout circuitry of a meter which performs an amperometric test to detect a current representative of the concentration of an analyte in a complex liquid medium comprising: (a) a working electrode which comprises an electrode pad coated with both a substance designed to engage said analyte in an oxidation-reduction reaction and a mediator compound which will transfer electrons between the oxidation-reduction reaction and the electrode pad; (b) a dummy electrode which comprises an electrode pad which is coated with about the same amount of mediator compound as the working electrode but lacks the substance which engages the analyte in the oxidation-reduction reaction; (c) a pseudo reference/counter electrode which comprises an electrode pad coated with a material which contains both the oxidized and reduced form of a chemical species which is designed to undergo a reduction or oxidation reaction to balance the opposite reaction at the working and dummy electrodes; and (d) three conductive tracks, each of which extends from a contact pad adapted to interface with said readout circuitry to one of the electrode pads and which is in electrical contact with both its contact pad and its electrode pad; wherein the electrical resistance in the circuit path from the contact pad connected to the dummy electrode through the dummy electrode is significantly greater than the electrical resistance in the circuit path from the contact pad connected to the working electrode through the working electrode.
Claim 2
Dependent Claim 245 words
A disposable test strip suitable for attachment to the signal readout circuitry of a meter which performs an amperometric test to detect a current representative of the concentration of an analyte in a complex liquid medium comprising: (a) a working electrode which comprises an electrode pad coated with both a substance designed to engage said analyte in an oxidation-reduction reaction and a mediator compound which will transfer electrons between the oxidation-reduction reaction and the electrode pad; (b) a dummy electrode which comprises an electrode pad which is coated with about the same amount of mediator compound as the working electrode but lacks the substance which engages the analyte in the oxidation-reduction reaction; (c) a pseudo reference/counter electrode which comprises an electrode pad coated with a material which contains both the oxidized and reduced form of a chemical species which is designed to undergo a reduction or oxidation reaction to balance the opposite reaction at the working and dummy electrodes; and (d) three conductive tracks, each of which extends from a contact pad adapted to interface with said readout circuitry to one of the electrode pads and which is in electrical contact with both its contact pad and its electrode pad; wherein the electrical resistance in the circuit path from the contact pad connected to the dummy electrode through the dummy electrode is significantly greater than the electrical resistance in the circuit path from the contact pad connected to the working electrode through the working electrode.
Claim 3
Dependent Claim 35 words
The disposable test strip of claim 1 wherein the greater electrical resistance in the dummy electrode circuit is provided by increasing the resistance of the conductive track connecting the dummy electrode to its contact pad.
Claim 4
Dependent Claim 28 words
The disposable test strip of claim 1 , further comprising an elongate support having a substantially flat, planar surface arranged to be releasably attached to the readout circuitry.
Claim 5
Dependent Claim 22 words
The disposable test strip of claim 3 wherein the three conductive tracks are created by coating conductive particles on the elongated support.
Claim 6
Dependent Claim 13 words
The disposable test strip of claim 4 wherein the conductive particles comprise carbon.
Claim 7
Dependent Claim 54 words
The disposable test strip of claim 4 wherein a greater electrical resistance is imparted to the conductive track connecting the dummy electrode to its contact pad by using a smaller volume of conductive particles in this track as compared to that used in the conductive track connecting the working electrode to its contact pad.
Claim 8
Dependent Claim 33 words
The disposable test strip of claim 1 wherein the conductive track connecting the dummy electrode to its contact pad is narrower than the conductive track connecting the working electrode to its contact pad.
Claim 9
Dependent Claim 33 words
The disposable test strip of claim 1 wherein the conductive track connecting the dummy electrode to its contact pad is thinner than the conductive track connecting the working electrode to its contact pad.
Claim 10
Dependent Claim 35 words
The disposable test strip of claim 1 wherein the conductive track connecting the dummy electrode to its contact pad has a different composition than the conductive track connecting the working electrode to its contact pad.
Claim 11
Dependent Claim 41 words
The disposable test strip of claim 9 wherein both the conductive track connected to the dummy electrode and the conductive track connected to the working electrode are comprised of carbon particles but only the latter conductive track is coated with silver.
Claim 12
Dependent Claim 33 words
The disposable test strip of claim 1 wherein the conductive track connecting the dummy electrode to its contact pad is longer than the conductive track connecting the working electrode to its contact pad.
Claim 13
Dependent Claim 26 words
The disposable test strip of claim 1 wherein the analyte is glucose and the substance engaging the analyte in an oxidation reduction reaction is an enzyme.
Claim 14
Dependent Claim 13 words
The disposable test strip of claim 12 wherein the enzyme is glucose oxidase.
Claim 15
Dependent Claim 14 words
The disposable test strip of claim 1 wherein the mediator is a ferrocene derivative.
Claim 16
Dependent Claim 25 words
The disposable test strip of claim 1 wherein said pseudo reference/counter electrode comprises an electrode pad coated with a mixture of silver and silver chloride.
Claim 17
Dependent Claim 29 words
The disposable test strip of claim 1 wherein the electrical resistance in said dummy electrode circuit is at least 1000 ohms greater than in said working electrode circuit path.
Claim 18
Dependent Claim 283 words
A disposable test strip suitable for attachment to the signal readout circuitry of a meter which performs an amperometric test to detect currents representative of the concentrations of multiple analytes in a liquid medium comprising: (a) a first working electrode which comprises an electrode pad coated with both a substance designed to engage one of the multiple analytes in an oxidation-reduction reaction at a first electrical potential difference and a mediator compound which will transfer electrons between its oxidation-reduction reaction and its electrode pad; (b) a second working electrode which comprises an electrode pad which is coated with both a substance designed to engage another of the multiple analytes in an oxidation-reduction reaction at a second electrical potential difference which is significantly greater than said first electrical potential difference and another mediator compound which will transfer electrons between its oxidation-reduction reaction and its electrode pad; (c) a pseudo reference/counter electrode which comprises an electrode pad coated with a material which contains both the oxidized and reduced form of a chemical species which is designed to undergo a reduction or oxidation reaction to balance the opposite reactions at the first and second working electrodes; and (d) three conductive tracks, each of which extends from a contact pad intended to interface with said readout circuitry to one of the electrode pads and which is in electrical contact with both its contact pad and its electrode pad; wherein the electrical resistance in the circuit path from the contact pad connected to the first working electrode through the first working electrode is significantly greater than the electrical resistance in the circuit path from the contact pad connected to the second working electrode through the second working electrode.
Claim 19
Dependent Claim 283 words
A disposable test strip suitable for attachment to the signal readout circuitry of a meter which performs an amperometric test to detect currents representative of the concentrations of multiple analytes in a liquid medium comprising: (a) a first working electrode which comprises an electrode pad coated with both a substance designed to engage one of the multiple analytes in an oxidation-reduction reaction at a first electrical potential difference and a mediator compound which will transfer electrons between its oxidation-reduction reaction and its electrode pad; (b) a second working electrode which comprises an electrode pad which is coated with both a substance designed to engage another of the multiple analytes in an oxidation-reduction reaction at a second electrical potential difference which is significantly greater than said first electrical potential difference and another mediator compound which will transfer electrons between its oxidation-reduction reaction and its electrode pad; (c) a pseudo reference/counter electrode which comprises an electrode pad coated with a material which contains both the oxidized and reduced form of a chemical species which is designed to undergo a reduction or oxidation reaction to balance the opposite reactions at the first and second working electrodes; and (d) three conductive tracks, each of which extends from a contact pad intended to interface with said readout circuitry to one of the electrode pads and which is in electrical contact with both its contact pad and its electrode pad; wherein the electrical resistance in the circuit path from the contact pad connected to the first working electrode through the first working electrode is significantly greater than the electrical resistance in the circuit path from the contact pad connected to the second working electrode through the second working electrode.
Claim 20
Dependent Claim 14 words
The disposable test strip of claim 17 wherein there are only two working electrodes.
Claim 21
Dependent Claim 25 words
The disposable test strip of claim 17 wherein the pseudo reference/counter electrode comprises an electrode pad coated with a mixture of silver and silver chloride.
Claim 22
Dependent Claim 40 words
The disposable test strip of claim 17 wherein the first working electrode comprises an enzyme system adapted to engage ketones and a suitable mediator and the second working electrode comprises an enzyme suitable to engage glucose and a suitable mediator.
Claim 23
Dependent Claim 32 words
The disposable test strip of claim 20 wherein the first working electrode comprises a HBDH/NADH/1, 10 PQ system and the second working electrode comprises a glucose oxidase and a ferrocene based mediator.
Claim 24
Dependent Claim 51 words
The disposable test strip of claim 21 wherein the resistance in the first working electrode circuit is such that when a 400 mV potential exists between the second working electrode and the pseudo reference/counter electrode there is a 200 mV potential between the first working electrode and the pseudo reference/counter electrode.

References Cited (Backward Citations)

US5509410A Cited
EP0593096A2 Cited
US5628890A Cited
WO1997030344A1 Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 2006-03-31 2006-09-30 2007-04-01 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2010-03-31 2010-09-30 2011-04-01 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2014-03-31 2014-09-30 2015-04-01 $7700.00 Window Closed / Lapsed

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