Patent US4345053A successfully refreshed from Google Patents.
US6541678B2
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US
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Immunostimulating coating for surgical devices
Assignee: STELLEN MEDICAL LLC
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Filing: 2001-03-21
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Granted: 2003-04-01
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Expires: 2021-03-21
Abstract
Abstract The present invention discloses an immunostimulating agent that may be applied to various surgical devices to promote rapid healing and the ready acceptance and integration of the surgical devices with the body tissues at the surgical site.
Inventors
- 👤 Barbara Klein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 02:51
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/20; A61L31/00; A61L31/04; A61L31/042; Y; Y10; Y10T; Y10T442/00; Y10T442/20; Y10T442/2525
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
71 words
A method of applying an immunostimulating agent to a biocompatible surgical device comprising the steps of: applying a suitable solvent to the biocompatible surgical device; applying to the wetted biocompatible surgical device a β-D-glucan powder such that the β-D-glucan powder dissolves into the solvent to form a substantially uniform coating upon the biocompatible surgical device; and evaporating the solvent from the substantially uniform coating of β-D-glucan upon the biocompatible surgical device.
Claim 2
Independent Claim
71 words
A method of applying an immunostimulating agent to a biocompatible surgical device comprising the steps of: applying a suitable solvent to the biocompatible surgical device; applying to the wetted biocompatible surgical device a β-D-glucan powder such that the β-D-glucan powder dissolves into the solvent to form a substantially uniform coating upon the biocompatible surgical device; and evaporating the solvent from the substantially uniform coating of β-D-glucan upon the biocompatible surgical device.
Claim 3
Dependent Claim
22 words
The method of applying an immunostimulating agent to a biocompatible surgical device of claim 1 wherein said β-D-glucan is a cereal-derived β-D-glucan.
Claim 4
Dependent Claim
27 words
The method of applying an immunostimulating agent to a biocompatible surgical device of claim 1 wherein said β-D-glucan is derived from one of coats, barley, and wheat.
Claim 5
Independent Claim
79 words
A method of applying an immunostimulating agent to a biocompatible surgical device comprising the steps of: preparing an aqueous solution comprising a β-D-glucan; placing the aqueous solution of β-D-glucan in a spraying mechanism; coating a predetermined portion of the surface of the biocompatible surgical device with the aqueous β-D-glucan solution by spraying the aqueous solution onto the surface of the biocompatible surgical device; and drying the aqueous solution of β-D-glucan deposited on the surface of the biocompatible surgical device.
Claim 6
Independent Claim
79 words
A method of applying an immunostimulating agent to a biocompatible surgical device comprising the steps of: preparing an aqueous solution comprising a β-D-glucan; placing the aqueous solution of β-D-glucan in a spraying mechanism; coating a predetermined portion of the surface of the biocompatible surgical device with the aqueous β-D-glucan solution by spraying the aqueous solution onto the surface of the biocompatible surgical device; and drying the aqueous solution of β-D-glucan deposited on the surface of the biocompatible surgical device.
Claim 7
Dependent Claim
22 words
The method of applying an immunostimulating agent to a biocompatible surgical device of claim 4 wherein said β-D-glucan is a cereal-derived β-D-glucan.
Claim 8
Dependent Claim
27 words
The method of applying an immunostimulating agent to a biocompatible surgical device of claim 4 wherein said β-D-glucan is derived from one of oats, barley, and wheat.
Claim 9
Independent Claim
85 words
A method of applying an immunostimulating agent to a biocompatible surgical device comprising the steps of: preparing an aqueous solution comprising a β-D-glucan; placing said aqueous solution in an electrostatically charged spraying device; placing the biocompatible surgical device upon a support structure having an electrostatic charge opposite that of the spraying device; spraying the electrostatically charged aqueous solution onto the oppositely charged biocompatible surgical device so as to form a coating thereon; and, drying the aqueous solution on the surface of the biocompatible surgical device.
Claim 10
Independent Claim
85 words
A method of applying an immunostimulating agent to a biocompatible surgical device comprising the steps of: preparing an aqueous solution comprising a β-D-glucan; placing said aqueous solution in an electrostatically charged spraying device; placing the biocompatible surgical device upon a support structure having an electrostatic charge opposite that of the spraying device; spraying the electrostatically charged aqueous solution onto the oppositely charged biocompatible surgical device so as to form a coating thereon; and, drying the aqueous solution on the surface of the biocompatible surgical device.
Claim 11
Dependent Claim
22 words
The method of applying an immunostimulating agent to a biocompatible surgical device of claim 7 wherein said β-D-glucan is a cereal-derived β-D-glucan.
Claim 12
Dependent Claim
27 words
The method of applying an immunostimulating agent to a biocompatible surgical device of claim 8 wherein said β-D-glucan is derived from one of oats, barley, and wheat.
Claim 13
Independent Claim
60 words
A method of applying an immunostimulating agent to a biocompatible surgical device comprising the steps of: applying an aqueous solution comprising β-D-glucan to the surface of a biocompatible surgical device; drawing a vacuum around the coated biocompatible surgical device; removing the biocompatible surgical device from the vacuum; and, drying the aqueous solution on the surface of the biocompatible surgical device.
Claim 14
Independent Claim
60 words
A method of applying an immunostimulating agent to a biocompatible surgical device comprising the steps of: applying an aqueous solution comprising β-D-glucan to the surface of a biocompatible surgical device; drawing a vacuum around the coated biocompatible surgical device; removing the biocompatible surgical device from the vacuum; and, drying the aqueous solution on the surface of the biocompatible surgical device.
Claim 15
Dependent Claim
22 words
The method of applying an immunostimulating agent to a biocompatible surgical device of claim 10 wherein said β-D-glucan is a cereal-derived β-D-glucan.
Claim 16
Dependent Claim
27 words
The method of applying an immunostimulating agent to a biocompatible surgical device of claim 11 wherein said β-D-glucan is derived from one of oats, barley, and wheat.
Claim 17
Dependent Claim
27 words
The method of applying an immunostimulating agent to a biocompatible surgical device of claim 10 wherein said β-D-glucan is derived from one of yeast, bacteria, and fungus.
Claim 18
Independent Claim
39 words
A method of promoting the acceptance of a surgical device into the tissues into which the surgical device is implanted, the method comprising the step of applying an immunostimulating agent comprising a β-D-glucan to the surgical device before implantation.
Claim 19
Independent Claim
39 words
A method of promoting the acceptance of a surgical device into the tissues into which the surgical device is implanted, the method comprising the step of applying an immunostimulating agent comprising a β-D-glucan to the surgical device before implantation.
Claim 20
Independent Claim
40 words
A method of promoting the acceptance of a surgical device into the tissues into which the surgical device is implanted, the method comprising the step of applying an immunostimulating agent comprising a cereal-derived β-D-glucan to the surgical device before implantation.
Claim 21
Independent Claim
40 words
A method of promoting the acceptance of a surgical device into the tissues into which the surgical device is implanted, the method comprising the step of applying an immunostimulating agent comprising a cereal-derived β-D-glucan to the surgical device before implantation.
Claim 22
Independent Claim
59 words
A method of promoting the acceptance of a surgical device into the tissues into which the surgical device is implanted, the method comprising the step of applying an immunostimulating agent to the surgical device before implantation at a surgical site, the immunostimulating agent comprising a β-D-glucan derived from one of a group comprising yeast, fungi, cereal grains, and bacteria.
Claim 23
Independent Claim
59 words
A method of promoting the acceptance of a surgical device into the tissues into which the surgical device is implanted, the method comprising the step of applying an immunostimulating agent to the surgical device before implantation at a surgical site, the immunostimulating agent comprising a β-D-glucan derived from one of a group comprising yeast, fungi, cereal grains, and bacteria.
References Cited (Backward Citations)
US4818752A
Cited
US5676967A
Cited
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