US6562037B2 — Bonding of soft biological tissues by passing hig…

Claim 1

Independent Claim 165 words

Apparatus for bonding an incision or split in soft biological tissue, the incision or split dividing the tissue into first and second portions, the apparatus comprising: a first electrode to contact the first portion of the tissue; a second electrode to contact the second portion of the tissue; means to apply pressure to the first and second electrodes to grip the first and second portions of the tissue; an electrical power source for providing a high frequency electrical signal to said electrodes to be passed through said first and second portions of said tissue; and control means coupled to said electrical power source to provide said electrodes with one voltage signal during a first of two stages, and another voltage signal during a second of said two stages, wherein the voltage signal during the second stage is sustained at a constant level equivalent to a maximum voltage of the first stage voltage signal to provide tissue welding that forms a weld to reconnect the tissue.

Claim 2

Dependent Claim 165 words

Apparatus for bonding an incision or split in soft biological tissue, the incision or split dividing the tissue into first and second portions, the apparatus comprising: a first electrode to contact the first portion of the tissue; a second electrode to contact the second portion of the tissue; means to apply pressure to the first and second electrodes to grip the first and second portions of the tissue; an electrical power source for providing a high frequency electrical signal to said electrodes to be passed through said first and second portions of said tissue; and control means coupled to said electrical power source to provide said electrodes with one voltage signal during a first of two stages, and another voltage signal during a second of said two stages, wherein the voltage signal during the second stage is sustained at a constant level equivalent to a maximum voltage of the first stage voltage signal to provide tissue welding that forms a weld to reconnect the tissue.

Claim 3

Dependent Claim 23 words

The apparatus of claim 1 , wherein said control means controls the voltage signal of said first stage to have a varying level.

Claim 4

Dependent Claim 27 words

The apparatus of claim 2 , wherein said control means provides a constant rate of increase in the voltage of said voltage signal during said first stage.

Claim 5

Dependent Claim 18 words

The apparatus of claim 3 , wherein said constant rate of increase begins at a voltage of zero.

Claim 6

Dependent Claim 31 words

The apparatus of claim 3 , wherein said constant rate of increase reaches a maximum voltage during said first stage equal to said constant voltage level applied during said second stage.

Claim 7

Dependent Claim 31 words

The apparatus of claim 2 , further comprising means for measuring impedance of said tissue, wherein said control means controls duration of said first stage in response to said measured impedance.

Claim 8

Dependent Claim 27 words

The apparatus of claim 6 , wherein said control means controls said constant voltage level of said signal during said second stage based on said measured impedance.

Claim 9

Dependent Claim 38 words

The apparatus of claim 7 , wherein said control means controls duration of said second stage based on a relative tissue impedance value derived from a ratio of said measured impedance value to a minimal impedance value thereof.

Claim 10

Dependent Claim 52 words

The apparatus of claim 2 , further comprising means for measuring impedance of said tissue as a function of time, means for detecting an impedance minimum of said tissue after said first stage commences, wherein said control means controls duration of said first stage in response to occurrence of said impedance mimimum.

Claim 11

Dependent Claim 24 words

The apparatus of claim 9 , wherein said control means controls said constant level of said signal based on occurrence of said impedance minimum.

Claim 12

Dependent Claim 52 words

The apparatus of claim 2 , wherein said control means controls duration of said second stage by terminating said second stage when a current measured tissue impedance value rises to a level equal to a predetermined ratio of the current measured value tissue impedance value of a minimum measured tissue impedance value.

Claim 13

Dependent Claim 57 words

The apparatus of claim 1 , wherein said electrodes are adapted to engage said tissue portions when said first and second tissue portions are joined together in the form of a flange which includes joined edges of tissue from both sides of said incision and said electrodes are further adapted to engage opposite sides of said flange.

Claim 14

Dependent Claim 28 words

The apparatus of claim 12 , wherein the forceps includes clamping means for applying force to clamp the flange between said electrodes to thereby compress said tissue portion.

Claim 15

Dependent Claim 19 words

The apparatus of claim 13 , wherein said clamping means compresses said flange during said first and second stages.

Claim 16

Dependent Claim 21 words

The apparatus, of claim 13 , wherein the clamping means controls said force applied to said flange to a predetermined level.

Claim 17

Dependent Claim 12 words

The apparatus of claim 13 , wherein said clamping means is mechanical.

Claim 18

Dependent Claim 12 words

The apparatus of claim 13 , wherein said clamping means is electromagnetic.

Claim 19

Dependent Claim 25 words

The apparatus of claim 14 , wherein said clamping means continues to compress said flange for a time period after said second stage is completed.

Claim 20

Dependent Claim 17 words

The apparatus of claim 18 , wherein the clamping means increases said force during said second stage.

Claim 21

Dependent Claim 19 words

The apparatus of claim 1 , wherein the power source provides a frequency between 50 kHz and 300 kHz.

Claim 22

Dependent Claim 122 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion; an electrical power source for providing a high frequency electrical signal to said electrodes to be passed through said tissue portion; and control means coupled to said electrical power source to provide said electrodes with a first voltage signal during a first of two stages, and a second voltage signal during a second of said two stages, wherein said control means modulates said second voltage level during at least said second stage by a low frequency signal to provide tissue welding that forms a weld to reconnect the tissue.

Claim 23

Dependent Claim 122 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion; an electrical power source for providing a high frequency electrical signal to said electrodes to be passed through said tissue portion; and control means coupled to said electrical power source to provide said electrodes with a first voltage signal during a first of two stages, and a second voltage signal during a second of said two stages, wherein said control means modulates said second voltage level during at least said second stage by a low frequency signal to provide tissue welding that forms a weld to reconnect the tissue.

Claim 24

Dependent Claim 21 words

The apparatus of claim 21 , wherein said low frequency signal is in the range of 4 Hz and 6 kHz.

Claim 25

Dependent Claim 110 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion; an electrical power source for providing a high frequency electrical signal to said electrodes to be passed through said tissue portion; and control means for providing a constant voltage level of said signal during at least a portion of a time period when said high frequency electrical energy is passed through said tissue portion, and for modulating said constant level by a low frequency signal to provide tissue welding that forms a weld to reconnect the tissue.

Claim 26

Dependent Claim 110 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion; an electrical power source for providing a high frequency electrical signal to said electrodes to be passed through said tissue portion; and control means for providing a constant voltage level of said signal during at least a portion of a time period when said high frequency electrical energy is passed through said tissue portion, and for modulating said constant level by a low frequency signal to provide tissue welding that forms a weld to reconnect the tissue.

Claim 27

Dependent Claim 24 words

The apparatus of claim 23 , wherein the frequency of said low frequency signal is in the range of 4 Hz to 6 kHz.

Claim 28

Dependent Claim 16 words

The apparatus of claim 24 , wherein said low frequency signal is a substantially square pulse.

Claim 29

Dependent Claim 210 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion; an electrical power source for providing an electrical signal to said electrodes to be passed through said tissue portion; means for providing a gradually increasing electrical signal to said tissue portion; means for measuring an impedance of said tissue portion as a function of time while said electrical signal passes through said tissue portion; means for determining and memorizing a minimum impedance while a gradually increasing electrical signal passes through said tissue portion; means for stabilization of the electrical signal at a level correspoinding to said minimum value of tissue impedance at a time following said period of gradual increase of the electrical signal; means for determining said tissue portion impedance relative to its said minimum value while said electrical signal passes through said tissue poirtion after the impedance has reached its minimum value; and means for stopping said electrical signal from being passed through said tissue portion when said tissue portion impedance value relative to its minimum impedance value reaches a preset level, said preset level being specific in particular to the biological tissue being bonded.

Claim 30

Dependent Claim 210 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion; an electrical power source for providing an electrical signal to said electrodes to be passed through said tissue portion; means for providing a gradually increasing electrical signal to said tissue portion; means for measuring an impedance of said tissue portion as a function of time while said electrical signal passes through said tissue portion; means for determining and memorizing a minimum impedance while a gradually increasing electrical signal passes through said tissue portion; means for stabilization of the electrical signal at a level correspoinding to said minimum value of tissue impedance at a time following said period of gradual increase of the electrical signal; means for determining said tissue portion impedance relative to its said minimum value while said electrical signal passes through said tissue poirtion after the impedance has reached its minimum value; and means for stopping said electrical signal from being passed through said tissue portion when said tissue portion impedance value relative to its minimum impedance value reaches a preset level, said preset level being specific in particular to the biological tissue being bonded.

Claim 31

Dependent Claim 24 words

The apparatus of claim 26 , wherein said measuring means includes a voltage sensor, a current sensor and means to calculate a ratio therebetween.

Claim 32

Dependent Claim 96 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion in an electrode/tissue contact area; an electrical power source for providing a high frequency electrical signal to said electrodes to be passed through said tissue portion; and wherein a dimension of said electrodes is selected relative to a thickness of said tissue portion in order to avoid overheating of the electrodes to provide tissue welding that forms a weld to reconnect the tissue.

Claim 33

Dependent Claim 96 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion in an electrode/tissue contact area; an electrical power source for providing a high frequency electrical signal to said electrodes to be passed through said tissue portion; and wherein a dimension of said electrodes is selected relative to a thickness of said tissue portion in order to avoid overheating of the electrodes to provide tissue welding that forms a weld to reconnect the tissue.

Claim 34

Dependent Claim 33 words

The apparatus of claim 28 , wherein said electrodes are dimensioned such that a linear dimension of said electrode/tissue contact area is at least as large as a thickness of said tissue portion.

Claim 35

Dependent Claim 176 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion; an electrical power source for providing an electrical signal to said electrodes to be passed through said tissue portion, wherein said signal includes a high frequency signal modulated by a low frequency signal; means for measuring impedance of said tissue portion as a function of time while said electrical signal passes through said tissue portion; means for determining and storing a minimal value of tissue impedance while said electrical signal passes through said tissue portion; means for determining more than one ratio of said measured tissue portion impedance to said minimal value of tissue impedance while said electrical signal passes through said tissue portion after said impedance reaches its minimal value; and means for stopping said electrical signal from being passed through said tissue portion when said impedance ratio reaches a preset value, said preset value being specific for each bonded biological tissue.

Claim 36

Dependent Claim 176 words

Apparatus for bonding soft biological tissue having an incision therein, comprising: forceps adapted to grip a portion of the tissue on both sides of the incision; electrodes adapted to contact said tissue portion; an electrical power source for providing an electrical signal to said electrodes to be passed through said tissue portion, wherein said signal includes a high frequency signal modulated by a low frequency signal; means for measuring impedance of said tissue portion as a function of time while said electrical signal passes through said tissue portion; means for determining and storing a minimal value of tissue impedance while said electrical signal passes through said tissue portion; means for determining more than one ratio of said measured tissue portion impedance to said minimal value of tissue impedance while said electrical signal passes through said tissue portion after said impedance reaches its minimal value; and means for stopping said electrical signal from being passed through said tissue portion when said impedance ratio reaches a preset value, said preset value being specific for each bonded biological tissue.

Claim 37

Dependent Claim 48 words

The apparatus of claim 30 wherein the high frequency signal is in the range of 50 Kilohertz to 1 Megahertz, and further wherein said high frequency signal is modulated by the low frequency signal, said low frequency signal being in the rane of 4 Hertz to 6 Kilohertz.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2006-05-12	2006-11-11	2007-05-13	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2010-05-12	2010-11-11	2011-05-13	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2014-05-12	2014-11-11	2015-05-13	$7700.00	Window Closed / Lapsed

Bonding of soft biological tissues by passing high frequency electric current therethrough

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