US6579307B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Endovascular prosthesis having a layer of biological tissue
Assignee: Cleveland Clinic Foundation
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Filing: 2001-07-19
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Granted: 2003-06-17
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Expires: 2021-07-19
Abstract
Abstract An apparatus ( 10 ) for grafting of a blood vessel ( 12 ) and a method of forming the apparatus ( 10 ) is provided. The apparatus ( 10 ) comprises an expandable support member ( 16 ) having inner and outer surfaces ( 36 and 34 ). The outer surface ( 34 ) of the expandable support member ( 16 ) is for engaging and adhering to an inside surface ( 68 ) of the blood vessel ( 12 ). A layer of biological tissue ( 14 ) is attached to the inner surface ( 36 ) of the support member ( 16 ). The layer of biological tissue ( 14 ) has an uninterrupted inwardly facing surface ( 50 ) for extending confluently with the inside surface ( 68 ) of the blood vessel ( 12 ) to provide resistance to thrombosis and platelet deposition.
Inventors
- 👤 Timur Paul Sarac
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 23:18
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2/82; A61F2/86; A61F2/90; A61F2/91; A61L; A61L27/00; A61L27/50; A61L27/507; A61L31/00; A61L31/005; A61F2/062; A61F2002/075; A61F2220/00; A61F2220/0008
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
119 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: an expandable support member having inner and outer surfaces, said outer surface for engaging and adhering to the inside surface of the blood vessel; and a layer of biological tissue being attached to said inner surface of said support member, said layer of biological tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue being selected from a group consisting of peritoneal tissue and pleural tissue.
Claim 2
Independent Claim
119 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: an expandable support member having inner and outer surfaces, said outer surface for engaging and adhering to the inside surface of the blood vessel; and a layer of biological tissue being attached to said inner surface of said support member, said layer of biological tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue being selected from a group consisting of peritoneal tissue and pleural tissue.
Claim 3
Dependent Claim
19 words
The apparatus of claim 1 wherein said layer of biological tissue comprises an inner lining of a serous membrane.
Claim 4
Dependent Claim
14 words
The apparatus of claim 1 wherein said expandable support member comprises a fabric layer.
Claim 5
Dependent Claim
14 words
The apparatus of claim 1 wherein said expandable support member comprises a metallic stent.
Claim 6
Dependent Claim
15 words
The apparatus of claim 1 wherein said expandable support member comprises a layer of polytetraflouroethylene.
Claim 7
Dependent Claim
35 words
The apparatus of claim 1 wherein said expandable support member includes a plurality of eyelets for receiving a portion of a suture used for attaching said layer of biological tissue to said expandable support member.
Claim 8
Dependent Claim
18 words
The apparatus of claim 1 wherein said expandable support member includes a plurality of axially extending support rods.
Claim 9
Dependent Claim
46 words
The apparatus of claim 7 wherein said expandable support member further includes a plurality of eyelets for receiving a portion of a suture used for attaching said layer of biological tissue to said expandable support member, each eyelet being attached to an axially extending support rod.
Claim 10
Dependent Claim
17 words
The apparatus of claim 1 wherein said layer of biological tissue is provided by an autogenous graft.
Claim 11
Dependent Claim
17 words
The apparatus of claim 1 wherein said layer of biological tissue is provided by a cadaveric graft.
Claim 12
Dependent Claim
17 words
The apparatus of claim 1 wherein said layer of biological tissue is provided by a xenogeneic graft.
Claim 13
Dependent Claim
19 words
The apparatus of claim 1 wherein said layer of biological tissue forms a radially innermost component of said apparatus.
Claim 14
Dependent Claim
28 words
The apparatus of claim 12 wherein said layer of biological tissue includes first and second side surfaces, said first and second side surfaces abutting to form a seam.
Claim 15
Dependent Claim
38 words
The apparatus of claim 13 wherein said layer of biological tissue includes an inner surface and an outer surface, said outer surface of said layer of biological tissue being attached to said inner surface of said support member.
Claim 16
Dependent Claim
39 words
The apparatus of claim 14 wherein a layer of biological glue is applied over said outer surface of said layer of biological tissue at a location of said seam, said biological glue helping to prevent leakage through said seam.
Claim 17
Dependent Claim
19 words
The apparatus of claim 13 wherein said seam extends along an axial length of said layer of biological tissue.
Claim 18
Dependent Claim
80 words
A graft for a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said graft comprising a layer of biological tissue having an uninterrupted inwardly facing surface, said uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue being selected from a group consisting of peritoneum and pleura.
Claim 19
Dependent Claim
80 words
A graft for a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said graft comprising a layer of biological tissue having an uninterrupted inwardly facing surface, said uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue being selected from a group consisting of peritoneum and pleura.
Claim 20
Dependent Claim
34 words
The graft of claim 17 further including an expandable support member, said expandable support member having an outer surface and an inner surface, said inner surface engaging and supporting said layer of biological tissue.
Claim 21
Dependent Claim
31 words
The graft of claim 18 wherein said expandable support member forms an outermost portion of said graft and wherein said layer of biological tissue forms an innermost component of said graft.
Claim 22
Dependent Claim
26 words
The graft of claim 19 wherein said layer of biological tissue is provided by one of an autogenous graft, a cadaveric graft, and a xenogeneic graft.
Claim 23
Independent Claim
137 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: an expandable support member having inner and outer surfaces, said outer surface for engaging and adhering to the inside surface of the blood vessel; and a layer of biological tissue being attached to said inner surface of said support member, said layer of biological tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue comprising an inner lining of a serous membrane and an outer layer of associated fascia, said inner layer of serous membrane being supported by said outer lining of associated fascia.
Claim 24
Independent Claim
137 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: an expandable support member having inner and outer surfaces, said outer surface for engaging and adhering to the inside surface of the blood vessel; and a layer of biological tissue being attached to said inner surface of said support member, said layer of biological tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue comprising an inner lining of a serous membrane and an outer layer of associated fascia, said inner layer of serous membrane being supported by said outer lining of associated fascia.
Claim 25
Dependent Claim
24 words
The apparatus of claim 21 wherein said inner lining of a serous membrane is selected from the group consisting of peritoneum, pleura, and pericardium.
Claim 26
Independent Claim
141 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: an expandable support member having inner and outer surfaces, said outer surface for engaging and adhering to the inside surface of the blood vessel; and a layer of tissue being attached to said inner surface of said support member, said layer of tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of tissue being an artificial tissue that mimics the characteristics of biological tissue that is selected from the group consisting of peritoneum, pleura, and pericardium; said artificial tissue being constructed from collagen scaffolding that is seeded with tissue cells.
Claim 27
Independent Claim
141 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: an expandable support member having inner and outer surfaces, said outer surface for engaging and adhering to the inside surface of the blood vessel; and a layer of tissue being attached to said inner surface of said support member, said layer of tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of tissue being an artificial tissue that mimics the characteristics of biological tissue that is selected from the group consisting of peritoneum, pleura, and pericardium; said artificial tissue being constructed from collagen scaffolding that is seeded with tissue cells.
Claim 28
Dependent Claim
12 words
The apparatus of claim 23 wherein said tissue cells comprise human keratinocytes.
Claim 29
Dependent Claim
15 words
The apparatus of claim 23 wherein said layer of tissue also includes a basement membrane.
Claim 30
Dependent Claim
18 words
The apparatus of claim 25 wherein said basement membrane is a fascia lining for supporting the collagen scaffolding.
Claim 31
Independent Claim
153 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: a support member having first and second surfaces, one of said first and second surfaces for engaging and adhering to the inside surface of the blood vessel; and a layer of biological tissue being attached to the other of said first and second surfaces of said support member, said layer of biological tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue being selected from the group consisting of peritoneum, pleura, and pericardium; said layer of biological tissue including a serous membrane lining and an associated fascia lining, said serous membrane lining forming a radially innermost component of said apparatus.
Claim 32
Independent Claim
153 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: a support member having first and second surfaces, one of said first and second surfaces for engaging and adhering to the inside surface of the blood vessel; and a layer of biological tissue being attached to the other of said first and second surfaces of said support member, said layer of biological tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue being selected from the group consisting of peritoneum, pleura, and pericardium; said layer of biological tissue including a serous membrane lining and an associated fascia lining, said serous membrane lining forming a radially innermost component of said apparatus.
Claim 33
Dependent Claim
46 words
The apparatus of claim 27 wherein said layer of biological tissue includes first and second side surfaces that are abutted to form a seam, said layer of biological tissue having a tubular shape when said first and second side surfaces are abutted to form said seam.
Claim 34
Independent Claim
175 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: a support member having first and second surfaces, one of said first and second surfaces for engaging and adhering to the inside surface of the blood vessel; and a layer of biological tissue being attached to the other of said first and second surfaces of said support member, said layer of biological tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue being selected from the group consisting of peritoneum, pleura, and pericardium; said layer of biological tissue including a serous membrane lining; said support member including an outer frame and inner support beams, said outer frame supporting a peripheral portion of said layer of biological tissue and said inner support beams supporting an interior portion of said layer of biological tissue.
Claim 35
Independent Claim
175 words
An apparatus for grafting of a blood vessel, the blood vessel having an inside surface that defines a conduit for directing blood flow, said apparatus comprising: a support member having first and second surfaces, one of said first and second surfaces for engaging and adhering to the inside surface of the blood vessel; and a layer of biological tissue being attached to the other of said first and second surfaces of said support member, said layer of biological tissue having an uninterrupted inwardly facing surface for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit; said layer of biological tissue being selected from the group consisting of peritoneum, pleura, and pericardium; said layer of biological tissue including a serous membrane lining; said support member including an outer frame and inner support beams, said outer frame supporting a peripheral portion of said layer of biological tissue and said inner support beams supporting an interior portion of said layer of biological tissue.
Claim 36
Dependent Claim
24 words
The apparatus of claim 29 wherein said outer frame has a shape that is similar to a shape of said layer of biological tissue.
Claim 37
Dependent Claim
91 words
A graft for a blood vessel, the blood vessel having an inside surface that at least partially defines a conduit for directing blood flow, said graft comprising a layer of biological tissue having an uninterrupted inwardly facing surface, said uninterrupted inwardly facing surface for at least partially defining the conduit and for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit, said layer of biological tissue being selected from a group consisting of peritoneum and pleura.
Claim 38
Dependent Claim
91 words
A graft for a blood vessel, the blood vessel having an inside surface that at least partially defines a conduit for directing blood flow, said graft comprising a layer of biological tissue having an uninterrupted inwardly facing surface, said uninterrupted inwardly facing surface for at least partially defining the conduit and for extending confluently with the inside surface of the blood vessel to provide resistance to thrombosis and platelet deposition as blood flows through the conduit, said layer of biological tissue being selected from a group consisting of peritoneum and pleura.
Claim 39
Dependent Claim
21 words
The graft of claim 31 wherein said uninterrupted inwardly facing surface of said layer of biological tissue has a cylindrical shape.
Claim 40
Dependent Claim
20 words
The graft of claim 31 wherein said uninterrupted surface of said layer of biological tissue has a partially cylindrical shape.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-06-16 | 2006-12-16 | 2007-06-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-06-16 | 2010-12-16 | 2011-06-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-06-16 | 2014-12-16 | 2015-06-17 | $7700.00 | Window Closed / Lapsed |