US6602261B2
Expired / Lapsed
US
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Filamentous embolic device with expansile elements
Assignee: MicroVention Inc
•
Filing: 2001-05-29
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Granted: 2003-08-05
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Expires: 2021-05-29
Abstract
Abstract An embolization device includes one or more expansible, hydrophilic embolizing elements non-releasably carried along the length of a filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In a second embodiment, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip. In either of the embodiments, the embolizing elements may be made of a hydrophilic, macroporous, polymeric, hydrogel foam material. In the second embodiment, the elongate embolizing element is preferably made of a porous, environmentally-sensitive, expansile hydrogel that expands, after a predetermined time delay, in response to a change in an environmental parameter, such as pH or temperature.
Inventors
- 👤 George R. Greene, Jr.
- 👤 Gregory M. Cruise
- 👤 Michael Constant
- 👤 Brian J. Cox
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 20:42
CPC Classifications
B; B29; B29C; B29C70/00; B29C70/68; B29C70/74; A; A61; A61B; A61B17/00; A61B17/12; A61B17/12022; A61B17/12099; A61B17/12109; A61B17/12113; A61B17/12118; A61B17/12131; A61B17/1214; A61B17/12145; A61B17/1215; A61B17/12154; A61B17/12163; A61B17/12181; A61B17/1219; A61L; A61L31/00; A61L31/02; A61L31/022; A61L31/14; A61L31/145; A61L31/18; A61B2017/00004; A61B2017/1205; A61L2430/00; A61L2430/36; B29L; B29L2031/00; B29L2031/753; B29L2031/7542
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
53 words
A vascular embolization device, comprising: an elongate, flexible, filamentous carrier; and an embolizing element non-releasably fixed to the carrier, the embolizing element being formed from an expansile polymer that expands in response to a change in an environmental parameter selected from the group consisting of temperature and pH after a predetermined time interval.
Claim 2
Dependent Claim
53 words
A vascular embolization device, comprising: an elongate, flexible, filamentous carrier; and an embolizing element non-releasably fixed to the carrier, the embolizing element being formed from an expansile polymer that expands in response to a change in an environmental parameter selected from the group consisting of temperature and pH after a predetermined time interval.
Claim 3
Dependent Claim
14 words
The embolization device of claim 1 , wherein the polymer is a porous hydrogel.
Claim 4
Dependent Claim
37 words
The embolization device of claim 1 , wherein the embolizing element comprises an elongate, continuous, coaxial embolyzing element non-releasably fixed to the exterior surface of the carrier along a substantial portion of the length of the carrier.
Claim 5
Dependent Claim
22 words
The embolization device of claim 1 , wherein the embolizing element comprises a plurality of expansile polymer fibers attached to the carrier.
Claim 6
Dependent Claim
13 words
The embolization device of claim 1 , wherein the embolizing element is radiopaque.
Claim 7
Dependent Claim
27 words
The embolization device of claim 1 , wherein the carrier is configured in the form of a multi-looped structure that may assume a three-dimensional shape when unconstrained.
Claim 8
Dependent Claim
25 words
The embolization device of claim 6 , wherein the three-dimensional shape is selected from the group consisting of a sphere, a helix, and an ovoid.
Claim 9
Dependent Claim
41 words
A vascular embolization device, comprising: an elongate, flexible, filamentous carrier of predetermined length; and a plurality of expansile fibers fixed to the carrier at spaced intervals along the length of the carrier, the fibers being formed from an expansile polymer hydrogel.
Claim 10
Dependent Claim
41 words
A vascular embolization device, comprising: an elongate, flexible, filamentous carrier of predetermined length; and a plurality of expansile fibers fixed to the carrier at spaced intervals along the length of the carrier, the fibers being formed from an expansile polymer hydrogel.
Claim 11
Dependent Claim
40 words
The embolization device of claim 8 , wherein the polymer hydrogel is of a type that expands in response to a change in an environmental parameter selected from the group consisting of temperature and pH after a predetermined time interval.
Claim 12
Dependent Claim
27 words
The embolization device of claim 8 , wherein the carrier is configured in the form of a multi-looped structure that may assume a three-dimensional shape when unconstrained.
Claim 13
Dependent Claim
25 words
The embolization device of claim 10 , wherein the three-dimensional shape is selected from the group consisting of a sphere, a helix, and an ovoid.
Claim 14
Dependent Claim
79 words
A vascular embolization device, comprising: a flexible, filamentous carrier having an exterior surface and a distal tip; and an expansile embolizing element non-releasably fixed coaxially to the exterior surface of the carrier at a location proximal from the distal tip, wherein the embolizing element is formed of an expansile, hydrophilic polymer that changes its physical character in response to a change in an environmental parameter selected from the group consisting of pH and temperature after a predetermined time interval.
Claim 15
Dependent Claim
79 words
A vascular embolization device, comprising: a flexible, filamentous carrier having an exterior surface and a distal tip; and an expansile embolizing element non-releasably fixed coaxially to the exterior surface of the carrier at a location proximal from the distal tip, wherein the embolizing element is formed of an expansile, hydrophilic polymer that changes its physical character in response to a change in an environmental parameter selected from the group consisting of pH and temperature after a predetermined time interval.
Claim 16
Dependent Claim
19 words
The device of claim 12 , wherein the carrier is formed of a flexible material having an elastic memory.
Claim 17
Dependent Claim
54 words
The device of claim 12 , wherein the embolizing element is a first embolizing element fixed to the carrier at a cation, and wherein the device further comprises at least a second expansile embolizing element non-releasably fixed coaxially to the exterior surface of the carrier at a second location proximal from the distal tip.
Claim 18
Dependent Claim
26 words
The device of claim 12 , wherein the carrier is configured in the form of a multi-looped structure that may assume a three-dimensional shape when unconstrained.
Claim 19
Dependent Claim
24 words
The device of claim 15 , wherein the three-dimensional shape is selected from the group consisting of a sphere, a helix, and an ovoid.
Claim 20
Dependent Claim
17 words
The device of claim 12 , wherein the embolizing element is formed of a strectch-resistant, biocompatible polymer.
Claim 21
Dependent Claim
23 words
The device of claim 12 , wherein the embolizing element is expansible by a volumetric expansion factor of about 2× to about 100×.
Claim 22
Dependent Claim
13 words
The device of claim 12 , wherein the polymer is a porous hydrogel.
Claim 23
Dependent Claim
104 words
A vascular embolization device that is deployable intravascularly while attached to a deployment instrument having a distal end, the embolization device comprising: a flexible filamentous carrier having proximal and distal ends; an embolizing element coaxially covering a substantial portion of the length of the carrier between the proximal and distal ends thereof, the embolizing element being formed of an expansile hydrophilic polymer that expands in response to a change in an environmental parameter; and a linkage element formed of an expansile hydrogel, located on the proximal end of the carrier, that releasably attaches the embolizatlon device to the distal end of the deployment instrument.
Claim 24
Dependent Claim
104 words
A vascular embolization device that is deployable intravascularly while attached to a deployment instrument having a distal end, the embolization device comprising: a flexible filamentous carrier having proximal and distal ends; an embolizing element coaxially covering a substantial portion of the length of the carrier between the proximal and distal ends thereof, the embolizing element being formed of an expansile hydrophilic polymer that expands in response to a change in an environmental parameter; and a linkage element formed of an expansile hydrogel, located on the proximal end of the carrier, that releasably attaches the embolizatlon device to the distal end of the deployment instrument.
Claim 25
Dependent Claim
99 words
A vascular embolization device that is deployable intravascularly while attached to a deployment instrument having a distal end, the embolization device comprising: a flexible filamentous carrier having proximal and distal ends; an embolizing element coaxially covering a substantial portion of the length of the carrier between the proximal and distal ends thereof, the embolizing element being formed of a stretch-resistant, expansile hydrophilic polymer that expands in response to a change in an environmental parameter; and a linkage element on the proximal end of the carrier that releasably attaches the embolization device to the distal end of the deployment instrument.
Claim 26
Dependent Claim
99 words
A vascular embolization device that is deployable intravascularly while attached to a deployment instrument having a distal end, the embolization device comprising: a flexible filamentous carrier having proximal and distal ends; an embolizing element coaxially covering a substantial portion of the length of the carrier between the proximal and distal ends thereof, the embolizing element being formed of a stretch-resistant, expansile hydrophilic polymer that expands in response to a change in an environmental parameter; and a linkage element on the proximal end of the carrier that releasably attaches the embolization device to the distal end of the deployment instrument.
Claim 27
Dependent Claim
18 words
The embolization device of claim 21 , wherein the carrier comprises a material that is visible under X-rays.
Claim 28
Dependent Claim
37 words
The embolization device of claim 21 , wherein the polymer is an environmentally-sensitive polymer that changes its physical character in response to a change in an environmental parameter selected from the group consisting of temperature and pH.
Claim 29
Dependent Claim
25 words
The embolization device of claim 21 , wherein the embolizing element is expansible by a volumetric expansion factor of between about 2× and about 100×.
Claim 30
Dependent Claim
13 words
The embolization device of claim 21 , wherein the embolizing element is radiopaque.
Claim 31
Dependent Claim
27 words
The embolization device of claim 21 , wherein the carrier is configured in the form of a multi-looped structure that may assume a three-dimensional shape when unconstrained.
Claim 32
Dependent Claim
25 words
The embolization device of claim 26 , wherein the three-dimensional shape is selected from the group consisting of a sphere, a helix, and an ovoid.
Claim 33
Dependent Claim
107 words
A vascular embolization device that is deployable intravascularly while attached to a deployment instrument having a distal end, the embolization device comprising: a flexible filamentous carrier having proximal and distal ends; an embolizing element coaxially covering a substantial portion of the length of the carrier between the proximal and distal ends thereof, the embolizing element being formed of an expansile hydrophilic polymer that expands In response to a change in an environmental parameter selected from the group consisting of temperature and pH; and a linkage element on the proximal end of the carrier that releasably attaches the embolization device to the distal end of the deployment instrument.
Claim 34
Dependent Claim
107 words
A vascular embolization device that is deployable intravascularly while attached to a deployment instrument having a distal end, the embolization device comprising: a flexible filamentous carrier having proximal and distal ends; an embolizing element coaxially covering a substantial portion of the length of the carrier between the proximal and distal ends thereof, the embolizing element being formed of an expansile hydrophilic polymer that expands In response to a change in an environmental parameter selected from the group consisting of temperature and pH; and a linkage element on the proximal end of the carrier that releasably attaches the embolization device to the distal end of the deployment instrument.
Claim 35
Dependent Claim
12 words
The embolization device of claim 28 , wherein the polymer is stretch-resistant.
Claim 36
Dependent Claim
18 words
The embolization device of claim 28 , wherein the carrier comprises a material that is visible under X-rays.
Claim 37
Dependent Claim
25 words
The embolization device of claim 28 , wherein the embolizing element is expansible by a volumetric expansion factor of between about 2× and about 100×.
Claim 38
Dependent Claim
13 words
The embolization device of claim 28 , wherein the embolizing element is radiopaque.
Claim 39
Dependent Claim
27 words
The embolization device of claim 28 , wherein the carrier is configured in the form of a multi-looped structure that may assume a three-dimensional shape when unconstrained.
Claim 40
Dependent Claim
25 words
The embolization device of claim 33 , wherein the three-dimensional shape is selected from the group consisting of a sphere, a helix, and an ovoid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-08-04 | 2007-02-03 | 2007-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-08-04 | 2011-02-03 | 2011-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-08-04 | 2015-02-03 | 2015-08-05 | $7700.00 | Window Closed / Lapsed |