US6656206B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Occlusion device with non-thrombogenic properties
Assignee: Cardia Inc
•
Filing: 2002-01-23
•
Granted: 2003-12-02
•
Expires: 2022-01-23
Abstract
Abstract A method of forming a PVA foam structure for use in an occlusion device such that the PVA foam structure comprises non-thrombogenic properties. The method comprises forming a PVA gel and incorporating heparin into the PVA gel. The PVA foam structure is then treated with the PVA gel and heparin mixture, such as by soaking the PVA foam structure in the gel.
Inventors
- 👤 Michael P. Corcoran
- 👤 Peter M. Buonomo
- 👤 Joseph A. Marino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 06:25
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/12; A61L31/125; A61L31/129; A61B; A61B17/00; A61B17/0057; A61B17/12; A61B17/12022; A61B17/12099; A61B17/12122; A61B17/12131; A61B17/12168; A61B17/12172; A61L31/14; A61L31/146; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L33/007; A61L33/06; A61L33/064; A61B2017/00526; A61B2017/00575; A61B2017/00592; A61B2017/00606; A61B2017/1205; A61L2430/00; A61L2430/36
Claims Analysis
Total Claims: 45
Claim 1
Independent Claim
55 words
A method of creating a non-thrombogenic polyvinyl alcohol foam structure for use in an occlusion device, the method comprising: forming a structure from polyvinyl alcohol foam; applying a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol to the polyvinyl alcohol foam structure; and attaching the foam structure to an occlusion device.
Claim 2
Independent Claim
55 words
A method of creating a non-thrombogenic polyvinyl alcohol foam structure for use in an occlusion device, the method comprising: forming a structure from polyvinyl alcohol foam; applying a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol to the polyvinyl alcohol foam structure; and attaching the foam structure to an occlusion device.
Claim 3
Dependent Claim
26 words
The method of claim 1 wherein forming a structure from polyvinyl alcohol foam comprises cutting the polyvinyl alcohol foam to obtain a polyvinyl alcohol foam sheet.
Claim 4
Dependent Claim
22 words
The method of claim 1 wherein the mixture of polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol comprises a gel.
Claim 5
Dependent Claim
23 words
The method of claim 3 and further comprising rinsing the polyvinyl alcohol foam structure after the structure has been soaked in the gel.
Claim 6
Dependent Claim
27 words
The method of claim 3 wherein applying the gel to the polyvinyl alcohol foam structure comprises soaking the foam structure in the gel for about five minutes.
Claim 7
Independent Claim
59 words
A method of forming a polyvinyl alcohol foam structure having non-thrombogenic properties for use in an occlusion device, the method comprising: creating a polyvinyl alcohol mixture comprising polyvinyl alcohol and heparin bonded to the polyvinyl alcohol; applying the polyvinyl alcohol heparin mixture to the polyvinyl alcohol foam structure; and attaching the polyvinyl alcohol foam structure to an occlusion device.
Claim 8
Independent Claim
59 words
A method of forming a polyvinyl alcohol foam structure having non-thrombogenic properties for use in an occlusion device, the method comprising: creating a polyvinyl alcohol mixture comprising polyvinyl alcohol and heparin bonded to the polyvinyl alcohol; applying the polyvinyl alcohol heparin mixture to the polyvinyl alcohol foam structure; and attaching the polyvinyl alcohol foam structure to an occlusion device.
Claim 9
Dependent Claim
35 words
The method of claim 6 wherein creating a polyvinyl alcohol mixture comprising polyvinyl alcohol and heparin bonded to the polyvinyl alcohol comprises: creating a polyvinyl alcohol gel; and adding heparin to the polyvinyl alcohol gel.
Claim 10
Dependent Claim
29 words
The method of claim 7 wherein adding the heparin to the polyvinyl alcohol gel further comprising utilizing a catalyst to assist the heparin in bonding to the polyvinyl alcohol.
Claim 11
Dependent Claim
25 words
The method of claim 7 and further comprising applying heat to the polyvinyl alcohol gel to assist the heparin in bonding to the polyvinyl alcohol.
Claim 12
Dependent Claim
20 words
The method of claim 7 and further comprising obtaining a foam structure from a larger amount of polyvinyl alcohol foam.
Claim 13
Dependent Claim
25 words
The method of claim 10 wherein obtaining a foam structure comprises obtaining a sheet of polyvinyl alcohol foam from a block of polyvinyl alcohol foam.
Claim 14
Dependent Claim
29 words
The method of claim 11 wherein applying the polyvinyl alcohol gel to the polyvinyl alcohol foam structure comprises soaking the polyvinyl alcohol foam sheet in the polyvinyl alcohol gel.
Claim 15
Dependent Claim
22 words
The method of claim 12 wherein the polyvinyl alcohol foam sheet is soaked in the polyvinyl alcohol gel for about five minutes.
Claim 16
Dependent Claim
24 words
The method of claim 13 and further comprising rinsing the polyvinyl alcohol foam sheet after applying the polyvinyl alcohol gel to the foam sheet.
Claim 17
Dependent Claim
26 words
The method of claim 14 wherein rinsing the polyvinyl alcohol foam sheet comprises rinsing the foam sheet with buffered saline and allowing the sheet to dry.
Claim 18
Dependent Claim
43 words
An occlusion device comprising a polyvinyl alcohol foam structure having non-thrombogenic properties, the polyvinyl alcohol foam structure comprising: a polyvinyl alcohol foam substrate; a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol applied to the polyvinyl alcohol foam substrate.
Claim 19
Dependent Claim
43 words
An occlusion device comprising a polyvinyl alcohol foam structure having non-thrombogenic properties, the polyvinyl alcohol foam structure comprising: a polyvinyl alcohol foam substrate; a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol applied to the polyvinyl alcohol foam substrate.
Claim 20
Dependent Claim
17 words
The polyvinyl alcohol foam structure of claim 16 wherein the mixture comprises a polyvinyl alcohol heparin gel.
Claim 21
Dependent Claim
70 words
An occlusion device, the device comprising: a center section extending in an axial direction; upper and lower elastic shape memory fixation devices emanating from the center section; and first and second foam sheets attached to the upper and lower fixation devices, respectively, wherein the foam sheets are formed of polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 22
Dependent Claim
70 words
An occlusion device, the device comprising: a center section extending in an axial direction; upper and lower elastic shape memory fixation devices emanating from the center section; and first and second foam sheets attached to the upper and lower fixation devices, respectively, wherein the foam sheets are formed of polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 23
Dependent Claim
74 words
An occlusion device for the closure of a physical anomaly, the device comprising: a support structure including a center section and first and second flexible arms extending outward from the center section; and a first foam sheet attached to the first flexible arm, wherein the first foam sheet is formed of polyvinyl alcohol foam which has been treated with a polyvinyl alcohol gel comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 24
Dependent Claim
74 words
An occlusion device for the closure of a physical anomaly, the device comprising: a support structure including a center section and first and second flexible arms extending outward from the center section; and a first foam sheet attached to the first flexible arm, wherein the first foam sheet is formed of polyvinyl alcohol foam which has been treated with a polyvinyl alcohol gel comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 25
Dependent Claim
50 words
The occlusion device in claim 19 and further comprising a second foam sheet attached to the second flexible arm, wherein the second foam sheet is formed of polyvinyl alcohol foam which has been treated with a polyvinyl alcohol gel comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 26
Dependent Claim
79 words
An occlusion device, the device comprising: a center strut; a first plurality of fixation devices extending from a first end of the center strut; a first sheet attached to the first plurality of fixation devices, wherein the first sheet is formed of polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol; and a second plurality of fixation devices extending from a second end of the center strut.
Claim 27
Dependent Claim
79 words
An occlusion device, the device comprising: a center strut; a first plurality of fixation devices extending from a first end of the center strut; a first sheet attached to the first plurality of fixation devices, wherein the first sheet is formed of polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol; and a second plurality of fixation devices extending from a second end of the center strut.
Claim 28
Dependent Claim
48 words
The occlusion device of claim 21 and further comprising a second sheet attached to the second plurality of fixation devices, wherein the second sheet is formed of polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 29
Dependent Claim
130 words
An occlusion device, the device comprising: a center strut having distal and proximal ends; a first set of stranded wire support arms extending from the distal end of the center strut; a first sheet attached to the first set of arms, wherein the first sheet is formed from polyvinyl alcohol foam which has been treated with a polyvinyl alcohol gel comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol; a second set of stranded wire support arms extending from the proximal end of the center strut; and a second sheet attached to the second set of support arms, wherein the second sheet is formed from polyvinyl alcohol foam which has been treated with a polyvinyl alcohol gel comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 30
Dependent Claim
130 words
An occlusion device, the device comprising: a center strut having distal and proximal ends; a first set of stranded wire support arms extending from the distal end of the center strut; a first sheet attached to the first set of arms, wherein the first sheet is formed from polyvinyl alcohol foam which has been treated with a polyvinyl alcohol gel comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol; a second set of stranded wire support arms extending from the proximal end of the center strut; and a second sheet attached to the second set of support arms, wherein the second sheet is formed from polyvinyl alcohol foam which has been treated with a polyvinyl alcohol gel comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 31
Dependent Claim
89 words
An occlusion device for the closure of a physical anomaly, the occlusion device comprising: a center piece extending in an axial direction; first and second collapsible support frames spaced from one another and emanating from the center piece, the support frames being formed by multiwire strands; and first and second foam sheets attached to the first and second collapsible support frames, respectively, wherein the sheets are formed from polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 32
Dependent Claim
89 words
An occlusion device for the closure of a physical anomaly, the occlusion device comprising: a center piece extending in an axial direction; first and second collapsible support frames spaced from one another and emanating from the center piece, the support frames being formed by multiwire strands; and first and second foam sheets attached to the first and second collapsible support frames, respectively, wherein the sheets are formed from polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 33
Dependent Claim
111 words
An occlusion device, the device comprising: a first collapsible support frame; a second collapsible support frame, the second collapsible support frame being spaced from and connected to the first collapsible support frame; a first sheet attached to the first collapsible support frame, wherein the first sheet is formed from polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol; and a second polyvinyl alcohol sheet attached to the second collapsible support frame, wherein the second sheet is formed from polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 34
Dependent Claim
111 words
An occlusion device, the device comprising: a first collapsible support frame; a second collapsible support frame, the second collapsible support frame being spaced from and connected to the first collapsible support frame; a first sheet attached to the first collapsible support frame, wherein the first sheet is formed from polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol; and a second polyvinyl alcohol sheet attached to the second collapsible support frame, wherein the second sheet is formed from polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 35
Dependent Claim
49 words
An occlusion device, the device comprising: a support structure; and a polyvinyl alcohol foam occlusion member attached to the support structure wherein the occlusion member is formed from polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 36
Dependent Claim
49 words
An occlusion device, the device comprising: a support structure; and a polyvinyl alcohol foam occlusion member attached to the support structure wherein the occlusion member is formed from polyvinyl alcohol foam which has been treated with a mixture comprising polyvinyl alcohol and heparin chemically bonded to the polyvinyl alcohol.
Claim 37
Independent Claim
55 words
A method of creating foam sheets for use in an occlusion device wherein the foam sheets have non-thrombogenic properties, the method comprising: providing polyvinyl alcohol foam; slicing the foam into sheets of a desired size; dipping the foam sheets into a solution comprising a thrombosis inhibitor; and attaching the foam sheets to an occlusion device.
Claim 38
Independent Claim
55 words
A method of creating foam sheets for use in an occlusion device wherein the foam sheets have non-thrombogenic properties, the method comprising: providing polyvinyl alcohol foam; slicing the foam into sheets of a desired size; dipping the foam sheets into a solution comprising a thrombosis inhibitor; and attaching the foam sheets to an occlusion device.
Claim 39
Dependent Claim
11 words
The method of claim 27 wherein the thrombosis inhibitor is heparin.
Claim 40
Dependent Claim
22 words
The method of claim 27 wherein the solution comprises a chemical fixative to aid in keeping the heparin on the foam sheets.
Claim 41
Dependent Claim
19 words
The method of claim 27 and further comprising preparing a surface of the foam sheets to accept the heparin.
Claim 42
Dependent Claim
22 words
The method of claim 30 wherein preparing the surface of the foam sheets comprises plasma etching the surfaces of the foam sheets.
Claim 43
Independent Claim
47 words
A method of creating foam with non-thrombogenic properties for use in an occlusion device, the method comprising: forming a mixture of polyvinyl alcohol and heparin in a liquid state; forming a foam of the polyvinyl alcohol and heparin mixture; and attaching the foam to an occlusion device.
Claim 44
Independent Claim
47 words
A method of creating foam with non-thrombogenic properties for use in an occlusion device, the method comprising: forming a mixture of polyvinyl alcohol and heparin in a liquid state; forming a foam of the polyvinyl alcohol and heparin mixture; and attaching the foam to an occlusion device.
Claim 45
Dependent Claim
15 words
The method of claim 32 and further comprising slicing the foam into sheets 18 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2006-12-01 | 2007-06-02 | 2007-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-12-01 | 2011-06-02 | 2011-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-12-01 | 2015-06-02 | 2015-12-02 | $7700.00 | Window Closed / Lapsed |