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US7662829B2
Active / In Force
US
⏱️ 1.3 years remaining
Methods, compositions, and kits for organ protection during systemic anticancer therapy
Assignee: Asymmetric Therapeutics LLC
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Filing: 2008-03-05
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Granted: 2010-02-16
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Expires: 2028-03-05
Abstract
Abstract Methods, compositions, and kits are presented for local tissue protection during systemic administration of anticancer therapeutic agents.
Inventors
- 👤 John P. Ford
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 09:50
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/513; A61K31/335; A61K31/337; A61K31/555; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61K31/7042; A61K31/7052; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7072; A61P; A61P17/00; A61P39/00; A61P43/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
88 words
A method of protecting skin surfaces of a human in need thereof from the undesirable side-effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof without abrogating the clinical efficacy of said systemically distributed anticancer therapeutic agent or metabolite, comprising: administering a formulation comprising uracil to the skin surfaces in an amount that is effective to protect against the undesirable side-effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof.
Claim 2
Independent Claim
88 words
A method of protecting skin surfaces of a human in need thereof from the undesirable side-effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof without abrogating the clinical efficacy of said systemically distributed anticancer therapeutic agent or metabolite, comprising: administering a formulation comprising uracil to the skin surfaces in an amount that is effective to protect against the undesirable side-effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof.
Claim 3
Dependent Claim
14 words
The method of claim 1 , wherein the skin surface is the palmar surface.
Claim 4
Dependent Claim
14 words
The method of claim 1 , wherein the skin surface is the plantar surface.
Claim 5
Dependent Claim
50 words
The method of claim 1 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.01 wt. % to about 20 wt. %.
Claim 6
Dependent Claim
49 words
The method of claim 1 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.01 wt.% to about 10 wt. %.
Claim 7
Dependent Claim
50 words
The method of claim 1 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.01 wt. % to about 5 wt. %.
Claim 8
Dependent Claim
45 words
The method of claim 1 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.01 wt. %.
Claim 9
Dependent Claim
40 words
The method of claim 1 , wherein the concentration of uracil effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.1 wt. %.
Claim 10
Dependent Claim
40 words
The method of claim 1 , wherein the concentration of uracil effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 1 wt. %.
Claim 11
Independent Claim
92 words
A method of protecting palmar and plantar surfaces of a human in need thereof from the undesirable side-effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof without abrogating the clinical efficacy of said systemically distributed anticancer therapeutic agent or metabolite, comprising: administering a formulation comprising uracil to the palmar and plantar surfaces in an amount that is effective to protect against the undesirable side-effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof.
Claim 12
Independent Claim
92 words
A method of protecting palmar and plantar surfaces of a human in need thereof from the undesirable side-effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof without abrogating the clinical efficacy of said systemically distributed anticancer therapeutic agent or metabolite, comprising: administering a formulation comprising uracil to the palmar and plantar surfaces in an amount that is effective to protect against the undesirable side-effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof.
Claim 13
Dependent Claim
50 words
The method of claim 10 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.01 wt. % to about 20 wt. %.
Claim 14
Dependent Claim
50 words
The method of claim 10 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.01 wt. % to about 10 wt. %.
Claim 15
Dependent Claim
50 words
The method of claim 10 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.01 wt. % to about 5 wt. %.
Claim 16
Dependent Claim
45 words
The method of claim 10 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.01 wt. %.
Claim 17
Dependent Claim
45 words
The method of claim 10 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 0.1 wt. %.
Claim 18
Dependent Claim
45 words
The method of claim 10 , wherein the concentration of uracil in the formulation that is effective to protect against the effects of one or more systemically distributed anticancer therapeutic agents or metabolites comprised of 5-fluorouracil or a prodrug thereof is about 1 wt. %.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2013-02-15 | 2013-08-17 | 2014-02-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2017-02-15 | 2017-08-17 | 2018-02-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2021-02-15 | 2021-08-17 | 2022-02-16 | $7700.00 | Window Closed / Lapsed |