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EP0040472A2
Expired / Lapsed
EP
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Spray dried N-acetyl-p-aminophenol compositions and method for manufacture thereof
Assignee: Mallinckrodt Inc
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Filing: 1981-04-16
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Granted: —
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Expires: 2001-04-16
Abstract
Abstract Spray dried compositions are disclosed comprising agglomerates of N-acetyl-p-aminophenol in a gelatinized starch matrix; said compositions prepared by spray drying a slurry including N-acetyl-p-aminophenol and gelatinized starch and optionally including other active ingredients such as codeine salts; said spray dried compositions having good compressibility and flow properties facilitating the formation of tablets, capsules and other dosage forms.
Inventors
- 👤 Anil M. Salpekar
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-31 05:55
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2059; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
63 words
A method for preparing a spray dried N-acetyl-p-aminophenol composition, said method comprising: (a) forming a slurry of finely divided N-acetyl-p-aminophenol and starch; (b) spray drying said slurry under spray drying conditions such that the spray dried particles have a moisture content between 0.3 and 1.5 percent by weight, said starch being gelatinized either prior to said spray drying step or during said step.
Claim 2
Independent Claim
63 words
A method for preparing a spray dried N-acetyl-p-aminophenol composition, said method comprising: (a) forming a slurry of finely divided N-acetyl-p-aminophenol and starch; (b) spray drying said slurry under spray drying conditions such that the spray dried particles have a moisture content between 0.3 and 1.5 percent by weight, said starch being gelatinized either prior to said spray drying step or during said step.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein the gelatinized starch comprises 7 to 12 percent by weight of said composition.
Claim 4
Dependent Claim
42 words
The method of claim 1 or claim 2 wherein the slurry contains no more than 60 percent by weight solids and wherein said solids comprise 98.5 to 75 percent by weight of N-acetyl-p-aminophenol and 1.5 to 25 percent by weight of starch.
Claim 5
Independent Claim
22 words
The method of any one of claims 1 to 3 wherein another compatible active ingredient is substituted for part of the N-acetyl-p-aminophenol.
Claim 6
Dependent Claim
15 words
The method of claim 4 wherein the active ingredient is an alkaloid or salt thereof.
Claim 7
Dependent Claim
14 words
6 . The method of claim 5 wherein the alkaloid salt is codeine phosphate.
Claim 8
Independent Claim
35 words
The method of any one of claims 1 to 6 wherein 100 percent of the finely divided N-acetyl-p-aminophenol will pass through a 200 mesh screen and 75 percent will pass through a 325 mesh screen.
Claim 9
Independent Claim
17 words
The method of any one of claims 1 to 7 wherein the gelatinized starch is pregelatinized starch.
Claim 10
Independent Claim
33 words
The method of any one of claims 1 to 8 wherein at least 80 percent of the spray dried particles are coarser than 200 mesh, while 95 percent are finer than 40 mesh.
Claim 11
Dependent Claim
28 words
A composition comprising spray dried particles of N-acetyl-p-aminophenol in a starch matrix wherein the moisture content is between 0.3 and 1.5 percent by weight, said starch being gelatinized.
Claim 12
Dependent Claim
28 words
A composition comprising spray dried particles of N-acetyl-p-aminophenol in a starch matrix wherein the moisture content is between 0.3 and 1.5 percent by weight, said starch being gelatinized.
Claim 13
Dependent Claim
21 words
The composition of claim 10 wherein the gelatinized starch comprises between 1.5 and 25 percent by weight of the solids content.
Claim 14
Dependent Claim
20 words
The composition of claim 10 or claim 11 wherein another compatible active ingredient is substituted for part of the N-acetyl-p-aminophenol.
Claim 15
Dependent Claim
15 words
The composition of claim 12 wherein the active ingredient is an alkaloid or salt thereof.
Claim 16
Dependent Claim
12 words
The composition of claim 13 wherein the alkaloid salt is codeine phosphate.
References Cited (Backward Citations)
No citation records indexed.
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