7-Amino-1-cyclopropyl-4-oxo-1,4-dihydro-(naphthyridine or quinoline)-3-carboxylic acids, process for their preparation and pharmaceutical compositions containing them

Claim 1

7-Amino-1-cyclopropyl-4-oxo-1 A-diphydro-naphthyridine-3-carboxylic acids of the general formula I in which A can be nitrogen or CR 3 wherein R 3 can be hydrogen, nitro, halogen, preferably fluorine or chlorine, or a nitrile, carboxamide, carboxyl or ester group, and B represents nitrogen or C- H, and A and B cannot simultaneously be nitrogen, and R 1 and R 2 are identical or different and represent hydrogen or a branched or straight-chain alkyl, alkenyl or alkinyl radical which has 1-12 carbon atoms and can optionally be substituted by hydroxyl groups, alkoxy, alkylmercapto or dialkylamino groups with 1-3 carbon atoms in each alkyl radical, the nitrile group or an alkoxy-carbonyl group with 1-4 carbon atoms in the alcohol part of furthermore denotes cycloalkyl with 3-6 carbon atoms, or, together with the nitrogen atom which they substitute and, if appropriate, a hetero-atom, such as, for example, oxygen or sulphur, or NR 4 , form a 3-membered to 7-membered ring which can be monosubstituted or polysubstituted by alkyl or alkenyl groups with 1-6 carbon atoms, hydroxyl groups, alkoxy or alkylmercapto groups with 1-3 carbon atoms, an alkoxycarbonyl group with 1-4 carbon atoms in the alcohol part, the nitrile group or a phenyl radical and can furthermore possess a double bond, and R 4 represents hydrogen, or a branched or straightchain alkyl, alkenyl or alkinyl group which has 1-6 carbon atoms and can optionally be substituted by hydroxyl, an alkoxy, alkylmercapto or dialkylamino group with 1-3 carbon atoms per alkyl radical or the alkoxycarbonyl group with 1-4 carbon atoms in the alcohol part, or represents a phenylalkyl group which is optionally substituted in the phenyl radical and has up to 4 carbon atoms in the aliphatic part, or an optionally substituted phenyl or naphthyl group or a heterocyclic radical, such as, for example, a pyridine, pyrimidine, thiazole or benzothiazole nurcleus, or denotes an alkoxycarbonyl group which is optionally substituted by a phenyl radical and has 1 -4 carbon atoms in the alcohol part, an alkanoyl radical with 1-6 carbon atoms, a benzoyl radical, an optionally substituted C1-C6-alkyl or phenylsulphonyl radical or an optionally substituted aminosulphonyl radical, possible substituents of phenyl and naphthyl groups being halogen, alkyl, alkoxy or alkylmercapto groups with 1-3 carbon atoms, phenyloxy, phenylmercapto, trifluoromethyl, nitro, nitrile or carboxylic ester groups with 1-4 carbon atoms in the alcohol part, and pharmaceutically usable salts thereof.