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EP0049593A1
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1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof useful in burn therapy
Assignee: FOX, CHARLES L., JR.
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Filing: 1981-09-29
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Granted: —
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Expires: 2001-09-29
Abstract
Abstract 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof wherein the metal moiety is selected from the group consisting of silver, zinc, cerium and cobalt are useful in the treatment of burns. These compounds may be applied to the affected surface of a burn victim either directly or as part of a composition together with a physiologically acceptable carrier, such as a water-dispersible, hydrophilic carner.
Inventors
- 👤 Charles L. Fox, Jr.
- 👤 Shanta M. Modak
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 07:07
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/54; C07D215/56; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61P; A61P17/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
23 words
A metal salt of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(l-piperazinyl)-3-quinoline carboxylic acid wherein the metal moiety is selected from the group consisting of silver, zinc, cerium, and cobalt.
Claim 2
Dependent Claim
23 words
A metal salt of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(l-piperazinyl)-3-quinoline carboxylic acid wherein the metal moiety is selected from the group consisting of silver, zinc, cerium, and cobalt.
Claim 3
Dependent Claim
14 words
A metal salt in accordance with Claim 1 wherein the metal moiety is silver.
Claim 4
Dependent Claim
20 words
A composition useful for treating burns which comprises an effective amount of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and a physiologically acceptable carrier.
Claim 5
Dependent Claim
20 words
A composition useful for treating burns which comprises an effective amount of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and a physiologically acceptable carrier.
Claim 6
Dependent Claim
25 words
A composition useful for treating burns which comprises an effective amount of a metal salt in accordance with Claim 1 and a physiologically acceptable carrier.
Claim 7
Dependent Claim
23 words
A composition useful for treating burns which comprises an effective amount of the silver salt of Claim 2 and a physiologically acceptable carrier.
Claim 8
Dependent Claim
28 words
For use in treating burns in animal or man by topical application to the affected surface, a composition which comprises an effective antibacterial amount of I-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid.
Claim 9
Dependent Claim
28 words
For use in treating burns in animal or man by topical application to the affected surface, a composition which comprises an effective antibacterial amount of I-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid.
Claim 10
Dependent Claim
12 words
A composition according to Claim 6, further comprising a physiologically acceptable carrier.
Claim 11
Dependent Claim
31 words
For use in treating burns in animal or man by topical application to the affected surface, a composition which comprises an effective antibacterial amount of the metal salt of Claim 1.
Claim 12
Dependent Claim
12 words
A composition according to Claim 8 further comprising a physiologically acceptable carrier.
Claim 13
Dependent Claim
31 words
For use in treating burns in animal or man by topical application to the affected surface, a composition which comprises an effective antibacterial amount of the metal salt of Claim 2.
Claim 14
Dependent Claim
11 words
The composition of Claim 10, further comprising a physiologically acceptable carrier.
Claim 15
Dependent Claim
51 words
Used in treating burns in animal or mn by topical application to the affected surface, a composition which comprises an effective antibacterial amount of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(l-Piperazinyl)-3-quinoline carboxylic acid or a metal salt thereof, the metal moiety of said metal salt being selected from the group consisting of silver, zinc, cerium, and cobalt.
Claim 16
Dependent Claim
51 words
Used in treating burns in animal or mn by topical application to the affected surface, a composition which comprises an effective antibacterial amount of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(l-Piperazinyl)-3-quinoline carboxylic acid or a metal salt thereof, the metal moiety of said metal salt being selected from the group consisting of silver, zinc, cerium, and cobalt.
Claim 17
Dependent Claim
66 words
For use in, or used in treating surface infections such as ulcers, bed sores, surface wounds and the like in animal or man by topical application to the affected surface, a composition which comprises an effective antibacterial amount of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or a metal salt thereof, the metal moiety of said metal salt being selected from the group consisting of silver, zinc, cerium, and cobalt.
Claim 18
Dependent Claim
66 words
For use in, or used in treating surface infections such as ulcers, bed sores, surface wounds and the like in animal or man by topical application to the affected surface, a composition which comprises an effective antibacterial amount of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or a metal salt thereof, the metal moiety of said metal salt being selected from the group consisting of silver, zinc, cerium, and cobalt.
References Cited (Backward Citations)
GB1574285A
Cited
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