1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids, process for their preparation and antibacterial agents containing them

Abstract

Abstract Translated from German 1-Cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsäuren der Formel I <IMAGE> in der R Wasserstoff, Methyl, Ethyl oder β-Hydroxyethyl bedeutet und deren pharmazeutisch verwendbaren Säureadditionssalze und Hydrate weisen eine den bekannten Chinolon- und Azachinolon-carbonsäuren überlegene antibakterielle Wirkung auf. Sie werden hergestellt, in dem man 7-Chlor-1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-chinolin-3-carbonsäure der Formel (R¹ = H) <IMAGE> mit Piperazin oder Piperazinderivaten der Formel <IMAGE> in welcher R die oben angegebene Bedeutung hat, umsetzt. 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids of formula I <IMAGE> in which R is hydrogen, methyl, ethyl or β-hydroxyethyl and their pharmaceutically usable Acid addition salts and hydrates have an antibacterial effect which is superior to that of the known quinolone and azaquinolone carboxylic acids. They are prepared by using 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid of the formula (R¹ = H) <IMAGE> with piperazine or piperazine derivatives of the formula <IMAGE> in which R has the meaning given above.

Inventors

• 👤 Klaus Dr. Grohe
• 👤 Hans-Joachim Dr. Zeiler
• 👤 Karl Georg Dr. Metzger

Bibliographic Details