Patent EP0144534A2 successfully refreshed from Google Patents.
EP0144534A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
prosthetic devices
Assignee: Honeywell International Inc
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Filing: 1984-08-16
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Granted: —
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Expires: 2004-08-16
Abstract
Abstract A sterile shaped prosthetic device, suitable for insertion into a mammalian body, is at least partly composed of a bioresorbable material that is digestible by macrophages, its surface properties favor the attachment and adhesion of fibroblast cells capable of producing collagen for organized connective tissues, and the material itself or its degradation products can induce in vivo the formation of new capillary vessels (termed a "vasotropic" effect herein). Preferred prosthetic devices have through passages, the interspatial dimensions which are sufficient to permit several layers of mammalian cells to form within each passage. The invading fibroblast cells commence formation of collagen leading to connective tissue while macrophages and extracellular enzymes degrade the material, and newly formed capillary vessels penetrate the prosthesis and provide blood containing oxygen and nutrients which further the formation of organized tissue around as well as within the prosthetic device.
Inventors
- 👤 Amery Nyilas
- 👤 Chiu Tin-Ho
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 22:45
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/14; A61L27/18; A61F2210/00; A61F2210/0004
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
38 words
A sterile prosthetic device suitable for insertion into a mammalian body, at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages.
Claim 2
Dependent Claim
38 words
A sterile prosthetic device suitable for insertion into a mammalian body, at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages.
Claim 3
Dependent Claim
32 words
The prosthetic device of claim 1 wherein said prosthetic device has through passages, the interspacial dimensions of which are sufficient to permit several layers of mammalian cells to form within each passage.
Claim 4
Dependent Claim
61 words
The prosthetic device of claim 2 wherein the total surface free energy γ s of said bioresorbable mateial is in the range of 35-60 dynes per centimeter and the dispersion force component, y is predominant. The prosthetic device of claim 3 wherein γ s is in the range of 40-55 dynes per centimeter and y constitutes 60-80 percent of y .
Claim 5
Dependent Claim
25 words
The prosthetic device of claim 1 wherein said bioresorbable material is in the form of a coating of a polyester material that has vasotropic properties.
Claim 6
Dependent Claim
23 words
The prosthetic device of claim 1 wherein said bioresorbable material is a composite of bioresorbable substances that have different in vivo bioresorption rates.
Claim 7
Dependent Claim
23 words
The prosthetic device of claim 1 wherein said bioresorbable material is a polyester derived from a Krebs-Cycle dicarboxylic acid and a metabolizable diol.
Claim 8
Dependent Claim
38 words
The prosthetic device of claim 6 wherein said polyester is formed in a condensation reaction between said Krebs-Cycle dicarboxylic acid and said diol at an elevated temperature with a vacuum-melt polymerization technique in the absence of any catalyst.
Claim 9
Dependent Claim
76 words
A vascular prosthetic device comprising a sterilized flexible, tubular device of fabric scaffold structure, with at least 25 percent of the yarns of said fabric scaffold structure consisting solely of bioresorbable material in an arrangement such that, on implantation of the vascular prosthesis in a mammalian body, the bioresorbable material undergoes absorption and provides passages through the scaffold structure that have interspacial dimensions sufficient to allow several layers of mammalian cells to form within each passage.
Claim 10
Dependent Claim
76 words
A vascular prosthetic device comprising a sterilized flexible, tubular device of fabric scaffold structure, with at least 25 percent of the yarns of said fabric scaffold structure consisting solely of bioresorbable material in an arrangement such that, on implantation of the vascular prosthesis in a mammalian body, the bioresorbable material undergoes absorption and provides passages through the scaffold structure that have interspacial dimensions sufficient to allow several layers of mammalian cells to form within each passage.
Claim 11
Dependent Claim
32 words
The prosthetic device of claim 8 wherein said prosthetic device is a composite structure of nonbioresorbable multifilament yarns in a fabric array with through passages in which bioresorbable multifilament yarns are disposed.
Claim 12
Dependent Claim
23 words
The prosthetic device of claim 8 wherein said bioresorbable material is a polyester derived from a Krebs-Cycle dicarboxylic acid and a metabolizable diol.
Claim 13
Dependent Claim
78 words
ll. A method of forming a prosthetic device, at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages comprising the steps of dipping said device at a controlled rate into a solution of a bioresorbable, vasotropic effect inducing material, and inverting said device and redippig said device in a solution of bioresorbable material to form a bioresorbable coating on said device.
Claim 14
Dependent Claim
78 words
ll. A method of forming a prosthetic device, at least a portion of which is of a bioresorbable material whose surface properties favor fibroblast cell attachment and adhesion, and also encourage the infiltration of macrophages comprising the steps of dipping said device at a controlled rate into a solution of a bioresorbable, vasotropic effect inducing material, and inverting said device and redippig said device in a solution of bioresorbable material to form a bioresorbable coating on said device.
Claim 15
Dependent Claim
16 words
The method of claim 11 wherein said device is a fabric of bioresorbable and nonbioresorbable yarns.
Claim 16
Dependent Claim
50 words
The method of claim 12 and including the further steps of stretching said coated fabric and dipping said stretched fabric in a solution of bioresorbable, vasotropic effect inducing material to form a prosthetic fabric article that has a leak rate of less than about 100 ml cm min -1 .
Claim 17
Dependent Claim
25 words
The method of claim 11 wherein said bioresorbable vasotropic effect inducing material is a polyester derived from a Krebs-Cycle dicarboxylic acid and a metabolizable diol.
Claim 18
Dependent Claim
20 words
The method of claim 14 wherein said polyester is selected from the class consisting of poly(D,L-lactic acid) and poly(2,3-butylene succinate).
References Cited (Backward Citations)
No citation records indexed.
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