Patent EP0170105B1 successfully refreshed from Google Patents.
EP0170105B1
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Benzoic acid derivatives
Assignee: Research Foundation Itsuu Laboratory
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Filing: 1985-07-05
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Granted: 1990-10-17
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Expires: 2005-07-05
Abstract
No abstract record available.
Inventors
- 👤 Koichi Prof. Dr. Shudo
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-31 03:25
CPC Classifications
C; C07; C07D; C07D303/00; C07D303/02; C07D303/38; C07C; C07C233/00; C07C233/64; C07C233/65; C07C65/00; C07C65/32; C07C65/38; C07C65/40; C07D303/40
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
124 words
A benzoic acid derivative represented by the formula (I): wherein R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different, each represents hydrogen, middle alkyl and/or cycloalkyl having 3 to 7 atoms, with the proviso each can not be hydrogen simultaneously, and both neighboring substituents may be combined with each other to form a ring having 5 to 12 carbon atoms, R 6 represents hydroxyl, lower alkoxyl, a group of the formula ―NR 7 'R 8 ', wherein R 7 ' and R 8 ' each represents hydrogen or lower alkyl, X represents a group of the formula: wherein R 7 and R 8 represent hydrogen or lower alkyl with the exception of Hexyl-4[(4-butylphenyl)azoxy]-Benzoate.
Claim 2
Dependent Claim
124 words
A benzoic acid derivative represented by the formula (I): wherein R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different, each represents hydrogen, middle alkyl and/or cycloalkyl having 3 to 7 atoms, with the proviso each can not be hydrogen simultaneously, and both neighboring substituents may be combined with each other to form a ring having 5 to 12 carbon atoms, R 6 represents hydroxyl, lower alkoxyl, a group of the formula ―NR 7 'R 8 ', wherein R 7 ' and R 8 ' each represents hydrogen or lower alkyl, X represents a group of the formula: wherein R 7 and R 8 represent hydrogen or lower alkyl with the exception of Hexyl-4[(4-butylphenyl)azoxy]-Benzoate.
Claim 3
Dependent Claim
2 words
p-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylcarbamoyl)benzoic acid.
Claim 4
Dependent Claim
2 words
p-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylcarbamoyl)benzoic acid.
Claim 5
Dependent Claim
1 words
3',5'-Di-tert-butyl-4-carboxychalcone.
Claim 6
Dependent Claim
1 words
3',5'-Di-tert-butyl-4-carboxychalcone.
Claim 7
Dependent Claim
3 words
p-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalen carboxyamid)benzoic acid.
Claim 8
Dependent Claim
3 words
p-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalen carboxyamid)benzoic acid.
Claim 9
Dependent Claim
2 words
Methyl p-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)azobenzoate.
Claim 10
Dependent Claim
2 words
Methyl p-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)azobenzoate.
Claim 11
Dependent Claim
2 words
1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-4-(methoxycarbonylphenyl)ethylene oxide.
Claim 12
Dependent Claim
2 words
1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-4-(methoxycarbonylphenyl)ethylene oxide.
Claim 13
Dependent Claim
2 words
p-(3,4-diisopropylphenylcarbamoyl)benzoic acid.
Claim 14
Dependent Claim
2 words
p-(3,4-diisopropylphenylcarbamoyl)benzoic acid.
Claim 15
Dependent Claim
23 words
A differentiation-inducing agent for neoplastic cells, especially leukemia cells comprising as active ingredients one or more benzoic acids of claims 1 to 7.
Claim 16
Dependent Claim
47 words
Method for diagnosis to determine the type of leukemia which comprises the incubation of the blood of a patient with leukemia in vitro in the presence of a compound of claims 1 to 7 and the observation of morphological changes and/of colony formation of the leukemia cell.
Claim 17
Dependent Claim
24 words
A substance or composition for the treatment of human or animal leukemia which comprises one or more benzoic acids of claims 1 to 7.
Claim 18
Dependent Claim
70 words
A process for preparation of a benzoic acid derivative represented by the formula (I) of claim 1 wherein R i , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in claim 1 and X represents a group of the formula: by condensation of a corresponding acetophenone derivative with a terephthalaldehyde acid ester or its derivative in the presence of a base.
Claim 19
Dependent Claim
68 words
A process for preparation of a benzoic acid derivative represented by the formula (I) of claim 1 wherein R i , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in claim 1 and X represents a group of the formula: by oxidation of a corresponding compound, wherein X represents a group of the formula: with an agent for epoxidation.
Claim 20
Dependent Claim
69 words
A process for preparation of a benzoic acid derivative represented by the formula (I) of claim 1 wherein R i , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in claim 1 and X represents a group of the formula: by condensation of a corresponding aniline derivative with a p-nitroso-benzoic acid in the presence or absence of an acidic catalyst.
Claim 21
Dependent Claim
67 words
A process for preparation of a benzoic acid derivative represented by the formula (I) of claim 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in claim 1 and X represents a group of the formula: by condensation of a corresponding phenylhydroxylamine with a p-nitroso-benzoic acid or its derivative, as described in claim 13.
Claim 22
Dependent Claim
68 words
A process for preparation of a benzoic acid derivative represented by the formula (I) of claim 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in claim 1 and X represents a group of the formula: by condensation of a nitroso benzene derivative with p-hydroxylamino benzoic acid or its derivative, as described in claim 13.
Claim 23
Dependent Claim
70 words
A process for preparation of a benzoic acid derivative represented by the formula (I) of claim 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in claim 1 and X represents a group of the formula: by acylation of a corresponding aniline derivative with a functional derivative of terephthalic acid (acid halogemide or ester of the acid).
Claim 24
Dependent Claim
85 words
A process for preparation of a benzoic acid derivative represented by the formula (I) of claim 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in claim 1 and'X represents a group of the formula: by acylation of p-amino benzoic acid or its derivative with a functional derivative of a corresponding benzoic acid (acid halogenide or ester thereof) in the usual manner and, if necessary or desirable, the obtained compound is hydrolized.
References Cited (Backward Citations)
DE2854354A1
Cited
EP0064667A1
Cited
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