Patent EP0172458A2 successfully refreshed from Google Patents.
EP0172458A2
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EP
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Novel biologically active compound having anti-prolyl endopeptidase activity
Assignee: Suntory Ltd
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Filing: 1985-07-30
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Granted: —
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Expires: 2005-07-30
Abstract
Abstract A novel compound that exhibits inhibitory activity against prolyl endopeptidase and a method for chemical synthesis of said compound, as well as its use as a prolyl endopeptidase inhibitor and an anti-amnesic agent that contains said compound as the active ingredient are provided.
Inventors
- 👤 Takaharu Tanaka
- 👤 Naoki Higuchi
- 👤 Masayuki Saito
- 👤 Masaki Hashimoto
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-30 16:06
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/08; A; A61; A61P; A61P25/00; A61P25/28; A61P43/00; C07D207/10; C07D207/16
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
28 words
An N-acylpyrrolidine derivative of formula (I): (wherein n is a number of 1 to 4; R is a lower alkyl ester group, -CH 2 0H or aldehyde group).
Claim 2
Dependent Claim
28 words
An N-acylpyrrolidine derivative of formula (I): (wherein n is a number of 1 to 4; R is a lower alkyl ester group, -CH 2 0H or aldehyde group).
Claim 3
Dependent Claim
59 words
A process for producing an N-acylpyrrolidine derivative of formula (II): (wherein n is a number of 1 to 4; R' is a lower alkyl group) by reacting a carboxylic acid, a carboxylic anhydride or a carboxylic acid chloride of the formula: or (wherein n is a number of 1 to 4) with a p roline lower alkyl ester hydrochloride.
Claim 4
Dependent Claim
59 words
A process for producing an N-acylpyrrolidine derivative of formula (II): (wherein n is a number of 1 to 4; R' is a lower alkyl group) by reacting a carboxylic acid, a carboxylic anhydride or a carboxylic acid chloride of the formula: or (wherein n is a number of 1 to 4) with a p roline lower alkyl ester hydrochloride.
Claim 5
Dependent Claim
101 words
A process for producing an N-acylpyrrolidine derivative of formula (IV): (wherein n is a number of 1 to 4) by first reacting a carboxylic acid, a carboxylic anhydride or a carboxylic acid chloride of the formula: or (wherein n is a number of 1 to 4) with a proline lower alkyl ester hydrochloride so as to obtain an N-acylpyrrolidine derivative of formula (II): (wherein n is a number of 1 to 4; R' is a lower alkyl group), reducing said derivative to a compound of formula (III): (wherein n is a number of 1 to 4), and oxidizing said compound (III).
Claim 6
Dependent Claim
101 words
A process for producing an N-acylpyrrolidine derivative of formula (IV): (wherein n is a number of 1 to 4) by first reacting a carboxylic acid, a carboxylic anhydride or a carboxylic acid chloride of the formula: or (wherein n is a number of 1 to 4) with a proline lower alkyl ester hydrochloride so as to obtain an N-acylpyrrolidine derivative of formula (II): (wherein n is a number of 1 to 4; R' is a lower alkyl group), reducing said derivative to a compound of formula (III): (wherein n is a number of 1 to 4), and oxidizing said compound (III).
Claim 7
Dependent Claim
33 words
A prolyl endopeptidase inhibitor comprising an N-acylpyrrolidine derivative of formula (I): (wherein n is a number of 1 to 4; R is a lower alkyl ester group, -CH 2 0H or aldehyde group).
Claim 8
Dependent Claim
33 words
A prolyl endopeptidase inhibitor comprising an N-acylpyrrolidine derivative of formula (I): (wherein n is a number of 1 to 4; R is a lower alkyl ester group, -CH 2 0H or aldehyde group).
Claim 9
Dependent Claim
36 words
An anti-amnesic agent containing as the active ingredient an N-acylpyrrolidine derivative of formula (I): (wherein n is a number of 1 to 4; R is a lower alkyl ester group, -CH 2 OH or aldehyde group).
Claim 10
Dependent Claim
36 words
An anti-amnesic agent containing as the active ingredient an N-acylpyrrolidine derivative of formula (I): (wherein n is a number of 1 to 4; R is a lower alkyl ester group, -CH 2 OH or aldehyde group).
References Cited (Backward Citations)
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