Patent EP0224934A2 successfully refreshed from Google Patents.
EP0224934A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Contrast agent, process for its preparation and its use for ultrasonic imaging
Assignee: Individual
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Filing: 1986-12-05
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Granted: —
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Expires: 2006-12-05
Abstract
Abstract A contrast agent for ultrasonic imaging and a process for its preparation is disclosed. The contrast agent is an aqueous protein solution which is characterized in that it comprises microbubbles having a mean particle size of about 2 to 4 microns. The microbubbles are produced by subjecting the solution to light-frequency ultrasonic energy.
Inventors
- 👤 Steven B. Feinstein
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 22:45
CPC Classifications
G; G01; G01S; G01S15/00; G01S15/88; G01S15/89; G01S15/8906; G01S15/899; A; A61; A61B; A61B8/00; A61B8/48; A61B8/481; A61K; A61K49/00; A61K49/22; A61K49/222; A61K49/223; A61B90/00; A61B90/39; A61B2090/3925
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
21 words
An aqueous protein solution characterised in that it comprises microbubbles having a mean particle size of about 2 to 4 microns.
Claim 2
Dependent Claim
21 words
An aqueous protein solution characterised in that it comprises microbubbles having a mean particle size of about 2 to 4 microns.
Claim 3
Dependent Claim
17 words
An aqueous protein solution according to claim 1, characterised in that the protein is human serum albumin.
Claim 4
Dependent Claim
22 words
An aqueous protein solution according to claim 2, characterised in that the human serum albumin solution has a concentration of about 5%.
Claim 5
Dependent Claim
30 words
A process for preparing an aqeous protein solution according any of claims 1 to 3, characterised in that the microbubbles are produced by subjecting the solution to high-frequency ultrasonic energy.
Claim 6
Dependent Claim
24 words
A process according to claim 4, characterised in that high-frequency ultrasonic energy of about 5000 to 30000 Hz, preferably about 20000 Hz, is applied.
Claim 7
Dependent Claim
26 words
A method according to claim 4 or 5, characterized in that the high-frequency ultrasonic energy is applied until the protein contained in the microbubbles is heat-denatured.
Claim 8
Dependent Claim
20 words
The process according to claim 6, characterised in that the microbubbles are raised to a temperature of 50°C or higher.
Claim 9
Dependent Claim
26 words
A process according to any of claims 4 to 7, characterised in that the microbubbles are further chemically denatured after subjecting them to high-frequency ultrasonic energy.
Claim 10
Dependent Claim
19 words
A process according to claim 8, characterised in that the microbubbles are chemically denatured with formaldehyde or with glutaraldehyde.
Claim 11
Dependent Claim
24 words
The use of an aqueous protein solution according to any of claims 1 to 9 as contrast agent in a method of ultrasonic imaging.
References Cited (Backward Citations)
No citation records indexed.
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