EP0242416A1
Expired / Lapsed
EP
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Method of protein stabilization
Assignee: Valcor Scientific Ltd
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Filing: 1986-04-22
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Granted: —
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Expires: 2006-04-22
Abstract
Abstract Peptides, polypeptides, proteins, proteinaceous hormones, and enzymes are modified by covalently bonding chondroitin thereto, whereby their stability toward in vivo degradation is increased.
Inventors
- 👤 Lorraine F. Meisner
- 👤 Michael R. Schinitsky
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 01:35
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/0004; C12N9/0089; A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/44; A61K38/446; C07; C07K; C07K1/00; C07K1/107; C07K1/1072; C07K1/1077; C07K14/00; C07K14/435; C07K14/575; C07K14/62; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0069
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
39 words
A chemically modified substance of the class of peptides, polypeptides, proteins, proteinaceous hormones, and enzymes, said modified substance having chondroitin covalently bonded thereto, whereby said modified substance has increased stability toward degradation in vivo compared with the unmodified substance.
Claim 2
Dependent Claim
39 words
A chemically modified substance of the class of peptides, polypeptides, proteins, proteinaceous hormones, and enzymes, said modified substance having chondroitin covalently bonded thereto, whereby said modified substance has increased stability toward degradation in vivo compared with the unmodified substance.
Claim 3
Dependent Claim
8 words
A chemically modified peptide as in claim 1.
Claim 4
Dependent Claim
8 words
A chemically modified polypeptide as in claim 1.
Claim 5
Dependent Claim
8 words
A chemically modified protein as in claim 1.
Claim 6
Dependent Claim
9 words
A chemically modified proteinaceous hormone as in claim 1.
Claim 7
Dependent Claim
8 words
A chemically modified insulin as in claim 5.
Claim 8
Dependent Claim
8 words
A chemically modified enzyme as in claim 1.
Claim 9
Dependent Claim
9 words
A chemically modified superoxide dissutase as in claim 7.
Claim 10
Dependent Claim
13 words
A chemically modified substance as in claim 1 wherein said chondroitin is chondroitin-4-sulfate.
Claim 11
Dependent Claim
13 words
A chemically modified substance as in claim 1 wherein said chondroitin is chondroitin-6-sulfate.
Claim 12
Dependent Claim
22 words
A chemically modified substance as in claim 1 wherein said chondroitin has a molecular weight between about 5,000 and about 100,000 daltons.
Claim 13
Independent Claim
26 words
A method for increasing the stability of peptides, polypeptides, proteins, proteinaceous hormones, and enzymes toward degradation in vivo , which comprises covalently bonding a chondroitin thereto.
Claim 14
Independent Claim
26 words
A method for increasing the stability of peptides, polypeptides, proteins, proteinaceous hormones, and enzymes toward degradation in vivo , which comprises covalently bonding a chondroitin thereto.
Claim 15
Dependent Claim
42 words
In a method of administering biologically active peptides to enhance or achieve a desired physiological response known to be elicited by said peptide, the improvement which comprises administering said peptide in combination with chondroitin chemically bonded thereto to prolong the desired response.
Claim 16
Dependent Claim
42 words
In a method of administering biologically active peptides to enhance or achieve a desired physiological response known to be elicited by said peptide, the improvement which comprises administering said peptide in combination with chondroitin chemically bonded thereto to prolong the desired response.
Claim 17
Dependent Claim
11 words
The method of claim 13 wherein said peptide is a protein.
Claim 18
Dependent Claim
12 words
The method of claim 13 wherein said peptide is a proteinaceous hormone.
Claim 19
Dependent Claim
11 words
The method of claim 15 wherein said proteinaceous hormone is insulin.
Claim 20
Dependent Claim
11 words
The method of claim 13 wherein said peptide is an enzyme.
Claim 21
Dependent Claim
11 words
The method of claim 17 wherein said enzyme is superoxide dismutase.
Claim 22
Dependent Claim
10 words
The method of claim 13 wherein said chondroitin is chondroitin-4-sulfate.
Claim 23
Dependent Claim
10 words
The method of claim 13 wherein said chondroitin is chondroitin-6-sulfate.
Claim 24
Dependent Claim
19 words
The method of claim 13 wherein said chondroitin has a molecular weight between about 5,000 and about 100,000 daltons.
Claim 25
Independent Claim
41 words
A method for prolonging the desired physiological response known to be elicited upon administration of a biologically active peptide, which method comprises administering said peptide in a biologically active stabilized form consisting essentially of said peptide havng chondroitin covalently bonded thereto.
Claim 26
Independent Claim
41 words
A method for prolonging the desired physiological response known to be elicited upon administration of a biologically active peptide, which method comprises administering said peptide in a biologically active stabilized form consisting essentially of said peptide havng chondroitin covalently bonded thereto.
References Cited (Backward Citations)
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