Patent EP0249224A2 successfully refreshed from Google Patents.
EP0249224A2
Expired / Lapsed
EP
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Novel antihypertensive agent
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1987-06-11
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Granted: —
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Expires: 2007-06-11
Abstract
Abstract This invention relates to derivatives of fused cyclic azepin-2-ones, to the intermediates and processes useful for their preparation, and to their use as angiotensin converting enzyme inhibitors and to their end-use application as antihypertensive agents.
Inventors
- 👤 Gary A. Flynn
- 👤 Douglas W. Beight
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 16:51
CPC Classifications
C; C07; C07D; C07D223/00; C07D223/14; C07D223/16; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
60 words
A process for preparing a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R is a C 1-6 alkyl and Ph is phenyl, which comprises coupling a fused lactam of the formula with an R-triflate of the formula , with Tf being trifluoromethanesulfonyl, said coupling being effected by contacting said reactants in the presence of a base.
Claim 2
Dependent Claim
60 words
A process for preparing a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R is a C 1-6 alkyl and Ph is phenyl, which comprises coupling a fused lactam of the formula with an R-triflate of the formula , with Tf being trifluoromethanesulfonyl, said coupling being effected by contacting said reactants in the presence of a base.
Claim 3
Dependent Claim
14 words
A process according to claim 1 for preparing a compound wherein R is ethyl.
Claim 4
Dependent Claim
16 words
Use of a compound of claim 1 or 2 for preparing a medicament for treating hypertension.
References Cited (Backward Citations)
No citation records indexed.
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